Core–Shell Gold Nanorod@Metal–Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma

Shang, Wenting; Zeng, Chaoting; Du, Yang; Hui, Hui; Liang, Xiao; Chi, Chongwei; Wang, Kun; Wang, Zhongliang; Tian, Jie

doi:10.1002/adma.201604381

Cited by 182 publications

(129 citation statements)

References 36 publications

Supporting

Mentioning

129

Contrasting

Order By: Relevance

“…Integrating the advantages of CT, MRI, and PAI into one, Tian and co-workers structured a core-shell NMOFs nanoprobe based on PEG-decorated Au nanorods and MIL-88(Fe) for high, enhanced CT, MRI, and PAI imaging of glioma in vivo (Figure 7a). [52] The results showed that the nanoprobe concentrations and the signal intensities of CT, MRI, and PAI exhibited positive linear relationships within a certain range. Notably, Au@MIL-88(Fe) with low cytotoxicity provided high contrast in CT, MRI, and PAI (Figure 7b), which significantly improved imaging sensitivity, high penetration depth, and spatial resolution of glioma imaging in vivo, providing opportunities for advanced multimodal imaging applications of tumors from preclinical to clinical research.…”

Section: Multimodal Bioimagingmentioning

confidence: 91%

“…b) CT (b1,2), MRI (b3,4), and PAI (b5,6) images of U87 MG‐bearing mice before and after intravenous injection with Au@MIL‐88(Fe) nanoplatform. Reproduced with permission 52. Copyright 2016, Wiley‐VCH.…”

Section: Biomedical Applications Of Mofsmentioning

confidence: 94%

“…In addition to CT and MRI, PAI is a novel noninvasive and nonionized biomedical imaging method, which significantly increases imaging depth and spatial resolution. Integrating the advantages of CT, MRI, and PAI into one, Tian and co‐workers structured a core–shell NMOFs nanoprobe based on PEG‐decorated Au nanorods and MIL‐88(Fe) for high, enhanced CT, MRI, and PAI imaging of glioma in vivo ( Figure a) 52. The results showed that the nanoprobe concentrations and the signal intensities of CT, MRI, and PAI exhibited positive linear relationships within a certain range.…”

Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

“…Particularly, the good dispersibility and biocompatibility of NMOFs ensure the biosecurity for in vivo applications. [7] In this review article, we will summarize the recent developments of MOF-based composite materials including the synthesis and functionalization [8][9][10][11][12][13][14][15] and their biomedical applications in the delivery of cargos including drugs, nucleic acids, proteins, and dyes (Table 1), [19,21-23,25-29,31b,d,34-41] bioimaging (Table 2), [43][44][45][47][48][49][50][51][52][53][54] antimicrobial (Table 3), [57,[60][61][62][63][64][65][66][67] biosensing (Table 4), [69][70][71][72][73][75][76][77][78][79][80][81][82][83...…”

Section: Doi: 101002/smll201906846mentioning

confidence: 99%

See 3 more Smart Citations

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

Small

532

356

View full text Add to dashboard Cite

Metal–organic frameworks (MOFs) are an interesting and useful class of coordination polymers, constructed from metal ion/cluster nodes and functional organic ligands through coordination bonds, and have attracted extensive research interest during the past decades. Due to the unique features of diverse compositions, facile synthesis, easy surface functionalization, high surface areas, adjustable porosity, and tunable biocompatibility, MOFs have been widely used in hydrogen/methane storage, catalysis, biological imaging and sensing, drug delivery, desalination, gas separation, magnetic and electronic devices, nonlinear optics, water vapor capture, etc. Notably, with the rapid development of synthetic methods and surface functionalization strategies, smart MOF‐based nanocomposites with advanced bio‐related properties have been designed and fabricated to meet the growing demands of MOF materials for biomedical applications. This work outlines the synthesis and functionalization and the recent advances of MOFs in biomedical fields, including cargo (drugs, nucleic acids, proteins, and dyes) delivery for cancer therapy, bioimaging, antimicrobial, biosensing, and biocatalysis. The prospects and challenges in the field of MOF‐based biomedical materials are also discussed.

show abstract

Section: Multimodal Bioimagingmentioning

confidence: 91%

Section: Biomedical Applications Of Mofsmentioning

confidence: 94%

Section: Biomedical Applications Of Mofsmentioning

confidence: 99%

Section: Doi: 101002/smll201906846mentioning

confidence: 99%

See 2 more Smart Citations

Metal–Organic Frameworks for Biomedical Applications

Yang

2020

Small

532

356

View full text Add to dashboard Cite

show abstract

“…Magnetic resonance imaging (MRI) has the characteristics of safe, noninvasive, high spatial resolution, multi‐azimuth, and multi‐parameter imaging 1,2. At the same time, the obtained anatomical information is not affected by tissue depth 3,4. In clinical diagnosis today, MRI is rated among the very significant imaging modalities 5,6.…”

Section: Introductionmentioning

confidence: 99%

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Wei

Jiang

Pan

et al. 2020

Small

View full text Add to dashboard Cite

The market of available contrast agents for clinical magnetic resonance imaging (MRI) has been dominated by gadolinium (Gd) chelates based T1 contrast agents for decades. However, there are growing concerns about their safety because they are retained in the body and are nephrotoxic, which necessitated a warning by the U.S. Food and Drug Administration against the use of such contrast agents. To ameliorate these problems, it is necessary to improve the MRI efficiency of such contrast agents to allow the administration of much reduced dosages. In this study, a ten‐gram‐scale facile method is developed to synthesize organogadolinium complex nanoparticles (i.e., reductive bovine serum albumin stabilized Gd‐salicylate nanoparticles, GdSalNPs‐rBSA) with high r1 value of 19.51 mm−1 s−1 and very low r2/r1 ratio of 1.21 (B0 = 1.5 T) for high‐contrast T1‐weighted MRI of tumors. The GdSalNPs‐rBSA nanoparticles possess more advantages including low synthesis cost (≈0.54 USD per g), long in vivo circulation time (t1/2 = 6.13 h), almost no Gd3+ release, and excellent biosafety. Moreover, the GdSalNPs‐rBSA nanoparticles demonstrate excellent in vivo MRI contrast enhancement (signal‐to‐noise ratio (ΔSNR) ≈ 220%) for tumor diagnosis.

show abstract

pH‐Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

Liu

Wang

et al. 2017

Adv Funct Materials

View full text Add to dashboard Cite

Although various types of radiosensitizers based on nanoparticles are explored to enhance radiotherapy via different mechanisms, nanoscale radiosensitizers with full biodegradability, sensitive responsiveness to the tumor microenvironment, as well as the ability to greatly amplify radiation‐induced tumor destruction are still demanded. Herein, this study designs nanoscale coordination polymers (NCPs) based on acidic sensitive linker and high Z number element hafnium (Hf) ions. Chloro(triphenylphosphine)gold(I) (TPPGC), a chemotherapeutic drug, is successfully loaded into those NCPs after they are coated with polyethylene glycol (PEG). Owing to the acid‐triggered cleavage of the organic linker, such formed NCP‐PEG/TPPGC nanoparticles would be dissociated under reduced pH within the tumor, leading to the release of TPPGC to induce mitochondrial damage and arrest the cell cycle of tumor cells into the radiosensitive phase (G1). Meanwhile, Hf ions are able to act as radiosensitizers by absorbing X‐ray and depositing radiation energy within tumors. With efficient tumor accumulation after intravenous injection, NCP‐PEG/TPPGC offers remarkable synergistic therapeutic outcome in chemoradiotherapy without appreciable toxic side effect. This work thus presents a biodegradable nano‐radiosensitizer with in vivo tumor‐specific decomposition/drug release profiles and great efficacy in chemoradiotherapy of cancer.

show abstract

Core–Shell Gold Nanorod@Metal–Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma

Cited by 182 publications

References 36 publications

Metal–Organic Frameworks for Biomedical Applications

Metal–Organic Frameworks for Biomedical Applications

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

pH‐Sensitive Dissociable Nanoscale Coordination Polymers with Drug Loading for Synergistically Enhanced Chemoradiotherapy

Contact Info

Product

Resources

About