Core–shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery I: fabrication

Haartman, Eva von; Jiang, Hua; Khomich, А.А.; Zhang, Jixi; Burikov, Sergey; Dolenko, Tatiana A.; Ruokolainen, Janne; Gu, Hongchen; Shenderova, Olga; Власов, И. И.; Rosenholm, Jessica M.

doi:10.1039/c3tb20308e

Cited by 71 publications

(66 citation statements)

References 43 publications

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“…NDs were coated by a SiO 2 shell 20-90 nm thick depending on TEOS/CTAB ratio. The efficient loading of hydrophobic drug molecules on porous silica was demonstrated [152]. Photoluminescent properties originated from NV centers are preserved for SiO 2 -coated NDs.…”

Section: Sio 2 /Ndsmentioning

confidence: 98%

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Nanodiamonds: From Synthesis and Purification to Deposition Techniques, Hybrids Fabrication and Applications

Arnault

2016

Carbon Nanoparticles and Nanostructures

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The present chapter summarizes the recent advances in the production and the purification methods of nanodiamonds. The different strategies for seeding and patterning of surfaces are detailed. First reports of hybrids based on nanodiamonds are included like core shell particles or decoration with carbon dots or metallic atoms. Finally, an overview of applications for composites and nanomedicine is provided.

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Section: Sio 2 /Ndsmentioning

confidence: 98%

“…Indeed, silica combines physical and chemical properties like its inertness with its synthesis versatility. HPHT photoluminescent NDs as well as detonation NDs were recently coated by mesoporous silica in one step [152,153]. During this synthesis, tetraethoxy orthosilicate (TEOS) was used as silica source.…”

Section: Sio 2 /Ndsmentioning

confidence: 99%

Nanodiamonds: From Synthesis and Purification to Deposition Techniques, Hybrids Fabrication and Applications

Arnault

2016

Carbon Nanoparticles and Nanostructures

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“…Finally, core-shell multifunctional nanocomposites have been obtained by incorporating fluorescent NDs cores in silica shells. [81][82][83] ND exhibits a sharp Raman peak approximately at 1330 cm −15 which is generally well distinguished from Raman signals from biological samples. 17 20 31 Therefore, NDs can be detected in biological systems by mapping the intensity of such a characteristic Raman peak on the sample with a spatial resolution that can be as small as 100 nm.…”

Section: Imagingmentioning

confidence: 99%

Biomedical Applications of Nanodiamonds: An Overview

Passeri¹,

Rinaldi²,

Ingallina³

et al. 2015

j nanosci nanotechnol

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Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.

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“…Secondly, it is well-known that the cross-section intensity distribution of the doughnut beam has a dark region at the beam center. Nanodiamonds can be coated with a silica shell [24,33], forming a core-shell structure. When the dark region of the beam coincides with the diamond core, the heat absorption will be significantly suppressed.…”

mentioning

confidence: 99%

Optical levitation of nanodiamonds by doughnut beams in vacuum

Zhou

Xiao

Chen

et al. 2017

Laser & Photonics Reviews

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Optically levitated nanodiamonds with nitrogen-vacancy centers promise a high-quality hybrid spinoptomechanical system. However, the trapped nanodiamond absorbs energy form laser beams and causes thermal damage in vacuum. It is proposed here to solve the problem by trapping a composite particle (a nanodiamond core coated with a less absorptive silica shell) at the center of strongly focused doughnut-shaped laser beams. Systematical study on the trapping stability, heat absorption, and oscillation frequency concludes that the azimuthally polarized Gaussian beam and the linearly polarized Laguerre-Gaussian beam LG 03 are the optimal choices. With our proposal, particles with strong absorption coefficients can be trapped without obvious heating and, thus, the spin-optomechanical system based on levitated nanodiamonds are made possible in high vacuum with the present experimental techniques.Introduction-. By trapping, detecting and manipulating nano-and micro-particles [1], optical tweezers are widely used in biophysics [2-4], colloidal sciences [5], chemistry, microfluidic dynamics [6], and fundamental physics [7][8][9][10][11][12][13][14][15]. Because of the wide applicability and high tunablity of the optically levitated systems, several schemes [16] were proposed to realize the ground-state cooling [17], to search for non-Newtonian gravity [18] and to detect gravitational wave [19]. Particularly, it brings about more interesting phenomena and novel applications [20,21] when the trapped particles have internal degrees of freedom (such as spins or electric dipoles) and enter the quantum regime.Optically levitated nanodiamonds with nitrogen-vacancy (NV) centers [22][23][24][25][26] are one of the most promising candidates for implementing a spin-optomechanical hybrid system. In principle, this system can have both long spin coherence time and high quality factor of mechanical oscillation in vacuum. The electron spins of NV centers were shown to have long spin coherence time (in the order of 10 2 µs) even in nanodiamonds of diameter about 20 nm [27]. When trapped in high-vacuum, the dielectric particles are predicted to have ultra-high quality factor Q larger than 10 10 [16,18,28]. Researchers have trapped diamond particles and observed the signal from NV centers in liquid [29,30], in air [31] and very recently in vacuum with pressure down to ∼ kPa [24,25] and ∼ 100 Pa [26].Realizing high quality mechanical oscillation requires trapping the particles in high vacuum (e.g, 10 −6 Pa) to get Q ∼ 10 10 . However, the high-vacuum condition usually causes the thermal damage problem, and experimentally trapping a nanodiamond in high vacuum is still very challenging. Nanodiamonds will absorb energy from the trapping laser beams due to the intrinsic defects [26] and the inevitable imperfections or graphitization [32] on diamond surface. The absorbed energy can hardly be dissipated in a high-vacuum environment, and the nanodiamonds will be quickly heated up significantly [24][25][26], which is unfavorable to the defect centers...

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Core–shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery I: fabrication

Cited by 71 publications

References 43 publications

Nanodiamonds: From Synthesis and Purification to Deposition Techniques, Hybrids Fabrication and Applications

Nanodiamonds: From Synthesis and Purification to Deposition Techniques, Hybrids Fabrication and Applications

Biomedical Applications of Nanodiamonds: An Overview

Optical levitation of nanodiamonds by doughnut beams in vacuum

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