Core–shell composite particles composed of biodegradable polymer particles and magnetic iron oxide nanoparticles for targeted drug delivery

Oka, Chiemi; Ushimaru, Kazunori; Horiishi, Nanao; Tsuge, Takeharu; Kitamoto, Yoshitaka

doi:10.1016/j.jmmm.2015.01.005

Cited by 51 publications

(16 citation statements)

References 31 publications

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“…When individual unique properties of both MNP and polymer matrix were combined, multifunctional nanocomposite serving as a platform for further conjugation with desirable bioentities can be obtained [16,17]. Thus, this hybrid nanocomposite has been particularly used in the biological field such as drug delivery system [18,19], controlled release [16,20,21], and magnetic separation [11][12][13]. Previous works have reported the synthesis of MNP-polymer nanocomposite having both good magnetic separation ability and good water dispersibility for drug controlled release [4,16] and for conjugation with bioentities [17,22].…”

Section: Introductionmentioning

confidence: 99%

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

Deepuppha

Khadsai

Rutnakornpituk

et al. 2019

Journal of Nanomaterials

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pH- and thermoresponsive nanocomposite composed of poly(N-acryloyl glycine) (PNAG) matrix and magnetite nanoparticle (MNP) was synthesized and then used for drug controlled release application. The effects of crosslinkers, e.g., ethylenediamine and tris(2-aminoethyl)amine, and their concentrations (1 and 10 mol%) on the size, magnetic separation ability, and water dispersibility of the nanocomposite were investigated. The nanocomposite crosslinked with tris(2-aminoethyl)amine (size ranging between 50 and 150 nm in diameter) can be rapidly separated by a magnet while maintaining its good dispersibility in water. It can respond to the pH and temperature change as indicated by the changes in its zeta potential and hydrodynamic size. From the in vitro release study, theophylline as a model drug was rapidly released when the pH changed from neutral to acidic/basic conditions or when increasing the temperature from 10°C to 37°C. This novel nanocomposite showed a potential application as a magnetically guidable vehicle for drug controlled release with pH- and thermotriggered mechanism.

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Section: Introductionmentioning

confidence: 99%

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

Deepuppha

Khadsai

Rutnakornpituk

et al. 2019

Journal of Nanomaterials

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“…11,12 Novel drug delivery systems such as nanoparticles, micelles, and liposomes can be used to enhance drug stability and efficacy while reducing the side effect of Bis. [13][14][15] There has been a flood of novel nanoparticle therapies researched in recent years. In 1981, Massart successfully synthesized magnetic iron (II, III) oxide nanoparticles by employing an aqueous chemical co-precipitation method, and in the past decade, there has been widespread synthesis of magnetic nanoparticles conjugated with a variety of drugs.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of composite magnetic nanoparticles Fe<sub>3</sub>O<sub>4</sub> with alendronate for osteoporosis treatment

Lee¹,

Su²,

Yeh³

et al. 2016

IJN

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Osteoporosis is a result of imbalance between bone formation by osteoblasts and resorption by osteoclasts (OCs). In the present study, we investigated the potential of limiting the aggravation of osteoporosis by reducing the activity of OCs through thermolysis. The proposed method is to synthesize bisphosphonate (Bis)-conjugated iron (II, III) oxide (Fe 3 O 4 ) nanoparticles and incorporate them into OCs. The cells should be subsequently exposed to radiofrequency (RF) to induce thermolysis. In this study, particles of Fe 3 O 4 were first synthesized by chemical co-precipitation and then coated with dextran (Dex). The Dex/Fe 3 O 4 particles were then conjugated with Bis to form Bis/Dex/Fe 3 O 4 . Transmission electron microscopy revealed that the average diameter of the Bis/Dex/Fe 3 O 4 particles was ~20 nm. All three kinds of nanoparticles were found to have cubic inverse spinel structure of Fe 3 O 4 by the X-ray diffraction analysis. Fourier transform infrared spectroscopy confirmed that the Dex/Fe 3 O 4 and Bis/Dex/Fe 3 O 4 nanoparticles possessed their respective Dex and Bis functional groups, while a superconducting quantum interference device magnetometer measured the magnetic moment to be 24.5 emu. In addition, the Bis/Dex/Fe 3 O 4 nanoparticles were fully dispersed in double-distilled water. Osteoblasts and OCs were individually cultured with the nanoparticles, and an MTT assay revealed that they were non-cytotoxic. An RF system (42 kHz and 450 A) was used to raise the temperature of the nanoparticles for 20 minutes, and the thermal effect was found to be sufficient to destroy OCs. Furthermore, in vivo studies verified that nanoparticles were indeed magnetic resonance imaging contrast agents and that they accumulated after being injected into the body of rats. In conclusion, we developed a water-dispersible magnetic nanoparticle that had RF-induced thermogenic properties, and the results indicated that the Bis/Dex/Fe 3 O 4 nanoparticle had the potential for controlling osteoporosis.

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“…For instance, Kikuo Okuyama and coworkers [19] have reported completely spherical dense particles, small rough spherical dense particles, highly rough spherical dense particles, hollow particles, doughnut particles, porous particles, encapsulated particles, mixed particles and hairy particles. Oka Chiemi and coworkers have reported the synthesis of core-shell composite particles [10], and other morphologies such as nanowires, nanorods, nanoworms, nanotubes and so on have been reported in the literature. We have obtained meso-macroporous BaO.6Fe 2 O 3 nanostructured aggregates with a spherical shape.…”

Section: Resultsmentioning

confidence: 99%

“…Recent years a surge has been seen in magnetic nanoparticles applications in several areas such as microelectronics, optoelectronics, physics, chemistry, biology, and materials science, but particularly in biomedical field [1][2][3][4][5][6][7][8][9][10]. Several sorts of magnetic nanoparticles have been widely investigated for biomedical applications, among which iron oxide-based magnetic nanoparticles are very promising candidates due to their unique features like biocompatibility, large surface area and superparamagnetic behavior that make them an ideal tool for cell separation, magnetic resonance imaging (MRI) [11][12], cancer treatment by hyperthermia [13][14][15] drug delivery systems (DDS) [16,17].…”

Section: Introductionmentioning

confidence: 99%

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

Torres-Cadenas¹,

Bravo-Patino²,

Zárate‐Medina³

et al. 2017

Epitoanyag - JSBCM

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recent years a surge has been seen in magnetic nanoparticles applications in several areas, particularly in biomedical field. the promising features of the iron oxide based magnetic nanoparticles make them an ideal tool for mri contrast agents, hyperthermia, and as drug delivery systems (DDs). the present paper describes the design and synthesis of Bao·6Fe 2 o 3 nanostructured meso-macroporous spherical aggregates by sol-gel method via spray drying technique. the obtained spherical aggregates have micrometric size, which let them to be carried by the bloodstream to a specific site where the drug is going to be release. the obtained hierarchical porous structure combined with the interconnected mesoporosity allow the body fluids to be transport through the aggregates; and the macroporosity allows the load of large molecules, like peptides. Furthermore, the structural and morphological characterization of the obtained Bao·6Fe 2 o 3 aggregates were carried out using X-ray diffraction and field emission scanning electron microscopy. keywords: nest-like morphology, hierarchical porous structure, drug delivery, barium hexaferrite.

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Core–shell composite particles composed of biodegradable polymer particles and magnetic iron oxide nanoparticles for targeted drug delivery

Cited by 51 publications

References 31 publications

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

Synthesis of composite magnetic nanoparticles Fe<sub>3</sub>O<sub>4</sub> with alendronate for osteoporosis treatment

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

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Core–shell composite particles composed of biodegradable polymer particles and magnetic iron oxide nanoparticles for targeted drug delivery

Cited by 51 publications

References 31 publications

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

Multiresponsive Poly(N-Acryloyl glycine)-Based Nanocomposite and Its Drug Release Characteristics

Synthesis of composite magnetic nanoparticles&nbsp;Fe<sub>3</sub>O<sub>4</sub>&nbsp;with alendronate for osteoporosis treatment

2017/1 issue read download 2017/1 – Content Nest-like BaO•6Fe2O3 microspheres with hierarchical porous structure for drug delivery

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Synthesis of composite magnetic nanoparticles Fe<sub>3</sub>O<sub>4</sub> with alendronate for osteoporosis treatment