Core–Shell Chitosan Microcapsules for Programmed Sequential Drug Release

Yang, Xiulan; Ju, Xin; Mu, Xiao-Ting; Wang, Wei; Xie, Rui; Liu, Zhuang; Chu, Liang‐Yin

doi:10.1021/acsami.6b01277

Cited by 134 publications

(99 citation statements)

References 38 publications

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“…Some studies have reported the potential to use multiple polymer types as highlighted by Yang et al [67] They designed a release system made of cross-linked chitosan containing both free drug molecules and drug-loaded PLGA nanoparticles. Before exposure to acid or pH stimulus, the chitosan can keep their structural integrity without leakage of the encapsulated substances.…”

Section: Design and Structure Of Smart Radiotherapy Biomaterialsmentioning

confidence: 99%

Smart Radiation Therapy Biomaterials

Ngwa

Boateng

Kumar

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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Radiotherapy is a crucial component of cancer care, employed in the treatment of over 50% of cancer patients. Patients undergoing image-guided radiotherapy or brachytherapy routinely have inert radiotherapy (RT) biomaterials implanted into their tumors. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Recent studies have proposed that the inert biomaterials could be upgraded to ‘smart’ RT biomaterials, designed to do more than one function. Such smart biomaterials include next generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimulus and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor sub-volume, while minimizing normal tissue toxicities. More broadly, smart RT biomaterials may include functionalized nanoparticles that can be activated to boost radiotherapy efficacy. This work reviews the rationale for smart radiotherapy biomaterials, the state-of-the-art in this emerging cross-disciplinary research area, challenges/opportunities for further research and development, and a purview of potential clinical applications. Applications covered include using smart RT biomaterials for boosting cancer therapy with minimal side effects, combining radiotherapy with immunotherapy or chemotherapy, reducing treatment time or healthcare costs, and other incipient applications.

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Section: Design and Structure Of Smart Radiotherapy Biomaterialsmentioning

confidence: 99%

Smart Radiation Therapy Biomaterials

Ngwa

Boateng

Kumar

et al. 2017

International Journal of Radiation Oncology*Biology*Physics

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“…For example, chitosan can react with terephthalaldehyde, forming a cross-linked chitosan hydrogel to make core-shell wall of the microcapsules applied in drug delivery system. The microcapsule is composed of a cross-linked chitosan hydrogel shell and an oily core containing drug molecules [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Enhanced Antibacterial Activity of Silver Doped Titanium Dioxide-Chitosan Composites under Visible Light

Xie

Xia

et al. 2018

Materials

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Nano titanium dioxide (TiO2) with photocatalytic activity was firstly modified by diethanolamine, and it was then doped with broad spectrum antibacterial silver (Ag) by in situ method. Further, both Ag doped TiO2-chitosan (STC) and TiO2-chitosan (TC) composites were prepared by the inverse emulsion cross-linking reaction. The antibacterial activities of STC composites were studied and their antibacterial mechanisms under visible light were investigated. The results show that in situ doping and inverse emulsion method led to good dispersion of Ag and TiO2 nanoparticles on the cross-linked chitosan microsphere. The STC with regular particle size of 1–10 μm exhibited excellent antibacterial activity against E. coli, P. aeruginosa and S. aureus under visible light. It is believed that STC with particle size of 1–10 μm has large specific surface area to contact with bacterial cell wall. The increased antibacterial activity was attributed to the enhancement of both electron-hole separations at the surface of nano-TiO2 by the silver ions under the visible light, and the synergetic and sustained release of strong oxidizing hydroxyl radicals of nano-TiO2, together with silver ions against bacteria. Thus, STC composites have great potential applications as antibacterial agents in the water treatment field.

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“…Such a release scheme has shown greatly enhanced anticancer efficacy compared with conventional surgical treatments, radiation therapies, and chemotherapies, and demonstrated enhanced oral bioavailability . pH‐responsive autonomous drug release can be classified into three categories: 1) the use of polymers (polyacids or polybases) with ionizable groups that undergo conformational and/or solubility changes toward environmental pH variation; 2) the design of polymeric systems with acid‐sensitive linkers whose cleavage enables the release of molecules anchored at the polymer or with the ability of modifying the charge in the polymer according to the change in environmental pH; 3) the degradation of the spacers that conjugate the drug to the polymer . Figure provides the molecular formula of representative pH‐sensitive anionic polymers, cationic polymers, acid‐sensitive cleavable linkers, and biodegradable polymers that can be used for designing pH‐responsive ADRS.…”

Section: Autonomous Drug Release Based On Symptom‐associated Signalsmentioning

confidence: 99%

“…Programmed sequential release behaviors of e) curcumin‐loaded and f) catechin‐loaded composite core‐shell microcapsules. d–f) Reproduced with permission . Copyright 2016, American Chemical Society.…”

Section: Autonomous Drug Release Based On Symptom‐associated Signalsmentioning

confidence: 99%

Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers

Xiong

Niu

et al. 2020

Advanced Intelligent Systems

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Many biophysical and biochemical properties of pathogenic tissues are different from those of healthy tissues. These disease symptom‐associated properties include pH, reduction–oxidation conditions, enzyme generation and expression, blood glucose concentration, mechanical stiffness and strain, and temperature. Autonomous drug release that uses one or more of these disease symptom‐associated properties as the release trigger minimizes the delay in treatments and allows for the release of medications with precisely controlled amounts and with desired spatiotemporal patterns. Herein, a comprehensive assessment of current research progress on autonomous drug release systems (ADRS) is provided. The representative symptoms‐associated properties that can be potentially used as the endogenous stimuli are introduced. The autonomous drug systems that utilize these symptom‐associated signals as the endogenous stimulation signals are discussed, followed by the discussion of current challenges and opportunities in this field, as well as possible future directions in ADRS.

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Core–Shell Chitosan Microcapsules for Programmed Sequential Drug Release

Cited by 134 publications

References 38 publications

Smart Radiation Therapy Biomaterials

Smart Radiation Therapy Biomaterials

Enhanced Antibacterial Activity of Silver Doped Titanium Dioxide-Chitosan Composites under Visible Light

Autonomous Drug Release Systems with Disease Symptom‐Associated Triggers

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