Core–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation

Yi, Xuan; Chen, Lei; Zhong, Xiaoyan; Gao, Roulin; Qian, Yiyu; Wu, Fan; Song, Guosheng; Chai, Zhifang; Liu, Zhuang; Yang, Kai

doi:10.1007/s12274-016-1205-8

Cited by 163 publications

(105 citation statements)

References 41 publications

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“…For example, Yi et al developed core–shell Au@MnO 2 NPs for enhanced RT by means of improving the tumor oxygenation ( Figure a) . In this research, Au core and MnO 2 shell served as radiosensitizers to absorb ionizing radiation to enhance RT and oxygen donators to react with H 2 O 2 to generate a mass of O 2 , respectively.…”

Section: Therapeutic Applicationsmentioning

confidence: 93%

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Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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Despite the comprehensive applications in bioimaging, biosensing, drug/gene delivery, and tumor therapy of manganese oxide nanomaterials (MONs including MnO2, MnO, Mn2O3, Mn3O4, and MnOx) and their derivatives, a review article focusing on MON‐based nanoplatforms has not been reported yet. Herein, the representative progresses of MONs on synthesis, heterogene, properties, surface modification, toxicity, imaging, biodetection, and therapy are mainly introduced. First, five kinds of primary synthetic methods of MONs are presented, including thermal decomposition method, exfoliation strategy, permanganates reduction method, adsorption–oxidation method, and hydro/solvothermal. Second, the preparations of hollow MONs and MON‐based composite materials are summarized specially. Then, the chemical properties, surface modification, and toxicity of MONs are discussed. Next, the diagnostic applications including imaging and sensing are outlined. Finally, some representative rational designs of MONs in photodynamic therapy, photothermal therapy, chemodynamic therapy, sonodynamic therapy, radiotherapy, magnetic hyperthermia, chemotherapy, gene therapy, starvation therapy, ferroptosis, immunotherapy, and various combination therapy are highlighted.

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Section: Therapeutic Applicationsmentioning

confidence: 93%

Section: Therapeutic Applicationsmentioning

confidence: 99%

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

et al. 2020

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“…Thus, our group further developed nano-droplets of PFC stabilized by albumin as an oxygen shuttle for tumor-specific delivery of oxygen with the help of tumor-focused low-intensity ultrasound (Figure 13). 2017, 29,1700996 Hemoglobin-based oxygen carrier [230,237] Perfluorocarbon (PFC) emulsions; BSA coated PFC emulsion; PFC loaded hollow Bi 2 Se 3 ; TaOx decorated with PFC nanodroplets [238][239][240][241] Mild hyperthermia [39,71,73] Increase tumor oxygenation by catalysis of endogenic H 2 O 2 MnO 2 nanopartilces; MnO 2 nanosheets@ upconversion; Au@MnO 2 core-shell [242][243][244][245][246][247] Polymer micelles encapsulating catalase and TaOx@catalase [248][249][250] Hypoxia-specific therapy accompany hypoxia-specific cytotoxicity of tirapazamine [58,251] X-ray controlled NO releasing [56] Radioprotection to reduce side effects Free radical scavengers CeO 2 nanoparticles [252,253] Melanin nanoparticles [254,255] MoS 2 dots [256] Oxygen-loaded nanoparticles were able to enhance tumor oxygenation triggered by the NIR laser. injected into tumorbearing mice under hyperoxic breathing.…”

Section: Increase Of Tumor Oxygenation By Oxygen Deliverymentioning

confidence: 99%

“…[246] The Wu group reported that albumin stabilized MnO 2 nanoparticles within H 2 O 2 rich and acidic tumor microenvironment were able to increase tumor oxygenation by triggering decomposition of tumor endogenous H 2 O 2 , and simultaneously increase the tumor pH from pH 6.7 to pH 7.2 in a murine breast tumor model. [242][243][244]247] Based on the endogenous H 2 O 2 inside the hypoxic tumor, our group further developed a novel type of bio-nanoreactors by encapsulating catalase within tantalum oxide nanoshells modified with PEG (Figure 15). Taking advantages of the sensitive pH-/H 2 O 2 -responsive behaviors of MnO 2 , recently MnO 2 nanosheets anchored with upconversion nanoparticels, Au@MnO 2 core-shell nanoparticles, chlorine e6 (Ce6) loaded MnO 2 nanoparticles, and HSA-coated MnO 2 /Ce6/ cisplatin nanoclusters have been developed to overcome tumor hypoxia by converting tumor endogenous H 2 O 2 to H 2 O and O 2 inside the hypoxia tumor microenvironment, for enhanced radiotherapy, photodynamical therapy, or synergetic combination therapy.…”

Section: Increase Of Tumor Oxygenation By Decomposing Tumor Endogenicmentioning

confidence: 99%

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

et al. 2017

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Radiation therapy (RT) including external beam radiotherapy (EBRT) and internal radioisotope therapy (RIT) has been widely used for clinical cancer treatment. However, owing to the low radiation absorption of tumors, high doses of ionizing radiations are often needed during RT, leading to severe damages to normal tissues adjacent to tumors. Meanwhile, the RT efficacies are limited by different mechanisms, among which the tumor hypoxia-associated radiation resistance is a well-known one, as there exists hypoxia inside most solid tumors while oxygen is essential to enhance radiation-induced DNA damages. With the development in nanotechnology, there have been great interests in using nanomedicine strategies to enhance radiation responses of tumors. Nanomaterials containing high-Z elements to absorb radiation rays (e.g. X-ray) can act as radio-sensitizers to deposit radiation energy within tumors and promote treatment efficacy. Nanoscale carriers are able to deliver therapeutic radioisotopes into tumors for internal RIT, or chemotherapeutic drugs for synergistically combined chemo-radiotherapy. As uncovered in recent studies, the tumor microenvironment could be modulated by various nanomedicine approaches to overcome hypoxia-associated radiation resistance. Herein, the authors will summarize the applications of nanomedicine for RT cancer treatment, and pay particular attention to the latest development of 'advanced materials' for enhanced cancer RT.

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“…In recent years, several strategies have been developed to overcome tumor‐hypoxia microenvironment . In our recent work, we designed gold@manganese dioxide core–shell nanoparticles for enhanced RT through the reaction of MnO 2 and H 2 O 2 in tumor microenvironment to generate oxygen and overcome hypoxia‐associated RT resistance . In addition to internal stimuli for oxygenation, external physical stimuli such as mild photothermal therapy (PTT) could boost blood stream into the tumor sites and increase the uptake of oxygen to overcome hypoxia‐associated RT resistance .…”

Section: Introductionmentioning

confidence: 99%

Synergistic Effect of Thermo-Radiotherapy Using Au@FeS Core-Shell Nanoparticles as Multifunctional Therapeutic Nanoagents

Chen

et al. 2017

Part. Part. Syst. Charact.

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Imaging guided combined therapy has attracted great attention in recent years. This study develops core–shell Au@FeS nanoparticles with polyethylene glycol (PEG) coating as multifunctional nanotheranostic agent for tumor imaging and combined photothermal therapy (PTT) and radiotherapy (RT). In this Au@FeS nanostructure, the gold core can act as a radiosensitizer for enhanced RT, while FeS shell offers contrast for T2‐weighted magnetic resonance imaging and endows the nanoparticles with strong high near‐infrared (NIR) for photoacoustic imaging and PTT. As demonstrated by both in vitro and in vivo experiments, Au@FeS‐PEG can act as excellent therapeutic agent for cancer synergistic treatment. More importantly, mild PTT boosts the blood flow into tumor and increases oxygenation to overcome the tumor hypoxia microenvironment, further enhancing the efficacy of RT. Moreover, Au@FeS‐PEG induces on obvious toxicity at a high dose (20 mg kg−1) to the treated mice as evidenced by blood biochemistry. Therefore, this study brings an excellent strategy for cancer enhanced RT through NIR‐triggered mild PTT to overcome hypoxia‐associated radioresistance.

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Core–shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation

Cited by 163 publications

References 41 publications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications

Emerging Nanotechnology and Advanced Materials for Cancer Radiation Therapy

Synergistic Effect of Thermo-Radiotherapy Using Au@FeS Core-Shell Nanoparticles as Multifunctional Therapeutic Nanoagents

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