Core–Satellite Micelles by a Linear A1B1A2B2 Tetrablock Copolymer

Ahn, Seonghyeon; Yoon, Hyeongkeon; Duan, Chao; Li, Weihua; Kim, Jin Kon

doi:10.1021/acs.macromol.1c02075

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…Tetrablock and pentablock copolymer manufacturing has been reported, and starblock copolymers are also being researched [ 36 , 37 , 38 ]. In the latter, blocks are joined to a branching point with more than two polymers rather than being placed in a linear manner ( Figure 2 (II)) [ 38 ].…”

Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Section: General Issues and Status Quo Of Polymeric Micellesmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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“…Indeed, the chain architecture plays an irreplaceable role in controlling the self-assembly behavior of block copolymers. ,− In the past few decades, block copolymers with different architectures have been extensively studied by experiment and theory. Novel structures were experimentally obtained from the self-assembly of architecture-engineered block copolymers. − Accordingly, these experimental results promoted theoretical studies to explore the self-assembly mechanism of these new block copolymers. − In particular, recent theoretical works have been devoted to achieving nonclassical ordered structures by purposely designing the architectures of block copolymers, ,− and great progress has been made. For example, the spherical phase region has been largely expanded by tailoring the asymmetric architectures of AB-type block copolymers, stabilizing complex Frank–Kasper spherical phases. ,− The synergistic effect of the released packing frustration and stretched bridging block has been applied to stabilize many nonclassical low-coordinated phases, such as simple cubic spheres and square cylinders .…”

Section: Introductionmentioning

confidence: 99%

Hierarchical Self-Assembly of ABC-Type Bottlebrush Copolymers

et al. 2023

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We have performed dissipative particle dynamics simulations to study the self-assembly of ABC-type bottlebrush copolymers (BBCPs), one portion of whose backbone is grafted by pairs of A-blocks and the other portion is grafted by B/C-blocks in pairs, focusing on the effects of the number of A side chains, the length of B side chains relative to that of C side chains, and the rigidity of the backbone on the formation of hierarchical structures. A number of hierarchical structures with the superstructures formed by the phase separation between A and B/C-blocks and the substructures formed by the phase separation between B and Cblocks are observed. Some hierarchical structures are similar to those self-assembled by ABC star copolymers, whereas their stable parameter regions of ABC-type BBCPs are much larger. On the other hand, the ABC-type BBCPs can also form some novel hierarchical structures that are hard to form in ABC star copolymers. Though the formation of the A-superstructure and the B-substructure in many hierarchical structures can be independently controlled, there are also some hierarchical structures in which the transitions of the superstructure and substructures are coupled. In other words, the A-superstructure changes along with the transformation of the B-substructure for fixed f A . In addition, our results demonstrate that the rigidity of the backbone has a significant effect on the formation of the hierarchical structure in ABC-type BBCPs, i.e., a rigid backbone favors the normal arrangement of B-substructures to A-superstructures. Our work not only deepens the understanding of the self-assembly mechanism of ABC-type BBCPs but also provides helpful guidance for experiments to fabricate interesting hierarchical structures.

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“…[22][23][24][25][26][27][28] In particular, advanced modern synthesis techniques have facilitated the precise synthesis of more and more block copolymers with various complex architectures and compositions. [29][30][31][32][33][34] More importantly, a series of guiding principles have been established, enabling the rational design of the architectures of block copolymers for new desired selfassembly structures, including conformational or architectural asymmetry, stretched bridging block and released packing frustration. [35][36][37][38][39][40][41][42][43] The conformational and architectural asymmetries, [36] respectively originating from asymmetric segment properties (e. g., segment length b and density 1) of the repeating units in different blocks and the topology of the copolymer, can deflect the phase boundaries and can even stabilize novel spherical phases.…”

Section: Introductionmentioning

confidence: 99%

“…For block copolymers, a critical factor in controlling their self‐assembly behavior is their diverse architectures [22–28] . In particular, advanced modern synthesis techniques have facilitated the precise synthesis of more and more block copolymers with various complex architectures and compositions [29–34] . More importantly, a series of guiding principles have been established, enabling the rational design of the architectures of block copolymers for new desired self‐assembly structures, including conformational or architectural asymmetry, stretched bridging block and released packing frustration [35–43] .…”

Section: Introductionmentioning

confidence: 99%

Reexamining the Emergence and Stability of the Square Cylinder Phase in Block Copolymers

Yuan

et al. 2023

Chemistry A European J

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Recently, a few AB-type multiblock copolymers have been successfully designed to form stable square cylinder phase based on self-consistent field theory (SCFT) calculations. The previous works only identify the stability region of the square phase but not analyzing its stability, which is closely related to the free-energy landscape. In this work, we have reexamined the stability of the square phase in B 1 A 1 B 2 A 2 B 3 linear pentablock and ðB 1 AB 2 Þ 5 star triblock copolymers by drawing the free-energy landscape with respect to the two dimensions of a rectangular unit cell. Our results demonstrate that the square phase continuously transfers to the rectangular phase as the degree of packing frustration is gradually released. Moreover, the prolate contour lines of the free-energy landscape indicate the weak stability of the square phase in the B 1 A 1 B 2 A 2 B 3 copolymer. In contrast, the stability of the square phase is notably improved in the ðB 1 AB 2 Þ 5 copolymer due to its enhanced concentration of bridging configurations. Our work sheds light on the understanding of the stability of the square cylinder phase in block copolymers. Accordingly, we propose some possible strategies for further designing new AB-type block copolymer systems to obtain more stable square phase.

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Core–Satellite Micelles by a Linear A₁B₁A₂B₂ Tetrablock Copolymer

Cited by 3 publications

References 35 publications

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Hierarchical Self-Assembly of ABC-Type Bottlebrush Copolymers

Reexamining the Emergence and Stability of the Square Cylinder Phase in Block Copolymers

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