“…[2] Indolizine skeleton also founds in mammals. [3] It possess plethora of biological and therapeutic applications like anti-fungal, [4] anti-inflammatory, [5] antioxidant, [6] anti-cancer, [7] anti-HIV, [8] anti-viral, [9] antibacterial [10] in addition to this it is also used as fluorescence. [11] Among the indolizine scaffolds, mainly 3-alkyl and 3-aryle Indolizine (Figure 1) shows significant biological activities, which are used as 5-hydroxytryptamine (5-HT3) receptor [12] antagonist, 15-lipoxygenase, [13] phosphoinositide 3-kinase, [14] phosphodiesterase-4 (PDE-4), [15] tumor necrosis factor (TNF-α) inhibitors [16] as orexin receptor, [17] human group (IIa) secreted phospholipase A2 (sPLA2), [18] sodium-glucose cotransporter-2 (SGLT2).…”