Fiber sensors based on Mach-Zehnder interference have attracted considerable attention over the past few decades. All kinds of fibers, including standard single mode fiber (SMFs), multimode fiber (MMFs), photonic crystal fibers (PCFs) and other special fibers, have been explored to fabricate fiber-based Mach-Zehnder interferometers (MZIs) for various applications. Recently, a new type of PCF, so-called simplified hollow core photonic crystal fiber (HCPCF), is proposed by Frdric Grme et.al in Ref. [l]. In Ref.[2], another simplified HCPCF with a similar structure but different dimensions is employed to fabricate LPGs in it.In this paper, we experimentally demonstrate an MZI based on an intermodal interference in the simplified HCPCF by simply splicing the HCPCF to SMFs with an appropriate core-offset [3]. Thanks to the special structure of the simplified HCPCF and air-guided property, the MZI shows almost insensitive to temperature, as low as 0±0.5 pmrC, but relatively high sensitivity to axial strain (-2.29 pmll-l£). This device has a promising application as a temperature-independent strain sensor. Fig. 1. Cross-section of the simplified HCPCF. Fig. 2. Transmission spectrum of the MZIF.The simplified HCPCF used in our experiments is same as that in Ref. [2]. As shown in Fig. 1, it has a hexagonal hollow core and only one layer air-holes cladding. The diameters of the core, air-holes cladding and outer cladding are about 22 I-lm, 70 I-lm and 140 I-lm, respectively. The thickness of silica walls separating holes is no more than 370 nm.According to the mode investigation reported in [2], this simplified HCPCF can guide light with different modes. By means of appropriate core-offset, not only fundamental core mode but also some higher-order modes will be excited simultaneously. Since the fundamental core mode and higher-order modes have different effective refractive indices, the phase difference will be accumulated after propagating through a certain length of HCPCF. Finally, the interference is generated when they are coupled from the PCF to SMF. Fig. 2 illustrates the transmission spectrum of an interferometer containing a ,,-,29.65 mm length of the simplified HCPCF. As shown, the insertion loss of the MZI is about 7.5 dB, the extinction ratio ranges from "-' 10 dB to 17 dB, and the average fringe spacing is about 38 nm.Then, the sensing experiments are performed. When the interferometer is tensioned by increasing force, all the dips undergo similar wavelength-shift. Here, we characterize the strain-sensing performance of the MZI by monitoring the