Core-needle biopsy performed by the cytopathologist

Domanski, Henryk A.; Åkerman, Måns; Carlén, Birgitta; Engellau, Jacob; Gustafson, Pelle; Jonsson, Kjell; Mertens, Fredrik; Rydholm, Anders

doi:10.1002/cncr.21154

Cited by 94 publications

(11 citation statements)

References 25 publications

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“…Compared to an open biopsy, both CNB and FNA are less invasive, cause fewer potential complications, and are less expensive. [ 8 16 17 ] With FNA, it is easy to sample material from different parts of large tumors, as compared with biopsies. FNA smears are well-suited for rapid staining and quick preliminary diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…The overall diagnostic accuracy of fine-needle aspiration (FNA) varies 62-84% in different studies. [ 5 6 7 8 9 10 11 ]…”

Section: Introductionmentioning

confidence: 99%

“…The combined FNAC and CNB of the musculoskeletal neoplasms permits a rapid and accurate preliminary diagnosis by combining the cytomorphological features and evaluation of tumor tissue architecture. [ 8 ] The purpose of this study was to compare the efficacy of FNAC and CNB in the diagnosis of musculoskeletal neoplasms. Further, the results were compared with the histopathological examination of surgical specimens.…”

Section: Introductionmentioning

confidence: 99%

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Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms

Kaur

Handa

Kundu

et al. 2016

J Cytol

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Background:The management of musculoskeletal neoplasms requires an accurate diagnosis, histologic type, and degree of tumor differentiation.Aim:The present study was undertaken to compare the accuracy of fine-needle aspiration cytology (FNAC) and core needle biopsy (CNB) in the diagnosis of musculoskeletal tumors and further to compare the results with histopathological examination of surgical specimens. Grading of malignant tumors was also compared on these techniques.Materials and Methods:This prospective study was conducted on 50 patients with musculoskeletal neoplasms. Detailed history, clinical examination, and radiological investigations were undertaken. FNAC followed by CNB were performed in each case. The tumors were categorized as benign and malignant with a definitive histotype diagnosis. For malignant neoplasms, cytologic and histologic gradings were done into three grades. The sensitivity and specificity of FNAC and CNB were compared.Results:Of the 50 cases with musculoskeletal neoplasms, 32 (64%) were bone tumors and 18 (36%) were soft tissue tumors. The sensitivity of FNAC and CNB for categorizing bone tumors into benign and malignant was 94.7%. For soft tissue tumors, FNAC had a sensitivity of 90.9% and CNB had a sensitivity of 100%. The specificity of both the techniques, FNA and CNB for bone and soft tissue tumors was 100%. For malignant bone tumors, cytologic grade was concordant with CNB grade in 72.2% of the cases. Cytologic grade was concordant with the grade on CNB in 81.8% cases for malignant soft tissue neoplasms.Conclusion:FNAC and CNB alleviate the need for an open biopsy in diagnosing and grading musculoskeletal neoplasms, thus facilitating appropriate therapeutic intervention.

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Section: Discussionmentioning

confidence: 99%

“…The overall diagnostic accuracy of fine-needle aspiration (FNA) varies 62-84% in different studies. [ 5 6 7 8 9 10 11 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms

Kaur

Handa

Kundu

et al. 2016

J Cytol

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“…Although highly sensitive overall, these small biopsies may be nondiagnostic or may erroneously provide a lower tumor grade because of sampling error (13,29,30). In our practice, we have, on occasion, encountered such sampling errors.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by ¹⁸F-FDG PET

Benz¹,

Dry²,

Eilber³

et al. 2010

J Nucl Med

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Tumor glycolytic phenotyping can be accomplished with 18F-FDG PET. Tumor 18F-FDG uptake correlates with tumor grade in several cancers. However, the role of 18F-FDG PET for the grading of soft-tissue sarcomas (STSs) warrants further research. Methods One hundred two patients (48 men and 54 women; mean age ± SD, 50 ± 17 y) with 12 STS subtypes underwent 18F-FDG PET/CT before treatment. Tumor 18F-FDG uptake, expressed as maximum standardized uptake value (SUVmax), was compared among subtypes and correlated with histopathologic grade. Two frequently used sarcoma grading systems—the 3-tier system of the French Federation of Cancer Centers Sarcoma Group (Fédération Nationale des Centres de Lutte Contre le Cancer [FNCLCC]) and a 2-tier system (low grade vs. high grade)—were used. Results More than 90% of STSs (93/102) exhibited a strong glycolytic phenotype (SUV-max, 2.7–52.2 g/mL). Tumor SUVmax differed significantly among tumor grades (P < 0.001 for the 3- and 2-tier grading systems). The FNCLCC and 2-tier grading systems predicted tumor grade with similar accuracy (area under the curve, 0.83 and 0.85, respectively; P = 0.35). SUVmax differed significantly among histologic subtypes (P = 0.03) in the entire population but not when high-grade STSs were analyzed separately (P = 0.31). Conclusion The tumor glycolytic phenotype correlated significantly with histologic grade as determined by both the FNCLCC and 2-tier (high vs. low) grading systems. 18F-FDG PET cannot be used to reliably distinguish among grade 2 and 3 STSs (by FNCLCC) and the various subtypes.

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“…Domanski et al . (2005) 6 reported an accuracy of 77% for fine needle aspiration combined with core needle biopsy. Clearly, incisional biopsy is not an inferior technique for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Open incisional biopsy is a safe and accurate technique for soft tissue tumours

Clayer

2010

ANZ Journal of Surgery

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Core-needle biopsy performed by the cytopathologist

Cited by 94 publications

References 25 publications

Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms

Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms

Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by ¹⁸F-FDG PET

Open incisional biopsy is a safe and accurate technique for soft tissue tumours

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Core-needle biopsy performed by the cytopathologist

Cited by 94 publications

References 25 publications

Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms

Role of fine-needle aspiration cytology and core needle biopsy in diagnosing musculoskeletal neoplasms

Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by 18F-FDG PET

Open incisional biopsy is a safe and accurate technique for soft tissue tumours

Contact Info

Product

Resources

About

Correlation Between Glycolytic Phenotype and Tumor Grade in Soft-Tissue Sarcomas by ¹⁸F-FDG PET