Core Needle Biopsy and Fine Needle Aspiration Alone or in Combination: Diagnostic Accuracy and Impact on Management of Renal Masses

Cate, Frances; Kapp, Meghan E.; Arnold, Shanna A.; Gellert, Lan L.; Hameed, Omar; Clark, Peter E.; Wile, Geoffrey; Coogan, Alice; Giannico, Giovanna A.

doi:10.1016/j.juro.2017.01.038

Cited by 10 publications

(5 citation statements)

References 28 publications

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“…However, in our experience, the CNB procedure required that the nodule dimension be ≥3 cm, thus representing a limitation in its routine application. The higher sensitivity of CNB compared to FNAC in detecting malignancy was also confirmed in other human tumors ( 35 – 38 ).…”

Section: Discussionmentioning

confidence: 56%

Core Needle Biopsy Can Early and Precisely Identify Large Thyroid Masses

et al. 2022

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BackgroundLarge thyroid masses, particularly if rapidly growing, are often characterized by compression and infiltration of the vital structures of the neck. Therefore, an early and precise diagnosis, not only of malignancy but also of histotype, is mandatory to set up the right therapy. The aim of this study was to evaluate the diagnostic performance of fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) in this setting.Patients and MethodsWe prospectively evaluated 95 patients with large and rapidly growing thyroid masses admitted to the University Hospital of Pisa between April 2014 and January 2020. All patients were submitted to FNAC and CNB in the same session. The ability of both procedures to diagnose the malignancy of the lesions, particularly the histotype, and to obtain sufficient material to perform molecular analysis was evaluated.ResultsFNAC obtained adequate tumor sample to reach a diagnosis in 76 of 95 (80%) patients, while a higher percentage was obtained with CNB (92/95, 96.8%). FNAC was able to identify the malignancy of the lesion in 74 of 95 (77.9%) cases, but only in 16 of 74 (21.6%) cases was it able to define the histotype. CNB was able to define the malignancy of the lesion in all but three cases (92/95, 96.8%), and in all specimens, the histotype was identified. Moreover, in all cases, the material extracted from CNB was optimal to perform molecular analysis. No surgery-related complications were experienced with both procedures.ConclusionsCNB is a rapid and safe procedure with higher performance compared to FNAC in identifying the histotype of large and rapidly growing thyroid masses. Moreover, adequate material can be obtained to characterize the molecular profile for the treatment of potentially lethal cancers. In the era of precision medicine, CNB should be introduced in routine clinical practice as a key procedure for an early diagnosis and therapy of these diseases.

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Section: Discussionmentioning

confidence: 56%

Core Needle Biopsy Can Early and Precisely Identify Large Thyroid Masses

et al. 2022

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“…251 Inadequacy rates of either FNAB or CNB can be reduced by combining the 2 techniques. 252 For FNAB containing spindle cells, immunocytochemistry may increase diagnostic specificity, 253 and for lymphoid lesions, flow cytometry. 254…”

Section: Kidneymentioning

confidence: 99%

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care

Pritzker

Nieminen

2019

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Needle biopsy of diseased tissue is an essential diagnostic tool that is becoming even more important as precision medicine develops. However, the capability of this modality to efficiently provide samples adequate for diagnostic and prognostic analysis remains quite limited relative to current diagnostic needs. For physicians and patients, inadequate biopsy frequently leads to diagnostic delay, procedure duplication, or insufficient information about tumor biology leading to delay in treatment; for health systems, this results in substantial incremental costs and inefficient use of scarce specialized diagnostic resources. Objective.— To review current needle biopsy technology, devices, and practice with a perspective to identify current limitations and opportunities for improvement in the context of advancing precision medicine. Data Sources.— PubMed searches of fine-needle aspiration and core needle biopsy devices and similar technologies were made generally, by tissue site, and by adequacy as well as by health economics of these technologies. Conclusions.— Needle biopsy adequacy can be improved by recognizing the importance of this diagnostic tool by promoting common criteria for needle biopsy adequacy; by optimizing needle biopsy procedural technique, technologies, clinical practice, professional education, and quality assurance; and by bundling biopsy procedure costs with downstream diagnostic modalities to provide better accountability and incentives to improve the diagnostic process.

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“…Core needle biopsy (CNB) represents the gold standard for tumour samplings and is performed using semi‐automatic or automatic cutting needles of 18 or 16 Gauge (G) calibres to obtain tumour fragment. When the lesion is inaccessible to biopsy, a fine‐needle aspiration (FNA) may be feasible percutaneously or endoscopically [5,6]. FNA is a minimally invasive sampling technique that can be performed on an outpatient basis and generally requires needles of 25–20 Gauge.…”

Section: Introductionmentioning

confidence: 99%

Fine‐needle aspiration as an alternative to core needle biopsy for tumour molecular profiling in precision oncology: prospective comparative study of next‐generation sequencing in cancer patients included in the SHIVA02 trial

Dupain

Masliah‐Planchon

et al. 2020

Molecular Oncology

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Core Needle Biopsy and Fine Needle Aspiration Alone or in Combination: Diagnostic Accuracy and Impact on Management of Renal Masses

Abstract: Fine needle aspiration plus core needle biopsy vs at least fine needle aspiration alone may improve diagnostic yield when sampling renal masses but it has subtyping potential similar to that of core needle biopsy only.

Cited by 10 publications

References 28 publications

Core Needle Biopsy Can Early and Precisely Identify Large Thyroid Masses

Core Needle Biopsy Can Early and Precisely Identify Large Thyroid Masses

Needle Biopsy Adequacy in the Era of Precision Medicine and Value-Based Health Care

Fine‐needle aspiration as an alternative to core needle biopsy for tumour molecular profiling in precision oncology: prospective comparative study of next‐generation sequencing in cancer patients included in the SHIVA02 trial

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