“…It has been demonstrated that crosslinked biodegradable micelles have advantageous properties like high drug loading efficiency, superior stability upon dilution, prolonged circulation time, and enhanced drug accumulation at the tumor site [26,27,28]. Very recently, we prepared photocrosslinked pH-sensitive biodegradable micelles based on poly(ethylene glycol)-poly(2,4,6-trimethoxybenzylidene-pentaerythritol carbonate-co-acryloyl carbonate) [PEG-P(TMBPEC-co-AC)] copolymers, which had superior extracellular stability by UV crosslinking of AC units, and fast intracellular drug release through the acidlabile TMBPEC components [29]. These photo-crosslinked micelles provided with galactose units enhanced drug accumulation in the human hepatoma SMMC-7721 tumor and exerted more efficient antitumor activity, as compared to non-crosslinked micelles as well as non-targeted micelles [30].…”