2012
DOI: 10.1016/j.jconrel.2012.07.011
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Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma

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Cited by 160 publications
(111 citation statements)
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“…After micelles cross-linking, they are found to be stable against disassociation under high dilution, and their aggregation is independent of external influences such as changes in pH values and other interference. [26][27][28][29][30][31][32][33] Recently, Liao et al designed core cross-linked polymer micelles carrying DOX, camptothecin and cisplatin for single-nanoparticle combination cancer therapy, but the system was difficult to synthesize. 34 As compared to core cross-linked micelles, SCL micelles are facile to load drug via physical entrapment.…”
Section: Introductionmentioning
confidence: 99%
“…After micelles cross-linking, they are found to be stable against disassociation under high dilution, and their aggregation is independent of external influences such as changes in pH values and other interference. [26][27][28][29][30][31][32][33] Recently, Liao et al designed core cross-linked polymer micelles carrying DOX, camptothecin and cisplatin for single-nanoparticle combination cancer therapy, but the system was difficult to synthesize. 34 As compared to core cross-linked micelles, SCL micelles are facile to load drug via physical entrapment.…”
Section: Introductionmentioning
confidence: 99%
“…It has been demonstrated that crosslinked biodegradable micelles have advantageous properties like high drug loading efficiency, superior stability upon dilution, prolonged circulation time, and enhanced drug accumulation at the tumor site [26,27,28]. Very recently, we prepared photocrosslinked pH-sensitive biodegradable micelles based on poly(ethylene glycol)-poly(2,4,6-trimethoxybenzylidene-pentaerythritol carbonate-co-acryloyl carbonate) [PEG-P(TMBPEC-co-AC)] copolymers, which had superior extracellular stability by UV crosslinking of AC units, and fast intracellular drug release through the acidlabile TMBPEC components [29]. These photo-crosslinked micelles provided with galactose units enhanced drug accumulation in the human hepatoma SMMC-7721 tumor and exerted more efficient antitumor activity, as compared to non-crosslinked micelles as well as non-targeted micelles [30].…”
Section: Introductionmentioning
confidence: 99%
“…Other core-crosslinked pH-sensitive degradable micelles were synthesized based on poly(ethylene glycol)-b-poly(mono-2,4,6-trimethoxy benzylidenepentaerythritol carbonate-co-acryloyl carbonate) (PEG-b-P(TMBPEC-co-AC) copolymer that contains acid-labile acetal and photo-cross-linkable acryloyl groups in the hydrophobic polycarbonate block for intracellular paclitaxel (PTX) release. The in vitro release studies showed that rapid drug release was obtained under mildly acidic conditions, whereas PTX release at pH 7.4 was greatly inhibited [71]. A pH-sensitive mixed copolymer micelles system, composed of hyaluronic acid-g-poly(l-histidine) (HA-PHis) and d-α-tocopheryl polyethylene glycol 2000 (TPGS2k), an inhibitor of the efflux pumps, was developed to co-deliver doxorubicin and TPGS2k into drug-resistant breast cancer MCF-7 cells.…”
Section: Targeting Microenvironmental Stressorsmentioning
confidence: 99%