Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD)

Defer, G.; Widner, Håkan; Marié, Rose‐Marie; Rémy, Philippe; Levivier, Marc

doi:10.1002/1531-8257(199907)14:4<572::aid-mds1005>3.0.co;2-c

Cited by 746 publications

(519 citation statements)

References 82 publications

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“…The comparison of the demographic and clinical features of the patients from the two centres didn't show any statistically significant difference ( See Esupp Table 2), so patients were lumped together for further analyses. All patients had a diagnosis of idiopathic PD and fulfilled inclusion and exclusion criteria proposed by the CAPSIT-PD [9]. The eligible patients signed an informed consent before entering the study.…”

Section: Methodsmentioning

confidence: 99%

Long-term outcome of subthalamic nucleus DBS in Parkinson's disease: From the advanced phase towards the late stage of the disease?

Rizzone

Fasano

Daniele

et al. 2014

Parkinsonism & Related Disorders

160

152

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Background: Deep Brain Stimulation of the Subthalamic Nucleus (STN-DBS) is an effective treatment for Parkinson's disease (PD), but only few studies investigated its long-term efficacy. Furthermore, little is known about the role of PD-subtype on STN-DBS long-term outcome.Objective: To report the results of a long-term follow-up (mean 11 years, range 10-13) on 26 patients bilaterally implanted in two centres. Methods:Patients were assessed preoperatively and 1, 5 and 11 years after the implant by the Unified Parkinson's Disease Rating Scale (UPDRS) and a battery of neuropsychological tests. Stimulation parameters, drugs dosages, non-motor symptoms and adverse events were also recorded.Results: At 11 years, stimulation significantly improved the motor symptoms by 35.8%, as compared to the preoperative off-state. Motor complications were well controlled, with a 84.6% improvement of dyskinesias and a 65.8% improvement of motor fluctuations. Despite this, the UPDRS-II-on score worsened by 88.5%, mainly for the worsening of poorly levodopa-responsive symptoms. More than 70% of the patients performed in the normal range in most of the neuropsychological tests, despite the development of dementia in 22.7%. Age at disease onset, axial subscore in off-condition and presence of REM behaviour disorder at baseline were found to be associated with a higher risk of developing disability over time. Conclusions:Our study confirms the long-term safety and efficacy of STN-DBS in PD. Nevertheless, the functionality of patients worsens over time, mainly for the onset and progression of levodopa-resistant and non-motor symptoms. The role of PD-subtype seems to be relevant in the long-term outcome.

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Section: Methodsmentioning

confidence: 99%

Long-term outcome of subthalamic nucleus DBS in Parkinson's disease: From the advanced phase towards the late stage of the disease?

Rizzone

Fasano

Daniele

et al. 2014

Parkinsonism & Related Disorders

160

152

View full text Add to dashboard Cite

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“…Subjects were selected according to the Core Assessment Program for Surgical Interventional Therapies in Parkinson's disease (CAPSIT-PD) [9] and STN-DBS bilateral surgery was performed following the procedure previously described elsewhere [10] .…”

Section: Methodsmentioning

confidence: 99%

Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients

et al. 2014

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“…After overnight medication withdrawal, patients received 125% of their usual morning levodopa equivalent dose as immediate release levodopa/carbidopa. The assessment in each video-recorded session consisted of a complete UPDRS III and CAPSIT dyskinesia scale [16]. LID was assessed individually in the face, neck, trunk, and right and left upper and lower limbs, and was scored as follows: 0, none; 1, mild; 2, moderate; 3, severe; and 4, extreme (0e28).…”

Section: Cerebellar Ctbsmentioning

confidence: 99%

Metabolic changes induced by theta burst stimulation of the cerebellum in dyskinetic Parkinson’s disease patients

Brusa

Ceravolo

Kiferle

et al. 2012

Parkinsonism & Related Disorders

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a b s t r a c tBackground: Cerebellar repetitive transcranial magnetic stimulation may be effective in reducing peakdose levodopa induced dyskinesia in Parkinson's disease patients. It was proposed that the antidyskinetic effect could be due to modulation of cerebello-thalamo-cortical pathways. However the neural basis for these clinical effects have not yet been demonstrated. Methods: We investigated the effects of repeated sessions of cerebellar continuous theta burst stimulation in Parkinson's disease patients with levodopa induced dyskinesia on brain metabolism by means of positron emission tomography scan with fluorodeoxyglucose ( 18 F-FDG) to characterize the specific cerebral network activated by cerebellar stimulation in these patients. Results: We found that five days of bilateral cerebellar continuous theta burst stimulation (cTBS) were effective in reducing levodopa induced dyskinesia. Clinical changes were paralleled by a reduction of 18 F-FDG metabolism in the cerebellum as revealed by positron emission tomography imaging. We found a global decrease in the metabolism of the bilateral cerebellar hemispheres, and a significant decrease in 18 F-FDG uptake in correspondence of bilateral dentate nucleus.Conclusions: Our study demonstrates the antidyskinetic effect of cerebellar cTBS in Parkinson's disease patients with levodopa induced dyskinesia, is paralleled by modulation of the activity of the pathways connecting the cerebellar cortex with the deep cerebellar nuclei, confirming the hypothesis that the motor cerebellar circuit is involved in the generations of levodopa induced dyskinesia.

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Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD)

Cited by 746 publications

References 82 publications

Long-term outcome of subthalamic nucleus DBS in Parkinson's disease: From the advanced phase towards the late stage of the disease?

Long-term outcome of subthalamic nucleus DBS in Parkinson's disease: From the advanced phase towards the late stage of the disease?

Subthalamic deep brain stimulation: clinical and neuropsychological outcomes in mild cognitive impaired parkinsonian patients

Metabolic changes induced by theta burst stimulation of the cerebellum in dyskinetic Parkinson’s disease patients

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