Core and adjunctive interventions for osteoarthritis: efficacy and models for implementation

Bowden, Jocelyn L.; Hunter, David J.; Duong, Vicky; Dziedzic, Krysia; Allen, Kelli D.; Chan, PK; Eyles, Jillian

doi:10.1038/s41584-020-0447-8

Cited by 44 publications

(32 citation statements)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Up to now, no treatment have been proven to stop or delay satisfactorily the progression of the disease [15]. Nonoperative treatment, mainly aimed at symptoms alleviation, comprises weight loss [16,17], low-impact aerobic exercise [14,18,19], physical therapy [20],…”

Section: Introductionmentioning

confidence: 99%

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Fantoni

Biz

Fan

et al. 2021

Life

View full text Add to dashboard Cite

The present study compares the structure and composition of fascia lata in healthy subjects and in patients with hip osteoarthritis (OA), to evaluate any differences in the amount of Collagen type I, Collagen type III, and Hyaluronan. Fascia lata samples from voluntary healthy subjects and patients with OA were harvested during surgery. Collagen type I (COL I), III (COL III) antibody, and biotinylated hyaluronan binding protein (HABP) immunohistochemistry stainings were used to evaluate fascial morphology and COL I, COL III, and Hyaluronan (HA) content in both groups. Ten samples from healthy subjects and 11 samples from OA patients were collected. COL I was significantly more abundant in the OA group (p = 0.0015), with a median percentage positivity of 75.2 (IQR 13.11)%, while representing only 67 (IQR: 8.71)% in control cases. COL III, with median values of 9.5 (IQR 3.63)% (OA group) and 17.10 (IQR 11)% (control cases), respectively, showed significant reduction in OA patients (p = 0.002). HA showed a median value of 10.01 (IQR 8.11)% in OA patients, denoting significant decrease (p < 0.0001) with respect to the control group median 39.31 (IQR 5.62)%. The observed differences suggest a relationship between fascial pathology and hip OA. The observed increase in COL I in OA patients, along with the reduction of COL III and HA, could lead to fascial stiffening, which could alter fascial mechanics and be linked to the development and symptoms of OA.

show abstract

Section: Introductionmentioning

confidence: 99%

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Fantoni

Biz

Fan

et al. 2021

Life

View full text Add to dashboard Cite

show abstract

“…During this period, there have been continual re nements in the frequency, duration and nature of the exercises [11] along with the addition of self-management components which aim to provide reassurance about the value of exercise in OA [17]. While there has been some focus on adjunctive therapies [18], such as cognitive-behavioural therapy [19,20], there has been very little research investigating biopsychosocial interventions for knee OA [21], despite suggestions that this may improve clinical management [22,23]. This is particularly concerning given the evidence of strong links between psychosocial factors and clinical pain/disability in this disease.…”

Section: Discussionmentioning

confidence: 99%

Tension Release Therapy: The Development of a New Integrated Behavioural Intervention for Knee Osteoarthritis

Preece

Brookes

Williams

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Exercise-based approaches have been a cornerstone of physiotherapy management of knee osteoarthritis for many years. However, the magnitude of clinical effect is considered small to modest and the need for continued adherence identified as a barrier to clinical efficacy. While many exercise-based approaches incorporate an educational/coping component alongside muscle strengthening, there has been no previous attempt to integrate psychological techniques with muscle retraining. Building on these ideas, the aim of this study was to create a new integrated behavioural intervention for knee osteoarthritis, suitable for delivery by a physiotherapist.Methods: Through literature review, we created a framework linking theory from pain science with emerging biomechanical concepts related to knee muscle co-contraction. Using recognised behaviour change theory, we then mapped a set of intervention components which were iteratively developed through ongoing testing and consultation with users.Results: The underlying framework incorporated ideas related to central sensitisation to pain, maladaptive motor responses to pain and also focused on the idea that increased knee muscle co-contraction could result from changes in postural tone. Building on these ideas, we created an intervention with five components: making sense of pain, general relaxation, postural deconstruction, responding differently to pain and functional muscle retraining. The intervention incorporated a range of animated instructional videos to communicate concepts related to pain and biomechanical theory and also used EMG biofeedback to enable patients to visualise muscle patterns. User feedback was positive with patients describing the intervention as enabling them to “create a new normal” and to be “in control of their own treatment.” Furthermore, large reductions in pain were observed from 11 patients who received a full prototype version of the intervention. Conclusion: We have created a new intervention for knee osteoarthritis, designed to empower individuals with capability and motivation to change muscle patterns and beliefs associated with pain. Preliminary feedback and clinical indications are positive, and this motivates future large-scale trials to understand potential efficacy. It is possible that this new approach could bring about improvements in the pain associated with knee osteoarthritis without the need for continued adherence to a muscle strengthening programme. Trial Registration: ISRCTN51913166 (Registered 24-02-2020, Retrospectively registered)

show abstract

“…Osteoarthritis (OA) is a common degenerative joint disease associated with aging. OA compromises the quality-of-life and causes disabilities [1,2]. OA is characterized by infiltration of immune cells into cartilage, progressive cartilage destruction, and chronic pain [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death

Woo

Kim³

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Background Osteoarthritis (OA) is the most common degenerative joint disease and is characterized by breakdown of joint cartilage. Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation. However, any effect of CoQ10 on OA remains unclear. Here, we investigated the therapeutic utility of CoQ10-micelles. Methods Seven-week-old male Wistar rats were injected with monosodium iodoacetate (MIA) to induce OA. CoQ10-micelles were administered orally to MIA-induced OA rats; celecoxib served as the positive control. Pain, tissue destruction, and inflammation were measured. The expression levels of catabolic and inflammatory cell death markers were assayed in CoQ10-micelle-treated chondrocytes. Results Oral supplementation with CoQ10-micelles attenuated OA symptoms remarkably, including pain, tissue destruction, and inflammation. The expression levels of the inflammatory cytokines IL-1β, IL-6, and MMP-13, and of the inflammatory cell death markers RIP1, RIP3, and pMLKL in synovial tissues were significantly reduced by CoQ10-micelle supplementation, suggesting that CoQ10-micelles might attenuate the synovitis of OA. CoQ10-micelle addition to cultured OA chondrocytes reduced the expression levels of catabolic and inflammatory cell death markers. Conclusions CoQ10-micelles might usefully treat OA.

show abstract

Core and adjunctive interventions for osteoarthritis: efficacy and models for implementation

Cited by 44 publications

References 129 publications

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Fascia Lata Alterations in Hip Osteoarthritis: An Observational Cross-Sectional Study

Tension Release Therapy: The Development of a New Integrated Behavioural Intervention for Knee Osteoarthritis

Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death

Contact Info

Product

Resources

About