Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators

Kumar, Rajesh; Negi, P. S.; Singh, Bhagwat; Ilavazhagan, G.; Bhargava, Kalpana; Sethy, Niroj Kumar

doi:10.1016/j.jep.2011.04.040

Cited by 53 publications

(45 citation statements)

References 29 publications

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“…(Kumara et al, 2011). Polysaccharide exhibited antioxidative and antitumor activities, and regulating immune functions (Paterson, 2008).…”

Section: Introductionmentioning

confidence: 99%

Optimum Fermentation Condition of Soybean Curd Residue and Rice Bran by Preussia aemulans using Solid-State Fermentation Method

Li¹,

Meng²,

Wang³

et al. 2015

IJB

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An environmental method for using soybean curd residue (SCR) and rice bran (RB) was developed in this study. SCR and RB were utilized as growth medium for Preussia aemulans, a new fungus isolated from Cordyceps sinensis fruiting body. According to Orthogonal test and Duncan's multiple range test, the optimum fermentation condition of fermented SCR and RB for producing polysaccharide, adenosine and ergosterol were summarized. Under the optimum fermentation condition of SCR, the polysaccharide, adenosine and ergosterol contents were reached to 39.18 ± 1.06 mg/g dry matter, 127.94 ± 1.82 mg/100g dry matter and 37.53 ± 0.11 mg/100g dry matter, respectively. And under the optimum fermentation condition of RB, the content of polysaccharide, adenosine and ergosterol were also enhanced 3-fold, 10-fold and 10-fold, respectively. Therefore, the fermented SCR and RB could be utilized as nutritious functional food or food additives in the future.

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“…(Kumara et al, 2011). Polysaccharide exhibited antioxidative and antitumor activities, and regulating immune functions (Paterson, 2008).…”

Section: Introductionmentioning

confidence: 99%

Optimum Fermentation Condition of Soybean Curd Residue and Rice Bran by Preussia aemulans using Solid-State Fermentation Method

Li¹,

Meng²,

Wang³

et al. 2015

IJB

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“…polysaccharide, glycopeptide, showed powerful immunomodulatory, anti-inflammatory, and antioxidative activities [30,31,32,33]. Furthermore, Ophiocordyceps sinensis revealed the improvement of an exercise endurance capacity of rats by activating not only the skeletal muscle metabolic regulators but also a coordinated antioxidative response [9].…”

Section: Discussionmentioning

confidence: 99%

“…Surprisingly, the OSM use in this study also decreased the liver TG levels, but it did not enhance (p>0.05) the TG output in feces, so it may not be related to lipase activities. Probably, the decreased liver TG levels by OSM treatment may be related to the energy expenditure in hepatic or other tissues like skeletal muscle [9]. It has been proclaimed the Cordymin, a compound in OS, could enhance the mitochondria biogenesis in livers [40,41].…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous studies, the bioactivities of OS and OSM were found as immunomodulation [3], anti-inflammation [4], anti-tumor [5], antioxidation [6], cardiovascular-protection [6], anti-fibrosis [7], and regulating male reproductive function [8]. Besides, the evidences for exercise-endurance promotion and anti-fatigue activities of OS were demonstrated, and it meditated upregulation of some metabolic regulators, such as AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1), and peroxisome proliferator activated receptor (PPAR), in the skeletal muscle [9]. Recently, it was reported that cordycepin, one nucleotide derivatives in OS, could activate AMPK in HepG2 cells and then decrease intracellular lipid accumulation [10].…”

Section: Introductionmentioning

confidence: 99%

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Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

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Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

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“…Mice were placed in a swimming tank (50 cm × 50 cm × 40 cm) with 30 cm deep water and subjected to swim-training at 30℃ water after the sample administration. During the exercise protocol, the mice in the control group were kept in a plastic cage containing approximately 3 cm of water maintained at the same temperature to exclude potential stress and other potential confounding effects (Kumar et al, 2011). The training lasted for 14 d. During the first 2 d, the mice swam for 20 min.…”

Section: Methodsmentioning

confidence: 99%

In Vitro Antioxidant Activity and In Vivo Anti-fatigue Effects of Oyster (Ostrea plicatula Gmelin) Peptides Prepared Using Neutral Proteinase

Hao

Cao

Hao

et al. 2013

FSTR

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The amino acid profile of oyster (Ostrea plicatula Gmelin) peptides (OP) was assayed. Its in vitro antioxidant activity was determined, and its in vivo anti-fatigue activity was compared with those of oyster meat and oyster protein. Seven amino acids that may play an important role in enhancing antioxidant activity account for 25.8% of total OP content. These amino acids are histidine, proline, methionine, cysteine, tyrosine, tryptophan, and phenylalanine. The F-value of OP was 4.89, and the concentration of taurine was 45.43 mmol/mL. OP acted as a scavenger for hydroxyl radicals, 1,1-diphenyl-2-picrylhydrazyl, and superoxide anion radicals. It also inhibited lipid peroxidation. The intragastric administration of OP prolonged the swimming time to exhaustion of mice by 78% over that of the control. It decreased the levels of serum lactic acid and blood urea nitrogen by 24.8% and 11.2%, respectively. Finally, it increased the levels of liver glycogen (1.0-fold) and gastrocnemius muscle glycogen (55.6%).Keywords: oyster peptides, antioxidant activity, anti-fatigue effect, endurance exercise *To whom correspondence should be addressed. E-mail: zhangch2@139.com IntroductionAcute and/or chronic exercises are associated with increases in free radicals and ROS production, which are due primarily to the increase in oxygen uptake by active tissues (Ji, 1995;Powers and Jackson, 2008). The imbalance between free radical/ROS production and its removal by antioxidant defense systems causes oxidative stress (Chalamaiah et al., 2012). Oxidative stress may lead to potential damage and consequently diminish athletic performance. Thus, increased free radical/ROS production has been associated with altered muscle function and elevated rates of muscle fatigue (Deaton and Marlin, 2003).Research consensus reflects support for the idea that antioxidative peptides can reduce the damage induced by ROS and free radicals. The antioxidative peptides from aquatic products have become of recent concern because they are considered safe and healthy molecules with low molecular weight, easy absorption, low cost, and high activity (Sarmadi and Ismail, 2010). The precursor protein in these peptides is mostly inactive. These active peptides can also be released from the precursor protein by hydrolysis techniques, such as enzymatic hydrolysis, autolytic process using endogenous enzymes, and microbial fermentation (Chalamaiah et al., 2012;Je et al., 2007;Rajapakse et al., 2005;Kim et al., 2007).In this study, we assayed the amino acid profile of oyster peptides (OP), and then investigated its in vitro antioxidant activities and the in vivo anti-fatigue effects of OP previously prepared by neutral proteinase digestion. The in vitro antioxidant activities were studied by determining the activities of hydroxyl radicals, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and superoxide anion radical scavengers, as well as lipid peroxidation inhibitory activity in a linoleic acid emulsion system. In the determination, glutathione (GSH) which is a well known peptide an...

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Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators

Cited by 53 publications

References 29 publications

Optimum Fermentation Condition of Soybean Curd Residue and Rice Bran by Preussia aemulans using Solid-State Fermentation Method

Optimum Fermentation Condition of Soybean Curd Residue and Rice Bran by Preussia aemulans using Solid-State Fermentation Method

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

In Vitro Antioxidant Activity and In Vivo Anti-fatigue Effects of Oyster (Ostrea plicatula Gmelin) Peptides Prepared Using Neutral Proteinase

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