Cordyceps

Holliday, John C.; Cleaver, Matt P.; Tajnik, Mojca; Cerecedes, Joseph; Wasser, Solomon P.

doi:10.1201/b14669-26

Cited by 8 publications

(10 citation statements)

References 8 publications

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“…1. At present, there are more than 680 species coming under the genus Cordyceps (Holliday, Cleaver, & Wasser, 2005) but usually Cordyceps refers precisely to the species C. sinensis (Holliday & Cleaver, 2008;Mizuno, 1999). Both dead larva and fruiting body have been used as a traditional medicine and health food for hundreds of years for ''lung invigoration and kidney nourishment'' in China (Dong & Yao, 2007;Kuo et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Shashidhar

Giridhar

Sankar

et al. 2013

Journal of Functional Foods

102

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Extraction Health benefits A B S T R A C T Cordyceps sinensis (CS) is a well-known entamophagus fungus, naturally distributed in the Tibetan Plateau of Asia and Himalayas. Recently this synonym is transferred to Ophiocordyceps by both scientific and non-scientific communities. It is widely used as a tonic and medicinal food in traditional Chinese medicine (TCM), as it possess wonderful health benefits. To support its functional attributes, various investigations have been carried out to find out its adaptogenic, aphrodisiac, anti-oxidant, anti-aging, neuroprotective, nootropic, immunomodulatory, anti-cancer and hepatoprotective role. Its fruiting portion as well as the larvae possesses potent bio-active fractions and their composition almost found to be similar in both. The bioactive principles are nucleosides, exo-polysaccharides, sterols and, proteins, among others. Among nucleosides, adenosine and cordycepin are the major biochemical markers. Further, different types of solvent extracts and their mixtures exhibit wide range of pharmacological activities, while the water and methanol extracts with the richest sources of nucleosides and polysaccharides also show wide range of pharmacological activities. This review gives a panoramic view of potential health benefits of various classes of bio-active fractions along with the need for sustainable management of CS for human wellness.

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Section: Introductionmentioning

confidence: 99%

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Shashidhar

Giridhar

Sankar

et al. 2013

Journal of Functional Foods

102

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“…Lie et al (2005) reported non toxic nature of polysaccharide from O. sinensis in test for animal mass, biochemical properties of blood, and histopathological changes of liver and kidney. Further, for median lethal does (LD 50 ), mice injected up to 80 g/kg per day, did not show any fatalities after 7 days of treatment (Holliday et al 2005). Meena et al (2013) also highlighted on non toxic nature of laboratory cultured mycelia of O. sinensis oral administration up to 2 g/kg body weight in adult female Wister rats.…”

Section: Dose and Toxicitymentioning

confidence: 97%

Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir

Shrestha¹,

Shrestha²,

Lee

et al. 2014

Nepal Journal of Science and Technology

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Yarsagumba (Ophiocordyceps sinensis (Berk.) Sung et al.) is a well-known entomogenous fungus native to alpine nival terrain of trans-Himalaya and Tibetan Plateau. The traditional use of O. sinensis in Ayurvedic medicine as well as in traditional Chinese medicine for range of human health requirements with well documented evidences are themselves testimony of its value. It is regarded as winter worm, summer grass due to its association with Thitarodes (Hepialus) larvae. The extremities of habitat condition and endurance of fungus to sustain adversaries by production of metabolites has led to unique profile of metabolites including nucleosides, proteins and nitrogenous compounds, polysaccharides, sterols, fatty acids and their derivatives, as well as some vitamins and inorganics. There are wide ranges of biological activities that have been reported from O. sinensis including anti-inflammatory, antioxidant, anti-tumor, anti-metastatic, immunomodulatory, antimicrobial, insecticidal, hypolipidaemic, hypoglycemic, antiageing, lipolytic, neuroprotective, renoprotective effects, etc. Although several components can be responsible for activity of compounds, understanding ultimate compounds which fit with biomolecular target is crucial to combat diseases and development of new class of effective drugs. In this review a concise evaluation of pharmacological activities of metabolites reported for O. sinensis are done to provide insight into its biologically active components.

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“…It is also used in treatment of immune disorders and as an adjunct to modern cancer therapies (chemotherapy, radiation treatment, and surgery). Ophiocordyceps sinensis is believed, particularly in and around Tibet, to be a remedy for weakness and fatigue, and is often used as an overall rejuvenator for increased energy while recovering from serious illness [2]- [4].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on Chemical Composition and Pharmacological Effects of <i>Paecilomyces hepiali</i> and Wild <i>Ophiocordyceps sinensis</i>

Chioza¹,

Ohga

2014

AiM

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This study looked at comparison of chemical components and pharmacological activity between wild Ophiocordyceps sinensis and Paecilomyces hepiali. The chemical components investigated included amino acids, vitamins, dietary elements, protein, lipid, ash, carbohydrates, crude fibre, ergosterol and mannitol. Studies on pharmacological activity included anti-platelet aggregation, inhibitory effect on IL-8 gene expression, anti-mutagenic activity, skin whitening effect and improvement activity on human skin texture. The results show that P. hepiali has a larger total content of seven essential amino acids (leucine, lysine, methionine, phenylalanine, tryptophan, tyrosine and valine) than O. sinensis, 8580 mg/100g and 6180 mg/100g respectively. The total content of dietary elements analysed (potassium, magnesium, zinc, copper, manganese and selenium) was also higher in P. hepiali (3135 mg/100g) than that in O. sinensis (2445 mg/100g). The total content of four vitamins (B1, B2, B6 and E) was almost equal for both fungi. Paecilomyces hepiali had more content of protein, lipid, ash, carbohydrate, ergosterol and mannitol than O. sinensis. However, the contents of lipid and ash were not significantly different between the two fungi. The hot water extract of P. hepiali has been shown to have a number of pharmacological effects which include 1) inhibition of aggregation on human platelet, 2) inhibition of IL-8 gene expression, 3) anti-mutagenic activity, 4) inhibition effect on production of melanin, and 5) improvement on human skin texture. Anti-platelet aggregation effects on human platelet, inhibition of IL-8 gene expression, anti-mutagenic activity and improvement effect on human skin texture were greater in P. hepiali treatments than that in wild O. sinensis.

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Cordyceps

Cited by 8 publications

References 8 publications

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir

A Comparative Study on Chemical Composition and Pharmacological Effects of <i>Paecilomyces hepiali</i> and Wild <i>Ophiocordyceps sinensis</i>

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Cordyceps

Cited by 8 publications

References 8 publications

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Review on Pharmacologically Active Metabolites from Yarsagumba (Ophiocordyceps sinensis), an Epitome of Himalayan Elixir

A Comparative Study on Chemical Composition and Pharmacological Effects of &lt;i&gt;Paecilomyces hepiali&lt;/i&gt; and Wild &lt;i&gt;Ophiocordyceps sinensis&lt;/i&gt;

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A Comparative Study on Chemical Composition and Pharmacological Effects of <i>Paecilomyces hepiali</i> and Wild <i>Ophiocordyceps sinensis</i>