Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota

Song, Lanyue; Yang, Jintao; Kong, Weihan; Liu, Yang; Liu, Shuyan; Su, Ling

doi:10.1016/j.ijbiomac.2023.124333

Cited by 11 publications

(3 citation statements)

References 99 publications

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“…An α-pyranose with a molecular weight of 15.94 kDa, separated and purified from Cordyceps militaris, was reported to have anti-allergic asthma effects. The potential mechanisms may be related to improving inflammatory cytokine levels, ameliorating the histopathological damages in the lung and intestinal tissues, regulating the oxidative and inflammatory pathways, reversing gut dysbiosis and improving microbiota function in allergic asthma model animals [128]. Huang et al [129] investigated the promising ability to protect mice from obesity of Cordyceps militaris polysaccharides.…”

Section: Other Activitiesmentioning

confidence: 99%

A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Bai,

Su,

Zhang

et al. 2023

Molecules

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Traditional Chinese medicine (TCM) is a class of natural drugs with multiple components and significant therapeutic effects through multiple targets. It also originates from a wide range of sources containing plants, animals and minerals, and among them, plant-based Chinese medicine also includes fungi. Fungal traditional Chinese medicine is a medicinal resource with a long history and widespread application in China. Accumulating evidence confirms that polysaccharide is the main pharmacodynamic material on which fungal TCM is based. The purpose of the current systematic review is to summarize the extraction, isolation, structural identification, biological functions, quality control and medicinal and edible applications of polysaccharides from fungal TCM in the past three years. This paper will supplement and deepen the understanding and application of polysaccharides from fungal TCM, and propose some valuable insights for further research and development of drugs and functional foods.

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Section: Other Activitiesmentioning

confidence: 99%

A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Bai,

Su,

Zhang

et al. 2023

Molecules

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“…13 Although relatively new to people, Alistipes played a crucial role in the regulatory effect of Cordyceps militaris polysaccharide on allergic asthma, showing a positive relationship with interferon-γ (IFN-γ) and a negative correlation with IgE and interleukin-4 (IL-4). 14 These studies demonstrated that intestinal flora are connected to pulmonary inflammation, thereby highlighting potential therapeutic treatments for asthma by targeting the gut microbiota.…”

Section: Introductionmentioning

confidence: 99%

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Guo,

Shi,

et al. 2023

Food Funct.

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“…While corticosteroids, long-acting beta agonists, and montelukast can mitigate airway inflammation and relieve bronchospasm, they cannot cure asthma; symptoms often recur upon treatment cessation [16]. Moreover, dexamethasone (DEX), used to treat inflammatory diseases, including asthma, commonly causes gastrointestinal discomfort such as nausea and abdominal pain [17]. Thus, there is an urgent need for effective and safe alternative treatments for allergic asthma.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice

Wang,

He,

Dang

et al. 2024

Foods

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Asthma is a prevalent respiratory disease. The present study is designed to determine whether gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in ovalbumin (OVA)-induced mice and explore the effect and potential mechanism therein. Asthma model mice were constructed by OVA treatment, and kynurenine (KYN), indole-3-lactic acid (ILA), in-dole-3-carbaldehyde (I3C), and indole acetic acid (IAA) were administered by intraperitoneal injection. The percent survival, weight and asthma symptom score of mice were recorded. The total immunoglobulin E and OVA-specific (s)IgE in the serum and the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) were detected by the corresponding ELISA kits. The composition of the gut microbiota and tryptophan-targeted metabolism in mouse feces were analyzed using 16S rRNA gene sequencing and targeted metabolomics, respectively. The four tryptophan metabolites improved the percent survival, weight and asthma symptoms of mice, and reduced the inflammatory cells in lung tissues, especially I3C. I3C and IAA significantly (p < 0.05) downregulated the levels of OVA-IgE and inflammatory cytokines. KYN was observed to help restore gut microbiota diversity. Additionally, I3C, KYN, and ILA increased the relative abundance of Anaeroplasma, Akkermansia, and Ruminococcus_1, respectively, which were connected with tryptophan metabolic pathways. IAA also enhanced capability of tryptophan metabolism by the gut microbiota, restoring tryptophan metabolism and increasing production of other tryptophan metabolites. These findings suggest that tryptophan metabolites may modulate asthma through the gut microbiota, offering potential benefits for clinical asthma management.

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Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota

Cited by 11 publications

References 99 publications

A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Liubao tea extract ameliorates ovalbumin-induced allergic asthma by regulating gut microbiota in mice

Gut Microbiota-Derived Tryptophan Metabolites Alleviate Allergic Asthma Inflammation in Ovalbumin-Induced Mice

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