Cordyceps fungi: natural products, pharmacological functions and developmental products

Zhou, Xuan‐Wei; Gong, Zhenghua; Su, Ying; Lin, Juan; Tang, Kexuan

doi:10.1211/jpp.61.03.0002

Cited by 297 publications

(145 citation statements)

References 46 publications

(38 reference statements)

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“…This way, the results obtained are similar to those reached by other research groups (Zhou et al, 2009). Unsaturated fatty acids are effective physiologically active components, which decrease blood lipids and protect against cardiovascular disease (Zhou et al, 2009).…”

Section: Resultssupporting

confidence: 88%

“…Zhou et al (2009) stated that unsaturated fatty acids content reaches 57.84% in Cordyceps species, the linoleic acid content being the highest one, followed by oleic acid. The saturated fatty acids content was 42.16%, palmitic and octadecanoic acids content being the highest.…”

Section: Resultsmentioning

confidence: 99%

“…Unsaturated fatty acids are effective physiologically active components, which decrease blood lipids and protect against cardiovascular disease (Zhou et al, 2009). Therefore, C. militaris proved to be a source of the so called "good fat".…”

Section: Resultsmentioning

confidence: 99%

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The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties

Reis

Barros

Calhelha

et al. 2013

Food and Chemical Toxicology

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Being Cordyceps militaris (L.) Link recognized as a medicinal and edible mushroom, this work intends to reveal new interesting bioactive molecules that could be isolated from this species. Hydrophilic and lipophilic compounds were analysed by chromatographic techniques coupled to different detectors. The methanolic extract of C. militaris was tested for its antioxidant, antibacterial, antifungal and anti-proliferative properties in different human tumor cell lines. Mannitol (2.01 g/100 g dw) and trehalose (24.71 g/100 g) were the free sugars found in C. militaris. Polyunsaturated fatty acids (68.87%) predominated over saturated fatty acids (23.40%) and δ-tocopherol was the only isoform of vitamin E detected (55.86 µg/100 g). The organic acids found in this mushroom were oxalic, citric and fumaric acids (0.33, 7.97 and 0.13 g/100g, respectively). p-Hydroxybenzoic acid was the only phenolic acid quantified in this species (0.02 mg/100 g); although cinnamic acid was also found (0.11 mg/100 g). The methanolic extract of C. militaris proved to inhibit lipid peroxidation, have reducing power and scavenge free radicals. This extract also revealed strong antibacterial and antifungal properties. Finally, the C. militaris extract was able to inhibit the proliferation of MCF-7 (breast), NCI-H460 (non-small lung), HCT-15 (colon) and HeLa (cervical) human carcinoma cell lines.

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Section: Resultssupporting

confidence: 88%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties

Reis

Barros

Calhelha

et al. 2013

Food and Chemical Toxicology

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show abstract

“…[7,8,12,14,15,24,39,48,52,66,67,83,92,98,107,121,136,140,161,162,167,173,177,178,180,188,194,200,207,208,[210][211][212]. [164].…”

Section: 배지 균사체 및 자실체 생산mentioning

confidence: 99%

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Lee¹,

Kim²,

Park³

et al. 2017

Journal of Life Science

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Cordyceps is a traditional Chinese medicinal herb well-known in China, Korea and Japan since B.C. 2,000. The original entomopathogenic fungus, Cordyceps sinensis belonging to the genus Cordyceps could not be found inside Korean peninsula due to the absence of the host insect for the corresponding entomogenous fungus. The development of artificial production methods of Korean type Cordyceps using the silkworm Bombyx mori as in vivo culture medium for the the entomopathogenic fungus Paecilomyces tenuipes is the first, and wonderful occasion in the research history of insect industry of this global world. The aim of this article is to review the historical research background, mass-production methods, and pharmacological effects of the silkworm-dongchunghacho (Paecilomyces tenuipes) which is a newly developed Korean medicinal insect-borne mushroom, and another non-insect-borne medicinal mushroom (Cordyceps militaris and Cordyceps pruinosa). Their biological actions include anti-tumor, immunostimulating, anti-fatigue, anti-stress, anti-oxidant, anti-aging, anti-diabetic, anti-inflammatory, anti-thrombosis, hypolipidaemic and insecticidal effects. The bioactive principles are protein-bound polysaccharides (hexose, hexosamin), cordycepin, D-manitol, acidic polysaccharide etc. Protein-bound polysaccharides and n-butanol fractions were demonstrated to show a significant anti-tumor activities but did not show a cytotoxicities. D-mannitol exhibited a significant prolongation of the life span in tumor bearing mice. Ergosterol did not show an efficient anti-tumor activity, but showed a significant phagocytosis enhancing activity. Anti-tumor activity of silkworm-dongchunghacho might be attributed to immuno-stimulating activities rather than cytotoxic effects [164]. Also this review comprises the breeding of Dongchunghacho varieties, optimization of culture conditions, improvement of learning and memory by Dongchunghacho, application of them as foods and chemical constituents.

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“…Wei et al (2016) recently suggested that O. sinensis sexual state should entitle Chinese Cordyceps (Wei et al, 2016). In addition, Chinese Cordyceps holds a lot of bioactive components, such as nucleosides, Cordyceps polysaccharides, cordycepic acid, ergosterol and etc., which had a series of unique efficacy on inhibiting tumor growth, anticancer, control high blood sugar (Lo et al, 2006;Zhou et al, 2009a), significantly improving the immune function of the human body and other unique effects (Paterson, 2008;Zhang et al, 2009). However, its medicinal value, the effect of prevention and treatment disease, as well as the role played in the local economy, has been widely studied and recognized in the world (Zhang et al, 2009;Weckerle et al, 2010;Winkler, 2010).…”

Section: Introductionmentioning

confidence: 99%

Identification and Bioactive Potential of Endogenetic Fungi Isolated from Medicinal Caterpillar Fungus Ophiocordyceps sinensis from Tibetan Plateau

Guo¹,

Liu²,

Gao³

et al. 2017

IJAB

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To characterize and explore the endogenetic fungi of Chinese Cordyceps from Tibetan plateau for their bioactive potential, more than 30 kinds of endogenetic fungi were routinely isolated from Chinese Cordyceps. Six selected isolates were further investigated on the mycelial growth rate, morphology and molecular characteristics and the content of nucleosides in the mycelial fermentation products. The results showed that all the six strains could grow well in the ordinary media. Analysis of their molecular and morphological characteristics confirmed that the six strains belonged to the genus of Fusarium, Mucor and Mortierella, respectively. The nucleosides including uridine, guanosine, adenosine and cordycepin had been detected in the mycelial fermentation products of all the 6 strains. The strain NS2-B1 was the best one in all strains, and could produce the most nucleosides with a yield of 1284.47±26.05 μg/g. Meanwhile the strain NS2-B1 could produce more adenosine and cordycepin (418.72±2.38 μg/g and 179.14±0.57 μg/g), which was significantly higher than that of Chinese Cordyceps (18.47±0.31 μg/g and 90.43±1.46 μg/g; p<0.01). This study proved that the selected strain NS2-B1 had a potential application value.

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Cordyceps fungi: natural products, pharmacological functions and developmental products

Abstract: Recent research advances in the study of Cordyceps, including Cordyceps mushrooms, chemical components, pharmacological functions and developmental products, has been reviewed and discussed. Developing trends in the field have also been appraised.

Cited by 297 publications

References 46 publications

The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties

The methanolic extract of Cordyceps militaris (L.) Link fruiting body shows antioxidant, antibacterial, antifungal and antihuman tumor cell lines properties

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Identification and Bioactive Potential of Endogenetic Fungi Isolated from Medicinal Caterpillar Fungus Ophiocordyceps sinensis from Tibetan Plateau

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