Cordycepin: A bioactive metabolite with therapeutic potential

Tuli, Hardeep Singh; Sharma, Anil Kumar; Sandhu, Sardul Singh; Kashyap, Dharambir

doi:10.1016/j.lfs.2013.09.030

Cited by 254 publications

(159 citation statements)

References 51 publications

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“…Cordycepin, also termed 3'-deoxyadenosine, originates from Ophiocordyceps sinensis, which is commonly used in Traditional Chinese Medicine (15). Cordycepin is an adenosine analogue that differs from adenosine by the deletion of oxygen in the 3' position of the ribose region (16). Therefore, certain enzymes are unable to discriminate between the two.…”

Section: Cordycepin Induces Apoptosis and Autophagy In Human Neuroblamentioning

confidence: 99%

“…Therefore, certain enzymes are unable to discriminate between the two. Cordycepin may be phosphorylated to mono-, di-and triphosphate forms within cells, and participates in a number of biochemical reactions (16). For example, triphosphate cordycepin may be incorporated into RNA molecules, leading to the premature termination of RNA synthesis and inhibition of transcription elongation (17).…”

Section: Cordycepin Induces Apoptosis and Autophagy In Human Neuroblamentioning

confidence: 99%

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Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells

Li¹,

Li²,

Zhu³

et al. 2015

Oncology Letters

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Abstract. Cordycepin, also termed 3'-deoxyadenosine, is a derivative of the nucleoside adenosine that represents a potential novel class of anticancer drugs targeting the 3' untranslated region of RNAs. Cordycepin has been reported to induce apoptosis in certain cancer cell lines, but the effects of cordycepin on human neuroblastoma cells have not been studied. In the present study, an MTT assay revealed that cordycepin inhibits the viability of neuroblastoma SK-N-SH and BE(2)-M17 cells in a dose-dependent manner. In addition, cordycepin increases the early-apoptotic cell population of SK-N-SH cells, as determined by fluorescence-activated cell sorting analysis. The induction of apoptosis in neuroblastoma cells by cordycepin was further confirmed by western blotting, which revealed cleavage of caspase-3 and poly(adenosine diphosphate-ribose) polymerase 1 in the SK-N-SH and BE(2)-M17 cells. Cordycepin also induced the formation of a punctate pattern of light-chain 3 (LC3)-associated green fluorescence in the SK-N-SH cells transfected with a pEGFP-LC3 vector. Furthermore, western blotting revealed cleavage of LC3 A/B in cordycepin-treated neuroblastoma SK-N-SH cells. Taken together, the results indicate that cordycepin significantly increases apoptosis and autophagy in neuroblastoma cells, and may therefore be a drug candidate for neuroblastoma therapy, but requires additional evaluation.

show abstract

Section: Cordycepin Induces Apoptosis and Autophagy In Human Neuroblamentioning

confidence: 99%

Section: Cordycepin Induces Apoptosis and Autophagy In Human Neuroblamentioning

confidence: 99%

Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells

Li¹,

Li²,

Zhu³

et al. 2015

Oncology Letters

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show abstract

“…In turn, C. militaris is known to demonstrate antiviral activity (Jiang et al, 2011). The medical potential of metabolites of C. militaris has been reviewed and discussed comprehensively in the past (Das et al, 2011;Tuli et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…At molecular level, cordycepin regulates the expression of cycloxygenase-2, inducible nitric oxide synthase and TNF-α (Kimet al, 2006). Therefore, when used as a food additive, it may affect the immune system in particular (Das et al, 2011;Tuli et al, 2013). The aim of this study was to evaluate the effects of CMF supplementation in feeds on the growth performance, immunocompetence and cytokine expression of weaned piglets.…”

Section: Introductionmentioning

confidence: 99%

Fermentation products of <i>Cordyceps militaris</i> enhance performance and modulate immune response of weaned piglets

Cheng¹,

Wen²,

Dybus³

et al. 2016

SA J. An. Sci.

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The aim of this study was to investigate the effect of supplementation of Cordyceps militaris fermentation products (CMF) on growth performance and immunocompetence of piglets. The study involved three groups of animals, which were supplemented with CMF (500, 1000 and 1500 μg/kg feed), and a control group. CMF supplementation significantly increased growth performance in weaned piglets. Bodyweight gain, average daily gain and feed intake in animals supplemented with 1000 µg CMF/kg feed were significantly higher in comparison with the control group. In addition, CMF supplementation only significantly increased the synthesis of Th1 cytokines, as indicated by the levels of IL-2 and IFN-γ. The piglets fed with the CMF supplement displayed an increased cellular immune response. Indeed, alveolar macrophages isolated from piglets supplemented with 1000 and 1500 µg CMF/kg feed had significantly higher chemotactic and phagocytic indices than those isolated from piglets that received the control feed or feed supplemented with 500 µg CMF/kg. In relation to the absence of effect on Th2 cytokines, the CMF supplement had no effect on hog cholera antibody titre. In summary, feed supplementation with CMF improves growth performance and enhances cell-mediated immunity. CMF supplementation may thus be useful at weaning to counteract physiological and immunological stress during this period. ______________________________________________________________________________________

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“…Several low toxic compounds are produced by entomopathogenic fungi Beauveria bassiana like destruxins, bassianolide, Beauvericin, efrapeptins, tenellin, oosporein [3][4][5]. The biometabolite beauvericin is first isolated from liquid fermented culture of Beaveria bassiana, which is a common and commercial entomopathogenic mycoinsecticide [6,7]. The genus Beauveria is well known mycoinsecticide and exhibits antimicrobial, antitumor, antifungal and antiviral activities [8].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

Sood¹,

S²,

Hu$^{³

et al. 2017

J Proteomics Bioinform

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An entomopathogenic fungus, Beauveria spp. has been known to have numerous pharmacological and therapeutic implications, especially, in terms of human health making it a suitable for ethnopharmacological use. Beauvericin is a cyclic hexadepsipeptide mycotoxin, a novel bio-metabolite derived from this fungus, exhibiting a very potent anticancer, cytotoxic activities, antiplatelet aggregation and antimicrobial activities. The current review discusses the therapeutic potential of beauvericin including pharmacological and biological activities which will certainly draw the attention of scientific community to improve the production of beauvericin for its use in medical fields.

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Cordycepin: A bioactive metabolite with therapeutic potential

Cited by 254 publications

References 51 publications

Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells

Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells

Fermentation products of <i>Cordyceps militaris</i> enhance performance and modulate immune response of weaned piglets

Pharmacological and Therapeutic Potential of Beauvericin: A Short Review

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