Cord Transferrin and Ferritin Values for Erythropoiesis in Newborn Infants of Diabetic Mothers.

Murata, K; Toyoda, Nagayasu; Ichio, T.; Ida, M.; Sugiyama, Yasuhiko

doi:10.1507/endocrj1954.36.827

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…IDM born to gestational, insulin-dependent and noninsulin-dependent diabetic mothers are at risk for low iron stores [8,46,50] . Sixty-five percent have ferritin concentrations !…”

Section: Factors That Determine Neonatal Ferritin Concentrationmentioning

confidence: 99%

“…Fetal hyperglycemia and hyperinsulinemia during gestations complicated by maternal diabetes mellitus increases fetal metabolic rate and oxygen consumption and result in fetal hypoxemia [51,52] . The abnormal iron indices in IDM are due to increased fetal iron utilization for erythropoiesis [46,50] . The degree of iron abnormality at birth correlates with elevated fetal erythropoietin and fetal glycosylated Hgb concentrations [46] .…”

Section: Factors That Determine Neonatal Ferritin Concentrationmentioning

confidence: 99%

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The Assessment of Newborn Iron Stores at Birth: A Review of the Literature and Standards for Ferritin Concentrations

et al. 2007

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Background: Serum ferritin measurements are used in clinical populations to estimate total body iron stores and the risk of subsequent iron deficiency or overload. The lack of normative newborn serum ferritin concentration data between 23 and 41 weeks has led to difficulty in establishing the incidence and degree of abnormal iron status in the neonatal period. Objectives: The primary objective of this review was to summarize the maternal and gestational factors that determine ferritin concentrations in full-term and pre-term newborn infants and to generate comprehensive reference values. The secondary objective was to assess serum ferritin concentrations in newborn infants at risk for abnormal fetal iron metabolism, including maternal diabetes mellitus, intrauterine growth restriction and maternal smoking during pregnancy. Methods: Serum ferritin and gestational age data at birth from 457 low-risk pre-term and term infants of 23–41 weeks gestation obtained from 35 published studies reviewed from a period of 25 years and from recently collected data from our centers were assessed by regression analysis. Slopes and intercepts of the high-risk groups were compared with the standard curve. Results: Umbilical cord serum ferritin concentrations increased with advancing gestational age, from a mean of 63 µg/l at 23 weeks to 171 µg/l at 41 weeks gestation (p < 0.001). The infants of diabetic mothers had a lower intercept than the control infants (p < 0.001). Conclusions: Iron deficiency and overload have been implicated in neurodevelopmental impairments. Normative cord serum ferritin data may permit a more precise assessment of infants who are at risk for abnormal iron status at birth.

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“…IDM born to gestational, insulin-dependent and noninsulin-dependent diabetic mothers are at risk for low iron stores [8,46,50] . Sixty-five percent have ferritin concentrations !…”

Section: Factors That Determine Neonatal Ferritin Concentrationmentioning

confidence: 99%

Section: Factors That Determine Neonatal Ferritin Concentrationmentioning

confidence: 99%

The Assessment of Newborn Iron Stores at Birth: A Review of the Literature and Standards for Ferritin Concentrations

et al. 2007

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“…Pregnancy complications characterised by uteroplacental vascular insufficiency and/or chronic hypoxia, such as that caused by gestational diabetes mellitus, hypertension and pre‐eclampsia, can also impact neonatal iron status. In response to hypoxia, iron is drawn from hepatic storage pools to support increased erythropoiesis, resulting in reduced ferritin concentrations and increased transferrin and transferrin receptor concentrations in infants born to mothers with such conditions (Chockalingam et al ; Murata et al ; Verner et al ). The iron status of infants born to mothers with gestational diabetes mellitus is further compounded if the infant is born macrosomic (Georgieff et al ; McLimore et al ).…”

Section: Risk Factors For Neonatal Iron Deficiencymentioning

confidence: 99%

The neonatal period: A missed opportunity for the prevention of iron deficiency and its associated neurological consequences?

McCarthy

Kiely

2019

Nutrition Bulletin

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Iron deficiency is the most common micronutrient deficiency worldwide. Iron is essential for the development of multiple organ systems, most especially the developing brain. Iron deficiency, particularly during sensitive periods of brain development, such as in early childhood, is associated with long‐lasting adverse consequences for cognition, motor function and behaviour. Little consideration has been given to iron deficiency in newborn infants and its potential health consequences. Fetal iron accretion is compromised by pregnancy complications such as pre‐term birth and gestational diabetes mellitus, and our work has identified an increased risk of low iron stores at birth from maternal lifestyle factors such as smoking and obesity. Early‐life events, including Caesarean section delivery, further add to the cumulative risk of neonatal iron deficiency, which can persist throughout infancy into early childhood. While investigations into the long‐term neurological consequences of neonatal iron deficiency are limited, there is evidence of poorer memory, motor function and language ability in children born iron deficient. Recently, we also identified significant behavioural consequences of neonatal deficiency persisting from 2 to 5 years of age, with effects particularly apparent in ‘high‐risk’ children born to obese or smoking mothers or delivered by Caesarean section. Interventions targeting the fetal/neonatal period could therefore represent a key opportunity for the prevention of iron deficiency and its associated long‐term health consequences. A dual approach is required, comprising public health strategies targeting prevention, to improve health in women of reproductive age, and the development of screening strategies for the early detection of iron deficiency in newborn infants.

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“…Maternal diyabetin fetal demir durumuna etkisini saptamak için yapılan çalışmalarda, kontrol grubuna oranla diyabetli anne bebeklerinde kordon kanında serum ferritin düzeyi anlamlı olarak düşük saptanmıştır (8)(9)(10). Ayrıca maternal diyabetin kronik intrauterin hipoksi ve plesantal vasküler yetmezliğe yol açarak eritropoezde artışa ve demir depolarının azalmasına neden olduğu ileri sürülmüştür (9).…”

Section: Introductionunclassified

Is it possible cord blood ferritin levels an early indicator of iron deficiency in newborns who have delivered complicated pregnancies?

Güzoğlu¹,

Karaman²,

İpek³

et al. 2015

Turk J Bioch

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Amaç: Bu çalışmada amaç kronik fetal hipoksi ya da bozulmuş uteroplasental kan akımı riski olan yenidoğanlarda kordon kanında, hemoglobin, serum demir ve ferritin düzeylerinin incelenmesidir. Yöntem: Çalışmaya hastanemizde doğum yapan 72 gebe kadın ve onların yenidoğan bebekleri alındı. Bu olgular iki gruba ayrılarak incelendi. Grup 1 komplikasyonlu gebelik geçiren 24 gebe ve onların bebeklerinden oluştu. Preeklampsi, gestasyonel diyabet, intrauterin büyüme geriliği varlığı komplikasyonlu gebelik olarak kabul edildi. Grup 2 ise gebeliği boyunca komplikasyon görülmeyen, sağlıklı 48 gebe ve onların bebeklerinden oluştu. Her iki gruptan doğumdan hemen sonra kordon kanından hemoglobin, serum demir ve ferritin tayini için kan örneği alındı. Bulgular: Gruplar kord kanında ki hemoglobin, demir ve ferritin açısından karşılaştırıldığında, Grup 1'deki hemoglobin değerleri Grup 2'ye göre istatistiksel olarak anlamlı düzeyde yüksek iken demir ve ferritin düzeyleri anlamlı olarak düşük saptandı ( sırası ile p=0,007, p=0,01, p=0,01). Sonuç: Komplikasyonlu gebeliklerden doğan bebeklerde serum ferritin değerlerinin düşük saptanması, bu bebeklerde erken dönemde demir eksikliği anemisi olasılığını arttırmaktadır. Objective:The main objective of the study was to determine of cord blood hemoglobin, ferrous and ferritin levels in newborns who have risk of fetal hypoxia or uteroplacental insufficiency. Method: 72 pregnant women who delivered in our hospital and their newborns were included the study. All cases were divided into two groups. Group 1 was included 24 complicated pregnancies (preeclampsia, gestational diabetes and intrauterine growth retardation) and their newborns. Group 2 was included 48 healthy pregnant women and their newborns. Hemoglobin, serum ferrous level and serum ferritin level in cord blood were tested for two groups after delivery. Results: In Group 1, cord blood hemoglobin level was significantly higher while ferrous and ferritin levels were significantly lower than Group 2 ( respectively p=0.007, p=0.01, p=0.01). Conclusion: Ferritin level is determined lower in newborns who have delivered complicated pregnancies. It is also increase of possibility of iron deficiency anemia in these newborns early term.Anahtar Kelimeler: Kord kanı, ferritin, komplike gebelikler.Keywords: Cord blood, ferritin, complicated pregnancies. GirişDemir eksikliği ve buna bağlı anemi en sık süt çocukluğu döneminde görülür. Demir eksikliği anemisinin (DEA) en önemli nedeni diyetteki eksiklik ve hızlı büyümeye bağlı artan ihtiyaç olduğu düşünülmektedir. Öte yandan DEA doku hipoksisi ve enzimlerin yapısındaki demirin yetersizliği nedeniyle sinir sistemi fonksiyonlarının azalmasına sebep olduğu bilinmektedir. Sinir sisteminin gelişimi için önemli olan postnatal ilk iki yılda, DEA'li çocukların uyarılmış potansiyel incelemelerinde merkezi ileti zamanının uzamış olduğu gösterilmiştir (1). Serum ferritin düzeyi vücut demir depolarını yansıtır. Ancak ferritin bir akut faz reaktanı olduğundan ateş, enflamatuar hastalık, enfeksiyon ve d...

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Cord Transferrin and Ferritin Values for Erythropoiesis in Newborn Infants of Diabetic Mothers.

Cited by 8 publications

References 6 publications

The Assessment of Newborn Iron Stores at Birth: A Review of the Literature and Standards for Ferritin Concentrations

The Assessment of Newborn Iron Stores at Birth: A Review of the Literature and Standards for Ferritin Concentrations

The neonatal period: A missed opportunity for the prevention of iron deficiency and its associated neurological consequences?

Is it possible cord blood ferritin levels an early indicator of iron deficiency in newborns who have delivered complicated pregnancies?

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