Cord Topographical Anatomy and its Role in Evaluating Intramedullary Lesions

Spain, James Andrew; Cressman, Scott; Marin, Horia; Patel, Suresh; Corrigan, John; Griffith, Brent

doi:10.1067/j.cpradiol.2017.09.007

Cited by 4 publications

(2 citation statements)

References 52 publications

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“…Spinal cord atrophy can be seen in the chronic stage of disease 10. Copper deficiency myelopathy may have clinical and imaging characteristics similar to SCD from B 12 deficiency, but low serum copper and ceruloplasmin levels will rule out the diagnosis 5…”

Section: Discussionmentioning

confidence: 99%

“…Subacute combined degeneration (SCD) is the spinal cord manifestation of B 12 deficiency and is characterised by paraesthesia, weakness, stiffness, numbness or tingling of limbs, ataxia and impaired vibration sense due to by selective demyelination of dorsal and lateral columns of the spinal cord. Classically, an ‘inverted V’ orientation of MRI hyperintensity in the posterior spinal cord can be appreciated 5…”

Section: Introductionmentioning

confidence: 99%

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Subacute combined degeneration: a case of pernicious anaemia without haematological manifestations

et al. 2020

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Vitamin B12 deficiency can be caused by a diverse group of aetiologies. One of the less common of these is an autoimmune condition pernicious anaemia, so named after the most common physiological manifestation of B12 deficiency: anaemia. However, B12 is also necessary for nervous system function and its depletion can lead to dysfunction of the posterior columns of the spinal cord resulting in subacute combined degeneration (SCD). This disease, while debilitating in its acute phase, can usually be mostly if not fully reversed if caught early and treated appropriately. Early detection can prove challenging if there are no haematological manifestations of B12 deficiency and the only guidance is the high index of suspicion. We present a case of pernicious anaemia leading to SCD without any clinical or laboratory findings of anaemia in this report.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%