Cord serum immunoglobulin E as a risk factor for allergic symptoms and sensitization in children and young adults

Abstract

Early markers of atopic predisposition are needed for targeting allergy preventive measures to high‐risk infants. An elevated cord serum immunoglobulin E (CS‐IgE) level is considered a risk factor for subsequent allergy in childhood. However, the previous studies have not assessed the predictive value of CS‐IgE in a follow‐up extended to adulthood. We aimed at clarifying whether CS‐IgE is useful in predicting subsequent atopic manifestations up to age 20 yr. A cohort of 200 unselected, full‐term newborns were prospectively followed up from birth to age 20 yr. The CS‐IgE level was successfully measured in 190 subjects at birth. The subjects were re‐examined at ages of 5, 11 and 20 yr with assessment of the occurrence of allergic symptoms during the preceding year, skin prick testing and measurement of serum total IgE. An elevated CS‐IgE level was associated with allergic symptoms and skin prick test positivity at age 5 yr (p = 0.03 and 0.01), with allergic rhinoconjunctivitis at age 20 yr (p = 0.04) and with an elevated serum total IgE at ages of 11 and 20 yr (p = 0.02 and 0.01). The sensitivity of CS‐IgE, i.e. the probability of an elevated CS‐IgE in an infant who subsequently develops atopy, in predicting skin prick test‐verified atopy at ages of 5 and 20 yr was 50% and 26%, respectively. The combination of elevated CS‐IgE and positive family history of allergy was strongly associated with subsequent atopic manifestations. Nevertheless, it showed a reduced sensitivity as compared to CS‐IgE or family history of allergy. We conclude that an elevated CS‐IgE level predicts subsequent atopy up to age 20 yr.

High Cord Blood Levels of the T-Helper 2-Associated Chemokines CCL17 and CCL22 Precede Allergy Development During the First 6 Years of Life

“…However, the use of CB IgE as a predictor has been limited because of poor sensitivity (27)(28)(29). Although our findings need to be confirmed in a larger number of samples, CB CCL22 may possibly be an attractive candidate as a predictor of elevated IgE levels and future allergy development.…”

The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years

“…29,30 Indeed, the fetus has an ability to respond to its nutritional environment by altering gene expression and cell numbers, selecting clones of cells and thereby guiding body size and metabolism. 31 Rapid weight gain in early infancy may reflect on the one hand a genetic predisposition to overweight, which is a programming initiated during the fetal period, or the mode of infant feeding, that is, formula feeding rather than breastfeeding, 32 or the early introduction of solid foods; 33 this being not the case in the present population.…”

Diagnostic value of serum total IgE the primary marker of allergic diseases

“…То есть, даже при отсутствии кли-нических симптомов заболевания в целях профи-лактики на ранних этапах развития «атопического марша» необходимо проведение скринингового ис-следования, которое должно быть обязательным па-раметром диспансеризации у детей первых трех лет жизни. В процессе сенсибилизации специфические антитела класса Е появляются значительно позднее, как правило, после 4 лет [19]. В табл.…”

“…Итак, повышение суммарного количества IgE-антител обнаруживают при аллергопатологии (ато-пический дерматит, бронхиальная астма, аллергиче-ский ринит, ангионевротический отек, крапивница), при гельминтозах, и редко при различной патологии иммунной системы (гипер-IgE-синдром, миелома, бронхолегочный аспергиллез), в том числе и аутоим-мунной патологии, такой как ревматоидный артрит, системная красная волчанка, псориаз [16,19]. В табл.…”