Cord Blood Thyroxine and Thyroid Stimulating Hormone Screening for Congenital Hypothyroidism: How Useful Are They?

Background:The aim of the present study was to determine the effect of various perinatal factors on cord blood TSH among newborns in Isfahan, Iran.Materials and Methods:This was a descriptive–analytic cross sectional study which performed in Isfahan Iran. During a period of four months, since February to May 2012 a total number of 440 newborns delivered in Alzahra and Shahid beheshti hospitals were enrolled in the study. For all newborns one mL blood sample from umbilical vein was obtained by one of the project investigators and sent to laboratory for further examinations. Cord blood TSH and birth body weight (BBW), gestational age, history of gestational diabetes mellitus (GDM), apgar at one minute, apgar at five minute, newborn gender and the mother's age were documented. Differences considered statistically significant if P < 0.01.Results:440 newborns enrolled in the study, 221 (50.2%) were male and 219 (49.8%) were female. Among study parameters, method of delivery had statistically significant relation with cord blood TSH (P < 0.001), and other factors such as BBW, gestational age, GDM, apgar at one minute, apgar at five minute, newborn gender and the mother's age didn’t have statistically significant relationship with cord TSH level.Conclusion:In conclusion we deduce that the only factor that can affect cord blood TSH was method of delivery. Infant with vaginal delivery has higher TSH level in cord blood. Other factors that were evaluated in this study didn’t have any statistically significant relationship.

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“…[111213] Currently in some countries it has been chosen for the methods of choice in the screening program. [14]…”

Section: Introductionmentioning

confidence: 99%

Influence of perinatal factors on thyroid stimulating hormone level in cord blood

Armanian¹,

Hashemipour²,

Esnaashari

et al. 2013

Adv Biomed Res

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“…Currently used for primary CHT screening in Singapore. More recent study from Abu Dhabi with DELFIA reagents showed cord fT4 to be insensitive, cord TSH to be more sensitive but specificity poorer than DBS [11].…”

Section: Cord Blood Dbs Collected At a Few Days Of Agementioning

confidence: 98%

Suitable Specimen Types for Newborn Biochemical Screening-A Summary

Hall¹

2017

IJNS

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Newborn biochemical screening has been in place in many countries for over fifty years initially testing dried skin puncture whole blood spotted on collection paper (DBS) or urine for phenylalanine or phenylketones to identify phenylketonuria. Countries wishing to commence newborn screening need to consider which type of specimen will provide a satisfactory specimen and matrix for testing for disorders relevant to their population, is acceptable to parents and can be readily transported to the analytical or laboratory facility without significant degradation. Whilst DBSs have largely become the specimen of choice they may not be applicable to all cultures and infrastructures. The majority of disorders appropriate to be identified in the newborn period can be detected in DBSs taken shortly after birth. Some are also detectable in cord blood or urine, some are not. Most disorders have an ideal and often different time window of age for identification in relation to treatment for optimum outcome. When embarking on newborn screening for the first time or in expanding what is already in place, it is important that the disorders considered are evaluated against the Wilson and Jungner criteria for population screening. A brief overview of specimen types including urine, cord blood and DBSs with some of their advantages and limitations is provided in this review to assist in decision-making.

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“…In some countries, such as Finland and Malta, cord blood sampling is used for newborn screening testing according to early maternal and newborn discharge [12,13], but it has been evaluated that better results are obtained from samples collected by heel/hand prick at a later stage [14,15].…”

Section: Sample Collectionmentioning

confidence: 99%

Mass spectrometry in clinical chemistry: the case of newborn screening

Marca

2014

Journal of Pharmaceutical and Biomedical Analysis

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Keywords:Newborn screening LC-MS/MS Tandem mass spectrometry Inborn errors of metabolism Clinical chemistry a b s t r a c t Newborn screening (NBS) program is a complex and organized system consisting of family and personnel education, biochemical tests, confirmatory biochemical and genetic tests, diagnosis, therapy, and patient follow up. The program identifies treatable metabolic disorders possibly when asymptomatic by using dried blood spot (DBS). During the last 20 years tandem mass spectrometry (TMS) has become the leading technology in NBS programs demonstrating to be versatile, sensitive and specific. There is consistent evidence of benefits from NBS for many disorders detected by TMS as well as for congenital hypothyroidism, cystic fibrosis, congenital adrenal hyperplasia by immune-enzymatic methods.Real time PCR tests have more recently been proposed for the detection of some severe combined immunodeficiences (SCID) along with the use of TMS for ADA and PNP SCID; a first evaluation of their cost-benefit ratio is still ongoing. Avoiding false negative results by using specific biomarkers and reducing the false positive rate by using second tier tests, is fundamental for a successful NBS program. The fully integration of NBS and diagnostic laboratories with clinical service is crucial to have the best effectiveness in a comprehensive NBS system.

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Cord Blood Thyroxine and Thyroid Stimulating Hormone Screening for Congenital Hypothyroidism: How Useful Are They?

Abstract: Cord FT4 identifies only infants with severe CH. Cord TSH is more sensitive than cord FT4 screening. Capillary TSH dried blood spot testing on the 3rd-5th day is the most sensitive method.

Cited by 19 publications

References 21 publications

Influence of perinatal factors on thyroid stimulating hormone level in cord blood

Influence of perinatal factors on thyroid stimulating hormone level in cord blood

Suitable Specimen Types for Newborn Biochemical Screening-A Summary

Mass spectrometry in clinical chemistry: the case of newborn screening

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