Cord blood screening for haemoglobinopathies in northern Nigeria

Kulkarni, A. G.; Jekeme, S. D. N.

doi:10.1080/00034983.1986.11812064

Cited by 3 publications

(3 citation statements)

References 8 publications

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“…In fact, the Peuhl ethnic group, who are shepherds and come from the Sahel and marry among cousins for two reasons: a) in order not to disperse family property, and b) since they are nomads, each family group wants to remain united, therefore they move and travel together. On the contrary, the elevated incidence of 13 S in the Yorouba ethnic group ( 13 S 0.117 over 13 C 0.068) is probably due to their origin from Nigeria where the Hb S is prevalent on Hb C (Kulkarni and Jekeme 1986). Since Hb SS and Hb SC die at a very young age (Tattah and Ekere 1975), more children are born to compensate for their this loss, maintaeining the proportion between 13 S and 13 C in this ethnic groupniae.…”

Section: Discussionmentioning

confidence: 97%

Anthropological consideration on prevalence and fitness of β C and β S genotypes in Burkina Faso (a survey in the public schools)

Simporé¹,

Pignatelli²,

Melis

et al. 2002

Int. J. Anthropol.

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Anthropological consideration on prevalence and fitness of 13 C and J3 S genotypes in Burkina Faso (a survey in the public schools).We have studied To study the incidence of hemoglobinopathies (Hb C and Hb S) we have examined in 15,367 students, aged 11.4 +/-4.64 years (median 11; range 1-26), riving in Burkina Faso (12,019 were students of 23 public schools of Ouagadougou and 3348 students of 7 public schools situated in six villages about 12-35 Km from Ouagadougou). In all groups studied, [3 S and [3 C gene frequencies were age dependent there was an age dependency of the [3 S and [3 C gene frequencies, since the advantage of HbS carriers in a malarial region is prevalently expressed in the first years of rife. In fact, [3 C the gene frequency of 13 C increases, and the 13 S decreases with age. The Mossi, living prevalently mainly in Ouagadougou, show a gene frequency which is similar to the Bissa ethnic groups, where the C gene frequencies (0.116 and 0.118) wereare more higher than the S (0.049 and 0.044 respectively). On the contrary in the Peuhl ethnic group the 13 C and [3 S gene frequencies (0.049 and 0.049) were are the same, while in the Yoronba ethnic group immigrated from Nigeria a prevalence of [3 S gene frequency is higher (0.117) than over the [3 C (0.068)gene frequencies was found in the Yorouba ethnic group, who is immigrated from Nigeria, showing that different gene frequencies are found in different ethniae ethnic groupscorrespond to different gene frequencies.

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Section: Discussionmentioning

confidence: 97%

Anthropological consideration on prevalence and fitness of β C and β S genotypes in Burkina Faso (a survey in the public schools)

Simporé¹,

Pignatelli²,

Melis

et al. 2002

Int. J. Anthropol.

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show abstract

“…In fact, the Peuhl ethnic group, who are shepherds and come from the Sahel and marry among cousins for two reasons: a) in order not to disperse family property, and b) since they are nomads, each family group wants to remain united, therefore they move and travel together. On the contrary, the elevated incidence of 13 S in the Yorouba ethnic group (13 S 0.117 over 13 C 0.068) is probably due to their origin from Nigeria where the Hb S is prevalent on Hb C (Kulkarni and Jekeme 1986). Since Hb SS and Hb SC die at a very young age (Tattah and Ekere 1975), more children are born to compensate for this loss, mantaining the proportion between 13 S and 13 C in this ethnic group.…”

Section: Discussionmentioning

confidence: 97%

Anthropological consideration on prevalence and fitness of β C and β S genotypes in Burkina Faso (a survey in the public schools)

Simporé¹,

Pignatelli²,

Melis³

et al. 2002

Int. J. Anthropol.

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Objective: To study the incidence of hemoglobinopathies (Hb C and Hb S) we have examined 15,367 students, aged 11.4 +/-4.64 years (median 11; range 1-26), living in Burkina Faso (12,019 were students of 23 public schools of Ouagadougou and 3348 students of 7 public schools situated in six villages about 12-35 Km from Ouagadougou).Results: In all schools, we found a prevalence of females (54.2%) over males (45.8%) with a high incidence of Hb AC (19.16%), over Hb AS (8.35%). As expected, the gene frequency of B C in the schools of Ouagadougou was 0.112 +/-0.015 and of B S 0.049 +/-0.012, and this was similar in village schools (0.128 +/-0.010 and 0.049 +/-0.09 respectively), irrespective of town latitude. In all groups studied, 13 S and 13 C gene frequencies were age dependent since the advantage of HbS carriers in a malarial region is prevalently expressed in the first years of life. In fact, 13 C gene frequency increases, and 13 S decreases with age. The Mossi, living mainly in Ouagadougou, show a gene frequency which is similar to the Bissa ethnic groups, where the 13 C gene frequencies (0.116 and 0.118) are higher than the 13 S (0.049 and 0.044 respectively). On the contrary in the Peuhl ethhic group 13 C and 13 S gene frequencies (0.049 and 0.049) are the same, while in the Yorouba ethnic group immigrated from Nigeria 13 S gene frequency is higher (0,117) than the 13 C (0.068), showing that different genr frequencies are found in different ethnic groups. Conclusion: The difference in 13 S and 13 C genes frequencies (0.049 and 0.116) found in comparison with a previously performed study (Labie et al, 1984) in the same region (0.03 for the B S gene and 0.14 for the 13 C gene)~ may be due to migration flow of 13 S genes from the near Sahel region or to changes in life expectancy of children with 13 C and i~ S phenotypes. Moreover, the high percentage of SC (1,06%) and SS (0.188%) individuals detected with the present screening, compared with the lower percentages found by Labie et al in 1984, suggest that a modified environment can play an important role in reducing the morbility and lethality of 13 S genotype. HoweVer, even today the number of students affected by HbSC and lib SS attending the schools remains low. Stricter controls of correlated diseases are necessary to guarantee healthier life conditions. Anthropological consideration on prevalence fitness of B C and B S genotypes in Burkins Faso (a survey in the public schools) is a reprint of the publication published in the last issue

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“…Nigeria (Federal Republic of Nigeria) Although a cord blood screening pilot was initiated in Nigeria in 1986 (Kulkarni and Jekeme 1986), the first serious NBS pilot for SCD began with a study of 644 babies in one hospital in Benin City in 2000 (Odunvbun et al 2008). Laboratory testing was done in collaboration with the research laboratory at the National University of Benin.…”

Section: Morocco (Kingdom Of Morocco)mentioning

confidence: 99%

Empowering newborn screening programs in African countries through establishment of an international collaborative effort

et al. 2020

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In an effort to explore new knowledge and to develop meaningful collaborations for improving child health, the First Pan African Workshop on Newborn Screening was convened in June 2019 in Rabat, Morocco. Participants included an informal network of newborn screening stakeholders from across Africa and global experts in newborn screening and sickle cell disease. Over 150 attendees, representing 20 countries, were present including 11 African countries. The agenda focused on newborn screening rationale, techniques, system development, implementation barriers, ongoing research, and collaborations both globally and across Africa. We provide an overview of the workshop and a description of the newborn screening activities in the 11 African countries represented at the workshop, with a focus on sickle cell disease.

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Cord blood screening for haemoglobinopathies in northern Nigeria

Cited by 3 publications

References 8 publications

Anthropological consideration on prevalence and fitness of β C and β S genotypes in Burkina Faso (a survey in the public schools)

Anthropological consideration on prevalence and fitness of β C and β S genotypes in Burkina Faso (a survey in the public schools)

Anthropological consideration on prevalence and fitness of β C and β S genotypes in Burkina Faso (a survey in the public schools)

Empowering newborn screening programs in African countries through establishment of an international collaborative effort

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