Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes

Helguera-Repetto, Addy Cecilia; Villegas-Mota, Isabel; Arredondo-Pulido, Guadalupe Itzel; Cardona–Pérez, Jorge Arturo; León-Juárez, Moisés; Rivera-Rueda, María Antonieta; Arreola-Ramírez, Gabriela; Mateu-Rogell, Paloma; Acevedo‐Gallegos, Sandra; López-Navarrete, Gloria Elena; Valdespino-Vázquez, María Yolotzin; Martínez-Salazar, Guadalupe; Rodríguez-Bosch, Mario; Coronado-Zarco, I.A.; Castillo-Gutiérrez, María del Rosario; Cuevas-Jiménez, Carlos Alberto; Moreno-Verduzco, Elsa Romelia; Sosa, Salvador Espino Y; Cortés-Bonilla, Manuel; Irles, Claudine

doi:10.3389/fped.2022.883185

Cited by 8 publications

(4 citation statements)

References 38 publications

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“…It's well known that, immunglobuline G antibodies can be transferred from mother to baby. In a study conducted that 76% of neonates from seropositive mothers had antibodies against SARS-CoV-2 in cord blood, of whom 56% had a SARS-CoV-2 negative test result at birth (11). Although, a positive association between maternal IgG levels with neonatal IgG levels was observed in that study, the IgG level in this current baby was negative while the IgG level positive in the mother.…”

Section: Discussionmentioning

confidence: 69%

Gebelik ve Emzirme Dönemime Ait COVİD-19 Hikayem: Anne ve Yenidoğan Verileri

Yavaş

Yigit

Bırı³

2023

Türkiye Çocuk Hast Derg

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The novel type coronoviruses spreaded all around the world, and caused a global health problem around the world since 2019. The number of pregnant women infected by new type of coronoviruses have been on the rise. COVID-19 infection in pregnancy can be experienced with different symptoms as like asymptomatic infection, mild disease (no evidence of pneumonia or hypoxia), moderate disease (viral pneumonia), severe disease (severe pneumonia) or critical illness (acute respiratory distress syndrome, sepsis, septic shock, or complications such pulmonary embolism or acute coronary syndrome). Fortunately, most pregnant women infected with SARS-CoV-2 are asymptomatic, and most symptomatic women experience only mild or moderate cold/flu-like symptoms. The effect of these viruses on the fetus, virus transmission from mother to baby and the protective role of antibodies are not clear yet. Although, the majority of newborns were asymptomatic; tachypnea, most likely secondary to transient tachypnea observed as the most common symptom. On the other hand, late complications of the Coronovirus disease-19 can be presented in some organs and/or systems like heart, brain, lung, gastrointestinal system. Here described a case, whose got Coronovirus disease-19 during third trimester of the pregnancy with transient cardiac dysrhythmia after Coronovirus disease-19.

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Section: Discussionmentioning

confidence: 69%

Gebelik ve Emzirme Dönemime Ait COVİD-19 Hikayem: Anne ve Yenidoğan Verileri

Yavaş

Yigit

Bırı³

2023

Türkiye Çocuk Hast Derg

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“…One of the factors affecting the transplacental antibody transfer ratio is antibody concentrations in maternal blood since, in our study and in previous studies, correlation between maternal and cord blood antibody concentrations was demonstrated. [12][13][14][15][16]20,21 Moreover, previous studies demonstrated that compared with asymptomatic infections, symptomatic infections with SARS-CoV-2 were associated with higher maternal antibody concentrations. 13,14,20,21 In addition, the timing of the infection during the pregnancy affects the antibody transfer.…”

Section: Discussionmentioning

confidence: 99%

“…[12][13][14][15][16]20,21 Moreover, previous studies demonstrated that compared with asymptomatic infections, symptomatic infections with SARS-CoV-2 were associated with higher maternal antibody concentrations. 13,14,20,21 In addition, the timing of the infection during the pregnancy affects the antibody transfer.…”

Section: Discussionmentioning

confidence: 99%

Detection of SARS-CoV-2 Antibodies in Matched Pregnant Women and Newborn Blood

Haytoğlu

Haytoglu

Özlü

et al. 2023

J Pediatr Infect Dis

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Objective The factors affecting the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from mother to newborn and the duration of seropositivity rates in these infants have not yet been clearly demonstrated. The objectives of this study were (1) to assess the levels of SARS-CoV-2 spike–specific immunoglobulin G (IgG) in women infected in the pregnancy period and newborns born to these women and (2) to search the transplacental transfer ratio of spike-specific IgG. Methods Seventy pregnant women with symptomatic SARS-CoV-2 infection and their newborns were prospectively followed. Anti–SARS-CoV-2 immunoassay was used for the detection of the in vitro quantitative determination of total antibodies to the SARS-CoV-2 spike protein. Discussion Spike-specific IgG was demonstrated in 89.1% (44 of 46) of pregnant women infected more than 14 days before delivery and in 92.6% (43 of 44) of their newborns. Median transfer ratio of spike-specific Ig was 0.87 (interquartile range [IQR], 0.34–0.90), 1.0 (IQR, 0.9–0.29), and 0.81 (IQR, 0.02–1.0) in first trimester (n = 4), second trimester (n = 14), and third trimester (n = 28) pregnant women, respectively. Antibody transfer ratio was correlated with time elapsed from infection (p < 0.001). Peak antibody transfer ratio above 1 was observed at a median 60 to 120 days after the infection from delivery. Antibody transfer ratio was high in pregnant women infected more than 60 days before delivery (p < 0.001). Transfer ratio was significantly higher in the severe-critically symptomatic women (n = 15) than the mild-moderately symptomatic women (n = 55) (p = 0.001). At 3 months, 18 of 25 infants (72%) had spike-specific IgG. Conclusion Timing from infection to delivery and severity of maternal infection are critical in assessing the antibody generation and transport. Higher antibody transfer ratio can be detected in neonates when SARS-CoV-2 infection is present for more than 60 days before birth. Maternally derived antibody can persist for 3 months after birth.

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“…Several studies have explored the placental transfer of maternal SARS-CoV-2 specific antibodies following maternal infection, the largest cohort published to dateto our knowledge -evaluated 145 mothers [8][9][10][11][12][13][14][15][16]. There remains a need for more extensive studies to improve our understanding of the complex dynamics of placental transfer of IgG following natural SARS-CoV-2 infection, which may pave the way for advances in vaccination campaigns [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and placental transfer of SARS-CoV-2 antibodies in unvaccinated pregnant women

Vercoutere,

Zina,

Telis

et al. 2024

BMC Infect Dis

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Purpose Pregnant women are at risk of severe SARS-CoV-2 infection, potentially leading to obstetric and neonatal complications. Placental transfer of antibodies directed to SARS-CoV-2 may be protective against neonatal COVID-19, but this remains to be studied. We aimed to determine the seroprevalence of SARS-CoV-2 antibodies in a population of unvaccinated pregnant women and to determine the placental transfer of these antibodies. Methodology A total of 1197 unvaccinated women with mostly unknown pre-study SARS-CoV-2 infection status, were tested at delivery for SARS-CoV-2 spike protein IgG antibodies during the first year of the pandemic. Umbilical cord samples were collected and assessed for seropositivity if the mother was seropositive. Maternal characteristics, pregnancy and neonatal outcomes and data on SARS-CoV-2 infection were extracted from medical records. Results Specific IgG were detected in 258 women (21.6%). A significant placental transfer to the newborn was observed in 81.3% of cases. The earlier in the 2nd and 3rd trimesters that the mother had contracted the disease and the more symptomatic she was, the greater the likelihood of transplacental transfer of IgG to her newborn. Conclusion Approximately one in five women had detectable anti-SARS-CoV-2 spike protein IgG antibodies at delivery during the first year of the pandemic, and these antibodies were significantly transferred to their fetuses. This research provides further evidence to better understand the dynamics of the placental transfer of SARS-CoV-2 IgG antibodies from mothers to their newborns, which is necessary to improve vaccination strategies.

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Cord Blood SARS-CoV-2 IgG Antibodies and Their Association With Maternal Immunity and Neonatal Outcomes

Cited by 8 publications

References 38 publications

Gebelik ve Emzirme Dönemime Ait COVİD-19 Hikayem: Anne ve Yenidoğan Verileri

Gebelik ve Emzirme Dönemime Ait COVİD-19 Hikayem: Anne ve Yenidoğan Verileri

Detection of SARS-CoV-2 Antibodies in Matched Pregnant Women and Newborn Blood

Seroprevalence and placental transfer of SARS-CoV-2 antibodies in unvaccinated pregnant women

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