Cord blood retinol and retinol-binding protein in preterm and term neonates

Cardona-Pérez, Arturo; Valdés‐Ramos, Roxana; Topete-Lezama, Blanca; Meza-Camacho, Carlos; Udaeta-Mora, E

doi:10.1016/0271-5317(96)00002-4

Cited by 8 publications

(5 citation statements)

References 10 publications

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“…The geometric mean value of plasma retinol for fullterm Nigerian neonates in the present study was 0•57 mmol/l, which was low compared with a number of other studies: 0•84 mmol/l in the USA (Shenai et al 1981), 0•71 mmol/l in the UK (Chan et al 1993) and 0•74 mmol/l in Egypt (Hussein & Ali, 2000). Even greater values were reported by Basu et al (1994) and Cardonoparez et al (1996) for full-term neonates in Canada, namely 1•23 and 1•38 (range 0•70-2•50) mmol/l respectively; Godel et al (1996) postulated that values between 0•7 and 2•5 mmol/l represented a 'normal' range for newborn infants. However, this range appears to include some unusually high values, since the ranges of retinol concentrations reported by the other workers were similar to those reported by Chan et al (1993), namely 0•34-1•27 mmol/l.…”

Section: Discussioncontrasting

confidence: 81%

Use of biomarkers of sub-clinical infection, nutrition and neonatal maturity to interpret plasma retinol in Nigerian neonates

et al. 2003

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Using the World Health Organization criterion, the prevalence of sub-clinical vitamin A deficiency can be assessed using plasma retinol concentrations , 0·7 mmol/l. However, plasma retinol can be depressed by infection; thus, the use of this criterion alone may overestimate deficiency. In the present study, we investigated the usefulness of the acute-phase proteins (APP) a 1 -antichymotrypsin (ACT) and a 1 -acid glycoprotein (AGP), plasma carotenoids and anthropometric and gestational indices to interpret plasma retinol in the blood of 192 apparently healthy Nigerian neonates collected randomly during days 1 -20 postpartum. The mean weight (2·64 kg) and length (0·458 m) of the neonates and plasma concentrations (geometric mean, mmol/l) of retinol (0·54), a-carotene (0·072), ß-carotene (0·076) and lutein (0·080) were low. The prevalence of vitamin A deficiency was 72 %, indicating a severe public health problem. Babies who were of low birth weight (P, 0·003) or premature and low birth weight (P,0·023) had significantly lower retinol concentrations than full-term normal weight babies. Thirty-two neonates had abnormal ACT and forty-four abnormal AGP concentrations. Positive correlations between retinol and ACT (r 0·186, P¼0·05) and AGP (r 0·31, P¼0·0001) during days 1 -5 may be due to the increasing plasma retinol from maternal milk and a coincidental increasing capacity to synthesise APP. Subsequently, negative correlations between retinol and ACT (r 2 0·28, P¼ 0·02) and AGP (r 2 0·29, P¼0·018) from day 6 onwards reflected the continuing increase in plasma retinol, but no further increase in the APP. Overall, weight, ACT, lutein and age explained 30 % of the variance in retinol, but lutein was the most significant (r 2 0·18, P, 0·0001). Hence, the distribution of plasma retinol concentrations in this group of neonates was more strongly linked with nutrition (via the surrogate marker lutein) than infection.

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Section: Discussioncontrasting

confidence: 81%

Use of biomarkers of sub-clinical infection, nutrition and neonatal maturity to interpret plasma retinol in Nigerian neonates

et al. 2003

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“…The placenta is able to control vitamin A exchange between mother and fetus by releasing vitamin A to the fetus when maternal intake is deficient (33). Results in our study revealed that cord vitamin A level most likely was increased with gestational age, and this was consistent with a previous report that vitamin A accumulates in the fetus throughout the last third of pregnancy (34). Our findings clearly demonstrated that vitamin E levels in cord blood are lower than those in maternal blood as previously reported (28,29).…”

Section: Relationship Between Maternal and Cord Vitamins A E And Csupporting

confidence: 82%

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Wang

Ren

Liao

et al. 2009

J Nutr Sci Vitaminol

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Summary Background: Emerging evidence indicates that maternal oxidative stress during pregnancy could impair fetal growth and that antioxidant vitamins (e.g. vitamins A, E and C) have a significant role in miantaining physiological processes of pregnancy and growth. Aims: To determine the concentrations of vitamins A, E, and C in pair-matched maternal and cord serum samples of neonate, and thus to investigate the relationship between maternal serum levels of these vitamins at delivery and birth outcomes. Methods: A total of 143 mother-neonate pairs were recruited into the cross-sectional descriptive study. Demographic information was investigated by questionnaire. After delivery, both cord and maternal blood were collected for quantification of serum levels of vitamins A, E and C by HPLC. Results: Maternal serum levels of vitamins A and E were significantly higher than those in cord serum. In contrast, vitamin C level in cord serum was significantly higher than that in maternal serum. Further, we found that maternal vitamin A status was significantly correlated to both birth weight ( r ϭ 0.19, p ϭ 0.0419) and birth height ( r ϭ 0.21, p ϭ 0.0311), and these were manifested by these findings: (i) per 250.2 g reduction in birth weight concomitant with 1 mol/L increase in maternal serum vitamin A level ( p Ͻ 0.01; 95% CI: 56.9-451.5); and (ii) per 1% increase in the ratio of serum vitamin A level of neonate to mother concomitant with 0.8 cm increase in birth height ( p ϭ 0.049; 95% CI: 0.004-1.639). Conclusion: Maternal vitamin A, but not vitamins E and C, during pregnancy had a significant effect on birth outcomes. Further studies are necessary to investigate the role of these antioxidant vitamins in fetal growth at various gestation stages.

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“…Although serum retinol at 3-4 mo of age was significantly higher in infants of vitamin Aand ␤-carotene-supplemented mothers than in the control group, it remained low (< 0.70 mol/L) for > 60% and 75% of the 2 groups, respectively. These values are comparable with those of high-risk preterm newborns (25,34) and far lower than those of well-nourished, term neonates (28) or older infants elsewhere in Southern Asia whose mothers had received high-potency vitamin A soon after childbirth (35,36). It is possible that the maximal dose provided was too low to change the vitamin A status enough to affect survival (as suggested by the analysis among high compliers), that other factors limit the ability of vitamin A to promote survival of the fetus and young infant, or that the causes of early infant death are not responsive to maternal supplementation with vitamin A or ␤-carotene.…”

Section: Discussionsupporting

confidence: 71%

Maternal low-dose vitamin A or β-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal

Katz

West

Khatry

et al. 2000

The American Journal of Clinical Nutrition

107

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Background:The effect of vitamin A supplementation on the survival of infants aged < 6 mo is unclear. Because most infant deaths occur in the first few month of life, maternal supplementation may improve infant survival. Objectives: The objective was to assess the effect of maternal vitamin A or ␤-carotene supplementation on fetal loss and survival of infants < 6 mo of age. Design: Married women of reproductive age in 270 wards of Sarlahi district, Nepal, were eligible to participate. Wards were randomly assigned to have women receive weekly doses of 7000 g retinol equivalents as retinyl palmitate (vitamin A), 42 mg all-trans-␤-carotene, or placebo. Pregnancies were followed until miscarriage, stillbirth, maternal death, or live birth of one or more infants, who were followed through 24 wk of age. Results: A total of 43 559 women were enrolled; 15 832 contributed 17 373 pregnancies and 15 987 live born infants to the trial. The rate of fetal loss was 92.0/1000 pregnancies in the placebo group, comparable with rates in the vitamin A and ␤-carotene groups, which had relative risks of 1.06 (95% CI: 0.91, 1.25) and 1.03 (95% CI: 0.87, 1.19), respectively. The 24-wk mortality rate was 70.8/1000 live births in the placebo group, comparable with rates in the vitamin A and ␤-carotene groups, which had relative risks of 1.05 (95% CI: 0.87, 1.25) and 1.03 (95% CI: 0.86, 1.22), respectively. Conclusions: Small weekly doses of vitamin A or ␤-carotene given to women before conception, during pregnancy, and through 24 wk postpartum did not improve fetal or early infant survival in Nepal.Am J Clin Nutr 2000;71:1570-6.

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Cord blood retinol and retinol-binding protein in preterm and term neonates

Cited by 8 publications

References 10 publications

Use of biomarkers of sub-clinical infection, nutrition and neonatal maturity to interpret plasma retinol in Nigerian neonates

Use of biomarkers of sub-clinical infection, nutrition and neonatal maturity to interpret plasma retinol in Nigerian neonates

Concentrations of Antioxidant Vitamins in Maternal and Cord Serum and Their Effect on Birth Outcomes

Maternal low-dose vitamin A or β-carotene supplementation has no effect on fetal loss and early infant mortality: a randomized cluster trial in Nepal

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