Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia

Kadakia, Rachel; Scholtens, Denise M.; Rouleau, Gerald W.; Talbot, Octavious; George, Tabitha; Josefson, Jami L.

doi:10.1016/j.jpeds.2018.07.056

Cited by 28 publications

(32 citation statements)

References 26 publications

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“…[78][79][80][81][82] Most recently, metabolomics was used to identify specific metabolites that were predictive of women's eventual development of preeclampsia 83,84 and of their neonate's level of adiposity. 85 Metabolomics is also useful for understanding labor processes. Several teams of investigators differentiated between women in different phases of labor using metabolomics.…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index

Carlson

Frediani

Corwin

et al. 2020

AJP Rep

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Objectives The purpose of this study was to evaluate the metabolic pathways activated in the serum of African-American women during late pregnancy that predicted term labor dystocia. Study Design Matched case–control study (n = 97; 48 cases of term labor dystocia and 49 normal labor progression controls) with selection based on body mass index (BMI) at hospital admission and maternal age. Late pregnancy serum samples were analyzed using ultra-high-resolution metabolomics. Differentially expressed metabolic features and pathways between cases experiencing term labor dystocia and normal labor controls were evaluated in the total sample, among women who were obese at the time of labor (BMI ≥ 30 kg/m2), and among women who were not obese. Results Labor dystocia was predicted by different metabolic pathways in late pregnancy serum among obese (androgen/estrogen biosynthesis) versus nonobese African-American women (fatty acid activation, steroid hormone biosynthesis, bile acid biosynthesis, glycosphingolipid metabolism). After adjusting for maternal BMI and age in the total sample, labor dystocia was predicted by tryptophan metabolic pathways in addition to C21 steroid hormone, glycosphingolipid, and androgen/estrogen metabolism. Conclusion Metabolic pathways consistent with lipotoxicity, steroid hormone production, and tryptophan metabolism in late pregnancy serum were significantly associated with term labor dystocia in African-American women.

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Section: Discussionmentioning

confidence: 99%

Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index

Carlson

Frediani

Corwin

et al. 2020

AJP Rep

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“…Several studies have looked at the metabolic signature of diabetes in infants born to mothers with diabetes in pregnancy [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. However, these studies utilized cord blood collected at birth, which may not reflect neonatal metabolism that is independent of maternal/placental influences for some analytes.…”

Section: Available Literature On Diabetes and Newborn Screeningmentioning

confidence: 99%

“…Lower levels of phospholipids (phosphatidylcholine) were a consistent finding in studies of cord blood of infants who developed type 1 diabetes [ 3 , 4 , 5 , 6 , 7 ]. The metabolic perturbations in the cord blood of infants born to women with GDM varied among ethnicities, with derangement in BCAA (Branched Chain Amino Acids) and intermediates the most common affected networks [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Studies Using Cord Blood In Diabetes Research Evaluating mentioning

confidence: 99%

“…Analytes routinely tested for in newborn screening (NBS) for IEM, 48–72 h after birth, include many of the metabolites involved in these metabolic pathways. Some of the analytes tested for in NBS are deranged in diabetes overall [ 3 , 4 , 5 , 6 , 7 ] and diabetes in pregnancy [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]; however, these studies utilized cord blood ( Table 1 ). Cord blood as a sample for neonatal metabolic derangements has been shown to give false-negative results for amino acid and lipid disorders and for diagnosing maternal IEM in leucine, carnitine and vitamin-dependent pathways [ 16 , 17 , 18 ], reflecting placental/maternal metabolism for some analytes.…”

Section: Introductionmentioning

confidence: 99%

“…Residual deidentified dried blood spots (DBS) derived from routine NBS form a biobank and have been used in a few diabetes studies (mostly from Europe) and have given insight into the disease pathophysiology. Recent exciting publications from the Hyperglycemia and Adverse Pregnancy Outcomes study (HAPO), using cord blood [ 11 , 15 ], have highlighted the potential importance of intermediate metabolites in the pathophysiology of diabetes. The question arises how much of this pattern is neonatal and whether similar analyses using NBS could provide additional insights.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Newborn Screening Samples for Diabetes Research: An Underused Resource

Estrella

Wiley

Simmons

2020

Cells

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Inborn errors of metabolism and diabetes share common derangements in analytes of metabolic networks that are tested for in newborn screening, usually performed 48–72 h after birth. There is limited research examining the metabolic imprint of diabetes on newborn screening results. This paper aims to demonstrate the links between diabetes, biochemical genetics and newborn screening in investigating disease pathophysiology in diabetes, provide possible reasons for the lack of research in diabetes in newborn screening and offer recommendations on potential research areas. We performed a systematic search of the available literature from 1 April 1998 to 31 December 2018 involving newborn screening and diabetes using OVID, MEDLINE, Cochrane and the PROSPERO register, utilizing a modified extraction tool adapted from Cochrane. Eight studies were included after screening 1312 records. Five studies reanalyzed dried blood spots (DBS) on filter paper cards, and three studies utilized pre-existing results. The results of these studies and how they relate to cord blood studies, the use of cord blood versus newborn screening dried blood spots as a sample and considerations on newborn screening and diabetes research is further discussed. The timing of sampling of newborn screening allows insight into neonatal physiology in a catabolic state with minimal maternal and placental influence. This, combined with the wide coverage of newborn screening worldwide, may aid in our understanding of the origins of diabetes.

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Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence

Cao

Zhao

Hong

et al. 2020

Journal of Bone and Mineral Research

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Although the maternal intrauterine metabolic environment has been recognized to have a profound impact on fetal growth and development with lifelong health implications, to our knowledge, there have been few large‐scale birth cohort studies linking the cord metabolome (reflecting both the maternal and fetal metabolic state) with postnatal height measurements across the pediatric age range. Using data from the Boston Birth Cohort, an ongoing prospective birth cohort, this study investigated the association of cord plasma metabolites with children's height from birth to adolescence. Height was analyzed as attained height and longitudinal trajectories. Distinctive cord metabolite types were associated with attained height at different developmental windows: triacylglycerols [TAGs], diacylglycerols [DAGs], cholesterol ester [CEs], phospholipids, amino acids [AAs], acylcarnitines [ACs], and nucleotides in early (age 0–4 years) and middle (age 6–12 years) childhood; various metabolite types other than TAGs in later childhood (after age 14 years). Functional principal component analysis on children's repeated height measurements summarized two typical height trajectory components: loadings on first eigenfunction [FPC1] representing overall height by age, and loadings on second eigenfunction [FPC2] representing speed of pubertal height growth. Although only one cord metabolite was correlated with FPC1 after accounting for multiple testing, the study found 27 metabolites with significant overall effect on FPC2 among females and 18 among males. These metabolites were mostly phospholipids (including phosphatidylethanolamines [PEs], phosphatidylethanolamine plasmalogens [PE_Ps], phosphatidylcholines [PCs], lysophosphatidylethanolamines [LPEs], and lysophosphatidylcholines [LPCs]), AAs, and nucleotides. Their associations with height differed between overweight/obesity (OWO) and non‐OWO children, especially among females. In this prospective study of US understudied urban, low‐income, racially diverse children, we demonstrated that cord plasma metabolites were significantly associated with postnatal attained height at different age windows as well as height trajectories from birth to adolescence. We also revealed how these associations differed by children's sex and OWO status. Our findings help elucidate metabolic pathways underlying fetal origins of height growth across developmental stages. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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Cord Blood Metabolites Associated with Newborn Adiposity and Hyperinsulinemia

Cited by 28 publications

References 26 publications

Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index

Metabolomic Pathways Predicting Labor Dystocia by Maternal Body Mass Index

Newborn Screening Samples for Diabetes Research: An Underused Resource

Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence

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