Cord Blood Levels of IL-6, IL-8 and IL-10 May Be Early Predictors of Bronchopulmonary Dysplasia in Preterm Newborns Small for Gestational Age

Abstract

Introduction: Various cytokines have been associated to the occurrence of bronchopulmonary dysplasia (BPD) in preterm neonates. AIM: To establish an association between cord blood cytokines and BPD, so that they could be used, in clinical practice, as early markers of BPD. Material and methods: Preterms less than 30 weeks gestational age, were analysed by ELISA microassay for venous cord blood IL-1β, IL-6, IL-8, TNF-α and IL-10, and compared between the BPD and non-BPD groups. Results: One hundred and fifty neonates completed the study; 31 (21%) small for gestational age (SGA); 16 were deceased before 28 days of life; 36 developed mild BPD and 20 developed moderate/severe BPD. Elevated cord blood IL-8 was associated with death or moderate/severe BPD. SGA patients with moderate/severe BPD presented higher cord blood values of IL-8, lower IL-6 and IL-10 when compared with SGA without moderate/severe BPD; and higher IL-8 levels when compared with patients without moderate/severe BPD. Conclusion: These results support an association between cord blood IL-8 and moderate/severe BPD, independently of the intra-uterine growth; and the association of cord blood IL-6 and IL-10 and moderate/severe BPD in SGA preterm newborns.

MicroRNA-214 Prevents Pulmonary Angiogenesis and Alveolarization in Rat Models with Bronchopulmonary Dysplasia via PlGF-Dependent STAT3 Signaling Pathway

“…IL-6 is a typical proin ammatory cytokine which plays a functional role in a number of physiological in ammatory and immunological processes [34]. It has been supported that there is a close correlation between the dysregulation of IL-6 with moderate and severe BPD in preterm infants with a small gestational age [35]. PlGF overexpression contributes an exaggerated in ammatory state [36].…”

Features of Immune Response in Preterm Babies With Bronchopulmonary Displasia of Various Severity

“…Результаты исследования Rocha G. и соавт. (2012) демонстрируют существование ассоциаций между повышенным уровнем IL-8 и низким содержанием IL-6, IL-10 в пуповинной крови детей с БЛД среднетяжелой и тяжелой степени [18].…”

Safety of lipid emulsion in very low‐birthweight infants according to cytokine level

“…14 SGA infants have high inflammatory cytokines such as IL-8, but no significant changes in IL-6 or TNF-α. 15 High IL-8 may be correlated with bronchopulmonary dysplasia severity in SGA infants, 16 and cytokines may also be related to prenatal infection. 17 The current study is the first to examine changes in cytokine levels with i.v.…”