Cord blood banks collect units with different HLA alleles and haplotypes to volunteer donor banks: a comparative report from Swiss Blood stem cells

Meyer-Monard, Sandrine; Passweg, Jakob; Troeger, Carolyn; Eberhard, Hans-Peter; Roosnek, Eddy; Faveri, Grazia Nicoloso de; Chalandon, Yves; Rovó, Alicia; Kindler, Vincent; Irion, Olivier; Holzgreve, Wolfgang; Gratwohl, Aloïs; Müller, Carlheinz; Thewis, André; Tiercy, Jean‐Marie

doi:10.1038/bmt.2008.391

Cited by 15 publications

(14 citation statements)

References 18 publications

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“…The HLA-A-B-DRB1 haplotype frequencies found in this study are very close (although with regional variations) to previous estimations done in 2008 by the ZKRD (the German donors registry) [7] and in 2010 by the BMDW on the whole Swiss data pooled together [45], and this is also true for haplotypes including the HLA-C locus. However, our approach has the advantage of taking ambiguities into account to estimate frequencies and is thus much more precise than in other studies.…”

Section: Discussionsupporting

confidence: 89%

The Heterogeneous HLA Genetic Makeup of the Swiss Population

et al. 2012

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This study aims at investigating the HLA molecular variation across Switzerland in order to determine possible regional differences, which would be highly relevant to several purposes: optimizing donor recruitment strategies in hematopoietic stem cell transplantation (HSCT), providing reliable reference data in HLA and disease association studies, and understanding the population genetic background(s) of this culturally heterogeneous country. HLA molecular data of more than 20,000 HSCT donors from 9–13 recruitment centers of the whole country were analyzed. Allele and haplotype frequencies were estimated by using new computer tools adapted to the heterogeneity and ambiguity of the data. Non-parametric and resampling statistical tests were performed to assess Hardy-Weinberg equilibrium, selective neutrality and linkage disequilibrium among different loci, both in each recruitment center and in the whole national registry. Genetic variation was explored through genetic distance and hierarchical analysis of variance taking into account both geographic and linguistic subdivisions in Switzerland. The results indicate a heterogeneous genetic makeup of the Swiss population: first, allele frequencies estimated on the whole national registry strongly deviate from Hardy-Weinberg equilibrium, by contrast with the results obtained for individual centers; second, a pronounced differentiation is observed for Ticino, Graubünden, and, to a lesser extent, Wallis, suggesting that the Alps represent(ed) a barrier to gene flow; finally, although cultural (linguistic) boundaries do not represent a main genetic differentiation factor in Switzerland, the genetic relatedness between population from south-eastern Switzerland and Italy agrees with historical and linguistic data. Overall, this study justifies the maintenance of a decentralized donor recruitment structure in Switzerland allowing increasing the genetic diversity of the national—and hence global—donor registry. It also indicates that HLA data of local donor recruitment centers can be used as reference data in both epidemiological and population genetic studies focusing on the genetic history of present European populations.

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Section: Discussionsupporting

confidence: 89%

The Heterogeneous HLA Genetic Makeup of the Swiss Population

et al. 2012

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“…2 The importance of a re-consent before final release of the UCB sample for allogeneic transplantation single-step two-step concern about misuse doesn't matter n=26 n=154 n=107 Fig. 3 Different attitudes, concerns and consent procedures before release of a rejected UCB sample for research purposes investment would rather lead to fewer UCB donors from the population, considering that a third of them are of immigrant background with most probably limited financial resources [4].…”

Section: Discussionmentioning

confidence: 99%

“…They provide stem cell transplants with rare HLA alleles and haplotypes that are scarcely found in bone marrow registries [4]. However, far more UCB units have been stored in private institutions.…”

Section: Introductionmentioning

confidence: 99%

Controversies in hybrid banking: attitudes of Swiss public umbilical cord blood donors toward private and public banking

Manegold

Meyer-Monard

Thewis

et al. 2010

Arch Gynecol Obstet

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Purpose Umbilical cord blood (UCB) stored in public inventories has become an alternative stem cell source for allogeneic stem cell transplantation. The potential use of autologous UCB from private banks is a matter of debate. In the face of the limited resources of public inventories, a discussion on ''hybrid'' public and private UCB banking has evolved. We aimed to explore the attitudes of the donating parents toward public and private UCB banking. Study design and methods A standardized, anonymous questionnaire was sent to the most recent 621 public UCB donors including items regarding satisfaction with recruitment process, the need for a second consent before release of the UCB unit for stem cell transplantation, and the donors' views on public and private UCB banking. Furthermore, we asked about their views on UCB research. Results Of the questionnaires, 48% were returned, and 16% were lost due to mail contact. Of our donors, 95% would donate to the public bank again. As much as 35% of them were convinced that public banking was useful. Whereas 27% had never heard about private UCB banking, 34% discussed both options. Nearly 70% of donors opted for public banking due to altruism and the high costs of private banking. Of our public UCB donors, 81% stated that they did not need a re-consent before UCB release for stem cell transplantation. In case of sample rejection, 53.5% wanted to know details about the particular research project. A total of 9% would not consent. Conclusions Almost all donors would choose public banking again due to altruism and the high costs of private banking. Shortly after donation, mail contact with former UCB donors was difficult. This might be a relevant issue in any sequential hybrid banking.

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“…9 and hence it is likely that the Arab ethnicity is underrepresented in the western cord blood banks. Many western banks now aim at recruiting nonCaucasian individuals for cord blood units and a recent study showed that some DRB1 alleles occurred at higher frequency in cord blood banks than unrelated donor registries, 14 likely because of increased recruitment of cord blood donation from ethnic minorities. In our study, 96 of the 97 reported patients received units from western cord blood banks, and 47% of the units were one-Ag mismatched.…”

Section: Second Transplantsmentioning

confidence: 99%

“…Thus, many such countries are now supporting the establishment of national cord blood banks to enhance the probability of finding suitable units for their nationals who need SCT but have no suitable matched family donor. [11][12][13][14] In Saudi Arabia, there is currently no national donor program registry, and until September 2008 there was no national cord blood bank. The first case of UCB transplant in Saudi Arabia was performed in January 2003 at King Faisal Specialist Hospital and Research Center (KFSHRC), and until the opening of the Saudi National Bank, all the units were procured from western banks.…”

Section: Introductionmentioning

confidence: 99%

Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia

Ayas

Al-Seraihi

Al‐Jefri

et al. 2009

Bone Marrow Transplant

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In unrelated cord blood (UCB) transplantation, survival has been shown to correlate with the degree of HLA matching. Thus, to extend transplant access to different ethnic backgrounds, many western UCB transplantation banks now encourage donation from non-Caucasians. Until recently, Saudi Arabia did not have a national UCB bank. In this study we report our experience in UCB transplantation in children using units procured from western cord blood banks. A total of 97 children underwent unrelated UCB transplantation at King Faisal Specialist Hospital and Research Center (KFSHRC), of which 95 were of Arab ethnicity. A total of 30 patients had malignant disorders, 25 patients had non-malignant hematological disorders and 42 patients had inborn errors. Conditioning was according to disease, with six patients receiving reduced-intensity regimens. In all, 46 patients received one-Ag-mismatched units and 51 received twoAg-mismatched units. Engraftment occurred in 93% of patients, the 100-TRM was 15%, acute GVHD developed in 20% of patients and chronic GVHD occurred in 9% of patients. The 5-year OS and EFS estimates were 52 and 43%, respectively. The search for UCB transplantation units for Saudi patients in western banks yielded reasonably compatible units for our patients; the results are consistent with published data. Our data are encouraging for UCB transplant programs in countries in which there are no national UCB transplantation banks.

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Cord blood banks collect units with different HLA alleles and haplotypes to volunteer donor banks: a comparative report from Swiss Blood stem cells

Cited by 15 publications

References 18 publications

The Heterogeneous HLA Genetic Makeup of the Swiss Population

The Heterogeneous HLA Genetic Makeup of the Swiss Population

Controversies in hybrid banking: attitudes of Swiss public umbilical cord blood donors toward private and public banking

Unrelated cord blood transplantation in pediatric patients: a report from Saudi Arabia

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