Corannulene‐Incorporated AIE Nanodots with Highly Suppressed Nonradiative Decay for Boosted Cancer Phototheranostics In Vivo

Gu, Xinggui; Zhang, Xiaoyan; Ma, Huili; Jia, Shaorui; Zhang, Pengfei; Zhao, Yanjun; Liu, Qian; Wang, Jianguo; Zheng, Xiaoyan; Lam, Jacky W. Y.; Ding, Dan; Tang, Ben Zhong

doi:10.1002/adma.201801065

Cited by 172 publications

(115 citation statements)

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“…[4] Furthermore,they also exhibit enhanced 1 O 2 generation in the aggregate state. [5] These features make the nanoparticles of AIEgens particularly suitable as PSs for image-guided PDT. [6] Thec ommon method to improve the photosensitization efficiency of PSs is based on the enhancement of the intersystem crossing (ISC) from the lowest excited state (S 1 ) to the lowest triplet state (T 1 ).…”

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confidence: 99%

Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect

et al. 2018

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Ap articular challenge in the design of organic photosensitizers (PSs) with donor-acceptor (D-A) structures is that it is based on trial and error rather than specific rules.Now these challenges are addressed by proposing two efficient strategies to enhance the photosensitization efficiency:p olymerization-facilitated photosensitization and the D-A evenodd effect. Conjugated polymers have been found to exhibit ah igher 1 O 2 generation efficiency than their small molecular counterparts.F urthermore,P Ss with A-D-A structures show enhanced photosensitization efficiency over those with D-A-D structures.T heoretical calculations suggest an enhanced intersystem crossing (ISC) efficiency by these strategies.B oth in vitro and in vivo experiments demonstrate that the resulting materials can be used as photosensitizers in image-guided photodynamic anticancer therapy. These guidelines are applicable to other polymers and small molecules to lead to the development of new PSs.

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confidence: 99%

Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect

et al. 2018

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“…Besides, a functionalized AIEgen used for image‐guided PDT owing to bright far‐red/near‐infrared fluorescence emission and high singlet oxygen ( 1 O 2 ) production was investigated . New NIR‐II emission molecule AIEgens were reported for photoacoustic and dual fluorescence brain‐tumor imaging, and AIE dots and polymeric fluorescent PS NPs were developed for PDT in vivo models.…”

Section: Key Application In Biomedicinementioning

confidence: 99%

Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

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et al. 2019

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The advances in bioinformatics and biomedicine have promoted the development of biomedical imaging and theranostic systems to respectively extend the endogenous biomarker imaging with high contrast and enhance the therapeutic effect with high efficiency. The emergence of biomacromolecule‐functionalized aggregation‐induced emitters (AIEgens), utilizing AIEgens, and biomacromolecules (nucleic acids, peptides, glycans, and lipids), displays specific targeting ability to cancer cell, improved biocompatibility, reduced toxicity, enhanced therapeutic effect, and so forth. This review summarizes the rational design of biomacromolecule‐functionalized AIEgens and their biomedical applications in recent ten years, including high‐resolution optical imaging of cell, tissue, and small animal model with low background; the biomarker detection for early diagnosis and prognosis; the delivery and monitoring of prodrugs; image‐guide photodynamic therapy and its combination with chemotherapy. Through illustrating their functional mechanisms and application, it is hoped that this review would open up a completely new train of research thought for attracted researchers in various fields.

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“…Very recently, image‐guided tumor surgery with NIR fluorescence has been available in the clinic and ICG has been popularly used. Several recent studies on NIR‐emissive AIEgen probes for image‐guided cancer surgery have demonstrated that when compared with ICG, the AIEgens show higher fluorescence quantum yield in biological environments, better photostability, and stronger RONS resistance at the disease sites . Thereby, AIEgens hold great promise for clinical translation although still a long way off, which needs the joint efforts of research groups, companies, and medical institutions.…”

Section: Summary and Perspectivesmentioning

confidence: 99%

Unity Makes Strength: How Aggregation‐Induced Emission Luminogens Advance the Biomedical Field

et al. 2018

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research fields to provide new opportunities for precise and personalized medical treatment of patients. [16][17][18][19][20][21][22][23][24][25][26][27] An ideal fluorescent agent should have low toxicity, high brightness, excellent stability, good selectivity, and versatile functionality. To date, a vast variety of synthetic fluorescent materials, including organic dyes, [28][29][30] fluorescent proteins, [31,32] inorganic quantum dots (QDs), [33,34] conjugated polymer nanoparticles (NPs), [35][36][37][38][39][40] metallic nanoclusters, [41] as well as upconversion NPs, [42][43][44] have been explored and demonstrated for biological applications.Among the above-mentioned fluorescent materials, synthetic organic dyes and dye-loaded fluorescent NPs have attracted special attention due to the good biocompatibility and easy availability. However, a considerable number of organic dyes are hydrophobic, which often form aggregation through π-π stacking in aqueous solutions and buffers even though different strategies have been applied to improve their water solubility. The serious π-π stacking interactions among dye molecules facilitate nonradiative pathways to relax the exciton energy, leading to partially or completely quenched fluorescence. This phenomenon is well known as aggregation-caused quenching (ACQ) effect, [45] which is the main obstacle of construction of highly emissive fluorescence bioprobes in complicated biological microenvironments. Although great efforts have been made from various aspects to overcome the notorious undesired ACQ effect, [46] it remains a major challenge for the significant improvement of traditional fluorescent bioprobes in biomedicine and life sciences.In 2001, Tang and co-workers discovered a novel fluorescent phenomenon that is opposite to the ACQ effect: the organic Figure 4. Confocal images of Hela cancer cells after incubation with A-D) A6-A9 (5 × 10 −6 m) for 15 min, respectively. Adapted with permission. [104]

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Corannulene‐Incorporated AIE Nanodots with Highly Suppressed Nonradiative Decay for Boosted Cancer Phototheranostics In Vivo

Cited by 172 publications

References 44 publications

Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect

Strategies to Enhance the Photosensitization: Polymerization and the Donor–Acceptor Even–Odd Effect

Biomacromolecule‐Functionalized AIEgens for Advanced Biomedical Studies

Unity Makes Strength: How Aggregation‐Induced Emission Luminogens Advance the Biomedical Field

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