Coral Tree (
            <i>Erythrina variegata</i>
            L.)

Alam, Khairul; Akhtaruzzaman, Mohammad

doi:10.1079/9781789248067.0010

Cited by 1 publication

(1 citation statement)

References 46 publications

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“…6,8–14 Currently, many studies have isolated flavonoids from E. variegata with isoflavonoids reported as the primary constituents among prenyl isoflavones, flavan-3-ols, flavonols with sugar moieties, and triterpenoids. 15–32 Given its rich chemical composition, several studies have investigated the plant’s biological activities, such as antibacterial effects, 22,33–35 antioxidant activity, 5,36 pain relief, anti-inflammatory effects, 36–39 cardiovascular effects, 40 anticonvulsant effects, and anxiolytic effects. 3,5,8,41–44 However, there is limited research on the antidiabetic effects of this plant.…”

Section: Introductionmentioning

confidence: 99%

Potential protein tyrosine phosphatase 1B and α-glucosidase inhibitory flavonoids from Erythrina variegata: Experimental and computational results

Nguyen,

Trinh,

et al. 2024

Journal of Chemical Research

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Erythrina variegata L., a member of the Fabaceae family, is a valuable medicinal plant with a rich history of traditional medicinal uses. However, its potential as an antidiabetic agent has remained largely unexplored. In this study, three isoflavonoid compounds, namely eryvarin M (1), eryvarin H (2), and neobavaisoflavone (3), were isolated from E. variegata. These compounds displayed significant inhibitory effects on both protein tyrosine phosphatase 1B and α-glucosidase enzymes. The specific attachment position of the prenyl group to the isoflavonoid skeleton plays a pivotal role in determining the variation in their activity. Moreover, the results obtained from docking simulations corroborate the experimental findings, confirming the robust binding affinities of these metabolites toward the target proteins. The docking analysis further highlights that these compounds exhibit highly negative values of binding-free energies against proteins, indicative of their favorable binding affinities. In addition, the formation of hydrogen bonds in the binding region contributes to their binding interactions. These findings significantly enhance our understanding of the therapeutic potential of both E. variegata and its isoflavonoids as potential inhibitors for diabetes and related metabolic disorders, shedding light on their promising role in the field of diabetes research.

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