2022
DOI: 10.3324/haematol.2021.280578
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Copy number alterations define outcome in Philadelphia chromosome-positive acute lymphoblastic leukemia

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Cited by 1 publication
(1 citation statement)
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References 16 publications
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“…10 Additional stud ies sup port this fi nd ing, with Ph + ALL with IKZF1 plus alter ations (IKZF1 dele tions with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG dele tion 16 ) appearing to be par tic u larly resis tant to ther apy. [17][18][19][20] In addi tion, dele tions in CDKN2A/2B have been asso ci ated with a poor prog no sis after allo ge neic hema to poi etic cell trans plan ta tion (HCT) in first com plete response (CR) due to a high relapse rate. 21 Conversely, long dele tions of MEF2C and K-Ras have been asso ci ated with improved CR rate and, in the case of MEF2C, improved dis ease-free sur vival.…”
Section: Biology and Prog No Sismentioning
confidence: 99%
“…10 Additional stud ies sup port this fi nd ing, with Ph + ALL with IKZF1 plus alter ations (IKZF1 dele tions with deletions in CDKN2A, CDKN2B, PAX5, or PAR1 in the absence of ERG dele tion 16 ) appearing to be par tic u larly resis tant to ther apy. [17][18][19][20] In addi tion, dele tions in CDKN2A/2B have been asso ci ated with a poor prog no sis after allo ge neic hema to poi etic cell trans plan ta tion (HCT) in first com plete response (CR) due to a high relapse rate. 21 Conversely, long dele tions of MEF2C and K-Ras have been asso ci ated with improved CR rate and, in the case of MEF2C, improved dis ease-free sur vival.…”
Section: Biology and Prog No Sismentioning
confidence: 99%