Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells

Zaidman, Ben-Zion; Wasser, Solomon P.; Nevo, Eviatar; Mahajna, Jamal

doi:10.1007/s11033-007-9059-5

Cited by 52 publications

(45 citation statements)

References 42 publications

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“…Mycelia extracts of C. comatus have been also studied revealing antioxidant potential (Tsai et al, 2009) and some extracts proved to interfere with androgen receptor function in LNCaP prostate cancer cells (Zaidman et al, 2008). The hypoglycemic effect, as also the improvement of glucose tolerance, was still presented by C. comatus mycelium (Ding et al, 2010) and by some polysaccharides extracted from selenium-enriched mycelia (Yu et al, 2009).…”

mentioning

confidence: 99%

Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F.Müll.) Pers.

Stojković

Reis

Barros

et al. 2013

Food and Chemical Toxicology

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confidence: 99%

Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F.Müll.) Pers.

Stojković

Reis

Barros

et al. 2013

Food and Chemical Toxicology

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“…The results showed that the treatment with DHT caused an appreciable increase in the level of PSA whereas treatment with flutamide caused a moderate reduction in the PSA production level. However, with the C. comatus extract treatment, a significant decrease in the level of PSA levels in a dose-dependent manner [42].…”

Section: Antibacterial Potentials Of C Comatus Extractsmentioning

confidence: 94%

“…Furthermore, Srivastava and Sharma showed that the antimicrobial activity of mushroom depends on the solvent used for extraction as well as the strain of the fungus. However, interestingly, they also reported that a significantly higher concentration of the C. comatus extract was needed to cause 50 % growth inhibition of the other tested cell lines, meaning that the C. comatus extract had an appreciable level of selectivity toward LNCaP cell lines, as compared to the extracts of G. lucidum which showed lesser selectivity [42]. The study also showed that the extracts of C. comatus were able to selectively affect the cell cycle progression of prostate cancer PCa cell lines, comprised LNCaP, PC-3, and DU 145.…”

Section: Antibacterial Potentials Of C Comatus Extractsmentioning

confidence: 99%

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Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

Ukaegbu

Jalal²,

Rashid³

et al. 2017

Asian J Pharm Clin Res

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The pharmacological potential of bioactive compounds extracted from mushrooms has been studied to a reasonable level. In the same vein, the bioactivity of nanoparticles has also been investigated and reported to be of potential pharmacological benefit. No doubt, there is a reasonable amount of claims regarding the vast activity of the mushroom extracts and nanoparticles on the tested cell lines and microorganisms. In this paper, a review of the recent application of bioactive compounds extracted from two edible mushrooms (Coprinus comatus and Lactarius deliciosus), as well as some of the recently reported studies on some nanoparticles of pharmacological potentials, was carried out. In order to check for synergy in the bioactivity of the mushroom extracts when co-administered with nanoparticles, an investigation on the synergistic application of the materials through the encapsulation of the bioactive extracts from the mushroom onto the nanoparticle was proposed. The supposed synergy in the activity of the extract-nanoparticle complex could hold the key to improved activity of nutraceuticals against resistant microorganisms and tumor cells.

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“…It was reported that G. lucidum spores and the fruiting body (FB) extracts inhibited activator protein-1 (AP-1) and NF-κB (24,25). Recently, a G. lucidum organic extract was shown to interfere with the androgen receptor function, a molecular target implicated in prostate cancer development, inducing G1 arrest in androgen-dependent but not in androgenindependent prostate cancer cell lines (26).…”

Section: Fungal Metabolites Modulating Nf-κ κB Activitymentioning

confidence: 99%

Fungal metabolites modulating NF-κB activity: An approach to cancer therapy and chemoprevention (Review)

Petrova

Reznick²,

Wasser³

et al. 2008

Oncol Rep

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Abstract.Fighting cancer is considered one of the most important areas of research in medicine and immunology. Due to the ability of cancer cells to mutate and become resistant to available drugs, new scientific approaches, focused on molecular mechanisms of carcinogenesis, are needed. A new direction in cancer treatment has arisen, devoted to the adjuvant use of natural bioactive compounds in conventional chemotherapy. This kind of research is gaining more attention. In particular, fungi can be used not only as strong immunoceuticals but also as a source of potent metabolites, capable of penetrating cell membranes and interfering with particular signal transduction pathways linked to processes such as inflammation, cell differentiation and survival, carcinogenesis, and metastasis. One such a crucial pathway involved in the above-mentioned processes, is the activation of the nuclear transcription factor κB (NF-κB). This review compiles the available data on fungal metabolites, known to modulate the activity of NF-κB, thus demonstrating their potential use as novel anti-cancer agents in the rapidly advancing field of molecular therapy. Contents1. Introduction 2. Fungal metabolites modulating NF-κB activity 3. Perspectives IntroductionCancer is the second most predominant cause of death in the modern world, after cardiovascular diseases, taking many human lives every year. Depending on the stage of cancer progression, treatments include surgical operation, radiotherapy and chemotherapy. However, their side effects cause serious damage and suffering to patients. As an alternative to these treatment methods, immunotherapy is now gaining more attention than ever. Immunotherapy substantially reduces the side effects and the inherent pain of cancer sufferred by patients and helps to overcome cancer growth, even in the last stages of the disease.Despite the observed success of most of the chemotherapeutic regimes, cellular adaptations have enabled tumor cells to evade many of these drugs. The nuclear transcription factor κB (NF-κB) is one of the factors responsible for cellular chemoresistance. It is a dimeric transcription factor belonging to the Rel/NF-κB family of transcription factors (1-4). The NF-κB complex is maintained in the cytoplasm in an inactive form by the inhibitory protein κB (IκBα), belonging to a family of inhibitory proteins, IκBs. The major activator of NF-κB is the IκB kinase complex (IKK). This complex is composed of two catalytic subunits, IKK-α and -ß and a regulatory subunit, IKK-γ (also known as NEMO) (2). The NF-κB pathway is triggered by bacterial and viral infections as well as pro-inflammatory cytokines and chemokines [e.g., tumor necrosis factor α (TNF-α), lipopolysaccharide (LPS), interleukins (IL-1, IL-6)], all of which activate the IKK complex. After activation, the IKK complex phosphorylates NF-κB-bound IκBs, thereby targeting them for proteasomal degradation. Simultaneously, the NF-κB dimers are released and free to enter the nucleus where transcriptional activation of target genes be...

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Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells

Cited by 52 publications

References 42 publications

Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F.Müll.) Pers.

Nutrients and non-nutrients composition and bioactivity of wild and cultivated Coprinus comatus (O.F.Müll.) Pers.

Between the Bioactive Extracts of Edible Mushrooms and Pharmacologically Important Nanoparticles: Need for the Investigation of a Synergistic Combination - A Mini Review

Fungal metabolites modulating NF-κB activity: An approach to cancer therapy and chemoprevention (Review)

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