Copper, zinc and magnesium plasma levels in epilepsy.

Blood Levels of Trace Elements, Electrolytes, and Oxidative Stress/Antioxidant Systems in Epileptic Patients

“…It alters Ca 2+ mobilization and stabilizes excitable membranes and also exerts a voltage-dependent blockage of the NMDA-receptor channel (54). In our study, Mg 2+ was unaltered in all groups of epileptics, and this is consistent with many studies (12,24,46) (Tables 2 and 4). In contrast, many studies reported low Mg 2+ levels in epileptics (3,42), particularly in association with hypocalcemia and hypokalemia (49,55), and this was attributed to the hyperexcitability in their uncontrolled epileptic patients (42) and increased seizure frequencies (56).…”

“…However, the results of different studies are conflicting. This can be mainly explained by the differences in the materials and methods, most studies have not been prospective, patients receiving different AEDs were classified in the same group, and the information about the patients included was not satisfactory in most of the studies (23,24,29). In addition, The duration of drug treatment and the prescribed dose are important variables.…”

Estimation of serum zinc and copper levels patients with schizophrenia: a preliminary study

“…In the peripheral and central nervous systems they play important functional roles and are also components in nervous tissue (3)(4)(5)(6)(7)(8). Imbalances in the optimum levels of these elements may adversely affect biological processes and are associated with many psychiatric diseases including schizophrenia (9)(10)(11).…”

Serum zinc levels are low in children with simple febrile seizures compared with those in children with epileptic seizures and controls

“…8 Another study found no difference in plasma zinc levels between an epileptic group and controls. 9 Experimental studies have shown that zinc inhibits Na-K-ATPase activity, leading to neuronal excitability and resulting in seizures. 8,10 However, zinc also has anti-epileptic activity as it modulates glutamic acid decarboxylase activity.…”

“…4 Individual studies have shown that serum zinc levels are low in children with febrile 4-7 and epileptic seizures. 8,9 There is a paucity of information regarding serum zinc levels in children with simple febrile and epileptic seizures. This study investigated serum zinc levels in children with epileptic and simple febrile seizures and compared them with levels in controls.…”