Copper uptake, essentiality, toxicity, detoxification and risk assessment in soil-plant environment

Shabbir, Zunaira; Sardar, Aneeza; Shabbir, Abrar; Abbas, Ghulam; Shamshad, Saliha; Khalid, Sana; Natasha,; Murtaza, Ghulam; Dumat, Camille; Shahid, Muhammad

doi:10.1016/j.chemosphere.2020.127436

Cited by 244 publications

(101 citation statements)

References 290 publications

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“…High levels of Cu affect key processes in plant development and growth, including the uptake of micro-and macronutrients, the reduction of pigment contents altering the photosynthesis process, and root expansion [30,31]. However, some plant species have a wide range of mechanisms to deal with metal stress and stop or at least diminish its deleterious effects on cellular processes [32]. Our study evidenced a noticeable difference in the transcriptomic response of root organs in comparison to shoot tissues in I. cylindrica growing under Cu stress conditions.…”

Section: Discussionmentioning

confidence: 99%

Main Molecular Pathways Associated with Copper Tolerance Response in Imperata cylindrica by de novo Transcriptome Assembly

Vidal

Larama

Riveros

et al. 2021

Plants

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The metallophyte Imperata cylindrica inhabits copper (Cu) polluted soils in large areas from Central Chile. Here, we subjected clonal vegetative plantlets to 300 mg Cu kg−1 of substrate for 21 days to identify the main molecular pathways involved in the response to Cu stress. Transcriptomic analyses were performed for shoots and roots, with and without Cu supply. RNA-Seq and de novo transcriptome assembly were performed to identify the gene response associated with molecular mechanisms of Cu tolerance in I. cylindrica. De novo transcriptome revealed a total of 200,521 transcripts (1777 bp) comprising ~91% complete ultra-conserved genes in the eukaryote and Plantae database. The differentially expressed genes (DEGs) in roots were 7386, with 3558 of them being up-regulated and the other 3828 down-regulated. The transcriptome response in shoots was significantly less, showing only 13 up-regulated and 23 down-regulated genes. Interestingly, DEGs mainly related with actin and cytoskeleton formation, and to a minor degree, some DEGs associated with metal transporters and superoxide dismutase activity in root tissues were found. These transcriptomic results suggest that cytoskeleton could be acting as a mechanism of Cu-binding in the root, resulting in a high Cu tolerance response in this metallophyte, which deserve to be analyzed ultra-structurally. Our study contributes to reinforcing the potential of I. cylindrica as a candidate plant species to be used as a phytoremediation agent in Cu-contaminated environments.

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Section: Discussionmentioning

confidence: 99%

Main Molecular Pathways Associated with Copper Tolerance Response in Imperata cylindrica by de novo Transcriptome Assembly

Vidal

Larama

Riveros

et al. 2021

Plants

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“…[5,7] In addition, copper is also utilized in both clinical applications and medicine due to its antimicrobial and biostatic properties. [4,8] On the other hand, Cu is classified as heavy metal that cannot be degraded by biological processes and may show toxic or carcinogenic properties as a result of their accumulation in living bodies. [6,8] Environmental pollution caused by this heavy metal creates serious problems for human health.…”

Section: Introductionmentioning

confidence: 99%

“…[4,8] On the other hand, Cu is classified as heavy metal that cannot be degraded by biological processes and may show toxic or carcinogenic properties as a result of their accumulation in living bodies. [6,8] Environmental pollution caused by this heavy metal creates serious problems for human health. According to authorities, the required daily copper intake for living organisms was established in different amounts.…”

Section: Introductionmentioning

confidence: 99%

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A Simple and Efficient Extraction Method for the Preconcentration of Copper in Tap Water and Linden Tea Samples Prior to FAAS Measurement

et al. 2021

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In this study, a simple, low‐cost and eco‐friendly analytical method namely syringe assisted pipette tip dispersive solid phase extraction (SA‐PT‐DSPE) combined with slotted quartz tube‐flame atomic absorption spectrometry (SQT‐FAAS) system was presented for the determination of copper at trace levels in linden tea and tap water samples. Under the optimal experimental conditions, limit of detection (LOD) and quantification (LOQ) values obtained for the SA‐PT‐DSPE‐SQT‐FAAS system were calculated as 3.7 and 12.5 μg/L, respectively. The SA‐PT‐DSPE‐SQT‐FAAS system provided a 44.0‐folds improvement in detection power of the conventional FAAS. The recovery results for tap water samples were calculated close to 100 % via external calibration strategy. Negative matrix effects on the analyte were observed for linden tea samples. Therefore, recovery studies were performed by matrix matching calibration strategy and percentage recoveries were found to be between 88.0–102.0 % with low standard deviation values.

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“…Toxic concentrations of copper can occur when copper ingestion is over 1 g (usually taken in suicide attempts) and the estimated lethal dose in an untreated adult is 10-20 g. Systemic toxicity occurs at serum copper levels of 78.5 µmol/L [27]. The human body makes contact with a large variety of sources of cooper, including copper water pipes, copper cookware, drinking water, foods, birth control pills and Cu intrauterine devices, vitamin and minerals supplements, fungicides and added copper in swimming pools [25,28]. These concerns regarding copper toxicity must be taken into account for biologically active copper complexes.…”

Section: Introductionmentioning

confidence: 99%

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

2020

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Every year, more Cu(II) complexes are proven to be biologically active species, but very few are developed as drugs or entered in clinical trials. This is due to their poor water solubility and lipophilicity, low stability as well as in vivo inactivation. The possibility to improve their pharmacological and/or oral administration profile by incorporation into inorganic or organic matrix was studied. Most of them are either physically encapsulated or conjugated to the matrix via a moiety able to coordinate Cu(II). As a result, a large variety of species were developed as delivery carriers. The organic carriers include liposomes, synthetic or natural polymers or dendrimers, while the inorganic ones are based on carbon nanotubes, hydrotalcite and silica. Some hybrid organic-inorganic materials based on alginate-carbonate, gold-PEG and magnetic mesoporous silica-Schiff base were also developed for this purpose.

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Copper uptake, essentiality, toxicity, detoxification and risk assessment in soil-plant environment

Cited by 244 publications

References 290 publications

Main Molecular Pathways Associated with Copper Tolerance Response in Imperata cylindrica by de novo Transcriptome Assembly

Main Molecular Pathways Associated with Copper Tolerance Response in Imperata cylindrica by de novo Transcriptome Assembly

A Simple and Efficient Extraction Method for the Preconcentration of Copper in Tap Water and Linden Tea Samples Prior to FAAS Measurement

Improvement in the Pharmacological Profile of Copper Biological Active Complexes by Their Incorporation into Organic or Inorganic Matrix

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