Copper Triflate: An Efficient Catalyst for Direct Conversion of Secondary Alcohols into Azides

Lewis Acid Catalysed Chemoselective Amination of Alcohols Using Heterocyclic Thiones: An Avenue to Thiotetrazole Derivatives

“…[21][22][23][24] We speculated that a similar approach may enable direct alcohol arylation as Lewis acid catalyst provides powerful strategy to facilitate activation and derivatisation of alcohols via an S N 1 and S N 2 type pathway. [25][26][27] To our surprise, a limited number of Lewis acid promoted selective amination and sulfenylation of alcohols with thiotetrazoles are developed. Our on-going studies on mild and efficient synthetic methods for producing chemo selective aminated product led to potentially examine more convenient and safe catalysts.…”

“…In contemporary organic synthesis, Lewis acid catalysed reactions have gained increasing popularity because of the unique reactivity and selectivity that can be easily achievable under mild reaction conditions [21–24] . We speculated that a similar approach may enable direct alcohol arylation as Lewis acid catalyst provides powerful strategy to facilitate activation and derivatisation of alcohols via an S N 1 and S N 2 type pathway [25–27] . To our surprise, a limited number of Lewis acid promoted selective amination and sulfenylation of alcohols with thiotetrazoles are developed.…”

Green Regio‐ and Enantioselective Aminolysis Catalyzed by Graphite and Graphene Oxide under Solvent‐Free Conditions

“…As reported in Table 4, highe nantioselectivities were obtained with all the amines.T he absolute configuration was determined by comparison with reported HPLC data. [51] Notably,a sf or the regioselective control,r educed enantioselectivities for benzylamine, pyrrolidine, andp iperidine ( Table 4, entries 2a nd 4) were detected, possibly due to the competitive autocatalytic pathwayt hat is responsible for racemization of (S)-styrene oxide during the course of the reaction.…”

“…The use of heterogeneous catalyst as solids (e.g.,silica gel, [29] nanosilica, [30] functionalized mesoporouss ilica, [31][32][33] alumina and/or modifieda lumina, [34][35][36][37] nanoaluminos ilicates, [38][39][40][41][42] montmorillonite-K10 clay, [43] sulfated zirconia, [44,45] annotitanium dioxides, [46] heteropolya cids, [47] polyoxometalatei norganic metal oxygen clusters, [48] Amberlyst-15, [49] nanocrystalline zircosilicate, [50] and iron oxides [51] )h as tried to meet the need for more sustainable protocols that assure good regioselective control,o ften lost to competitive polymerization/isomerization of the epoxides.…”