Copper trafficking inTrypanosoma cruzi: the transcriptional response of candidates to balance toxicity and recruitment
Marcelo L. Merli,
María G. Mediavilla,
Xinyu Zhu
et al.
Abstract:Trypanosoma cruzi (Chagas disease) depends on acquiring nutrients and cofactors, like copper (Cu), from its hosts. Cu is essential for aerobic organisms, but it can also be toxic, so its transport and storage must be regulated. In the present study, we characterized the effects of changes in Cu availability on growth, intracellular ion content, and oxygen consumption. Our results show that Cu is essential for epimastigote proliferation and for metacyclogenesis, while intracellular amastigotes suffered from Cu … Show more
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