Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging

Wang, Junxin; Hsu, Su Wen; Gonzalez‐Pech, Natalia I.; Jhunjhunwala, Anamik; Chen, Fang; Hariri, Ali; Grassian, Vicki H.; Tao, Andrea R.; Jokerst, Jesse V.

doi:10.1002/ppsc.201900171

Cited by 14 publications

(14 citation statements)

References 47 publications

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“…or nanocomposites. [222,223] In addition, the distinctive therapeutic capability of Cu-based nanosystems endows them with PA imaging-guided therapeutic performances.…”

Section: Cu-involved Contrast Agents For Bioimagingmentioning

confidence: 99%

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The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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As an essential trace element in the human body, transitional metal copper (Cu) ions are the bioactive components within the body featuring dedicated biological effects such as promoting angiogenesis and influencing lipid/glucose metabolism. The recent substantial advances of nanotechnology and nanomedicine promote the emerging of distinctive Cu‐involved biomaterial nanoplatforms with intriguing theranostic performances in biomedicine, which are originated from the biological effects of Cu species and the physiochemical attributes of Cu‐composed nanoparticles. Based on the very‐recent significant progresses of Cu‐involved nanotheranostics, this work highlights and discusses the principles, progresses, and prospects on the elaborate design and rational construction of Cu‐composed functional nanoplatforms for a diverse array of biomedical applications, including photonic nanomedicine, catalytic nanotherapeutics, antibacteria, accelerated tissue regeneration, and bioimaging. The engineering of Cu‐based nanocomposites for synergistic nanotherapeutics is also exemplified, followed by revealing their intrinsic biological effects and biosafety for revolutionizing their clinical translation. Finally, the underlying critical concerns, unresolved hurdles, and future prospects on their clinical uses are analyzed and an outlook is provided. By entering the “Copper Age,” these Cu‐involved nanotherapeutic modalities are expected to find more broad biomedical applications in preclinical and clinical phases, despite the current research and developments still being in infancy.

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“…or nanocomposites. [222,223] In addition, the distinctive therapeutic capability of Cu-based nanosystems endows them with PA imaging-guided therapeutic performances.…”

Section: Cu-involved Contrast Agents For Bioimagingmentioning

confidence: 99%

“…On this ground, photothermal Cu‐involved nanoagents have been extensively explored in PA imaging of tumors in diverse formulations or nanocomposites. [ 222,223 ] In addition, the distinctive therapeutic capability of Cu‐based nanosystems endows them with PA imaging‐guided therapeutic performances.…”

Section: Cu‐involved Contrast Agents For Bioimagingmentioning

confidence: 99%

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

et al. 2020

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“…The CuS triangular nanoprisms are subsequently produced by addition of CuS seeds to the growth solution. [ 174,175 ]…”

Section: Methods Of Synthesismentioning

confidence: 99%

Nonspherical Metal‐Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity

Zare

Zheng

Makvandi

et al. 2021

Small

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Metal‐based nanoentities, apart from being indispensable research tools, have found extensive use in the industrial and biomedical arena. Because their biological impacts are governed by factors such as size, shape, and composition, such issues must be taken into account when these materials are incorporated into multi‐component ensembles for clinical applications. The size and shape (rods, wires, sheets, tubes, and cages) of metallic nanostructures influence cell viability by virtue of their varied geometry and physicochemical interactions with mammalian cell membranes. The anisotropic properties of nonspherical metal‐based nanoarchitectures render them exciting candidates for biomedical applications. Here, the size‐, shape‐, and composition‐dependent properties of nonspherical metal‐based nanoarchitectures are reviewed in the context of their potential applications in cancer diagnostics and therapeutics, as well as, in regenerative medicine. Strategies for the synthesis of nonspherical metal‐based nanoarchitectures and their cytotoxicity and immunological profiles are also comprehensively appraised.

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“…Both PNPs displayed a fairly high efficiency, 0.366 and 0.490 respectively, at 1064 nm excitation [ 158 ]. Suitability of CuS nanodisks and nanoprisms as PAI contrast agents was demonstrated at excitation wavelength of 920 nm for ovarian cancer imaging with an in vivo concentration of 5.4 nM [ 159 ]. Our laboratory exploited a photoacoustic method to attain the determination of the Q A / Q E ratio of covellite CuS nanoflakes for 1064 nm excitation.…”

Section: Photothermal Conversion By Innovative Plasmonic Nanomaterialsmentioning

confidence: 99%

Optothermal properties of plasmonic inorganic nanoparticles for photoacoustic applications

Gellini

Feis

2021

Photoacoustics

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Plasmonic systems are becoming a favourable alternative to dye molecules in the generation of photoacoustic signals for spectroscopy and imaging. In particular, inorganic nanoparticles are appealing because of their versatility. In fact, as the shape, size and chemical composition of nanoparticles are directly correlated with their plasmonic properties, the excitation wavelength can be tuned to their plasmon resonance by adjusting such traits. This feature enables an extensive spectral range to be covered. In addition, surface chemical modifications can be performed to provide the nanoparticles with designed functionalities, e.g., selective affinity for specific macromolecules. The efficiency of the conversion of absorbed photon energy into heat, which is the physical basis of the photoacoustic signal, can be accurately determined by photoacoustic methods. This review contrasts studies that evaluate photoconversion in various kinds of nanomaterials by different methods, with the objective of facilitating the researchers' choice of suitable plasmonic nanoparticles for photoacoustic applications.

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Copper Sulfide Nanodisks and Nanoprisms for Photoacoustic Ovarian Tumor Imaging

Cited by 14 publications

References 47 publications

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

The Coppery Age: Copper (Cu)‐Involved Nanotheranostics

Nonspherical Metal‐Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity

Optothermal properties of plasmonic inorganic nanoparticles for photoacoustic applications

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