Copper Spinel Ferrite Superparamagnetic Nanoparticles as a Novel Radiotherapy Enhancer Effect in Cancer Treatment

Meidanchi, Alireza; Ansari, H. Z. A. Fouad

doi:10.1007/s10876-020-01832-5

Cited by 29 publications

(13 citation statements)

References 41 publications

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“…Source heating is more effective and less invasive, whereas water bath heating is more pertinent for metastasis cancers. The chief limitations of hyperthermia treatment are local inhomogeneous thermal heating of affected region and abysmal heating of deeply located effected regions [8]. Hence, to deal with these limitations nanotechnology based treatment practices are widely studied nowadays.…”

Section: Hyperthermiamentioning

confidence: 99%

“…Spinel ferrite nano ranged magnetic particles (SFNMs) are ferrimagnets with exemplary magnetic characteristics, that are highly dependent on particle size and shape anisotropy [1]. SFNMs are generally divalent ion doped spinel metal oxides structures which have plenty of applications in storage [2] , electromagnetic devices [3], catalysis [4] sensing [5], targeted drug delivery [6], diagnosis and imaging [7], thermotherapic cancer treatment [8] and waste water contamination removal [9]. The doped cations are randomly arranged on two crystallographic sites in spinel structure and their arrangement determines the optical, magnetic and electrical characteristics of the SFNMs [10,11,12,13].…”

Section: Introductionmentioning

confidence: 99%

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Suitability of Ferrites for Biomedical Applications

Dhiman

2021

Materials Research Foundations

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This chapter aims at the latest amelioration in the biomedical application of spinel ferrites. Magnetic hyperthermia treatment of tumour cells and contrast resonance imaging of human body parts, are a few applications of spinel ferrites that have gained substantial interest nowadays. The thermo-therapeutic and radiology based diagnosis treatment has many benefits over traditional methods used for disease diagnosis and imaging treatment of chronic carcinogenic origin diseases. The various types of doped and undoped spinel ferrite nanoparticles are investigated and optimised for different biomedical applications. Through this chapter, an attempt is made to provide readers the knowledge about various required characteristics and latest used strategies for the successful implementations of spinel ferrite in biomedical applications at commercial levels.

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Section: Hyperthermiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Suitability of Ferrites for Biomedical Applications

Dhiman

2021

Materials Research Foundations

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“…The nanomedicine field had contributed significantly to improving the potency, lowering the toxicity margin of treatments in diseases like cancer (Hussein et al, 2012;Ibrahim et al, 2020). The applications may include increasing the precision of treatments such as radiotherapy and phototherapy (Ardakani et al, 2020;Meidanchi, 2020a;Meidanchi and Ansari, 2020;Meidanchi and Motamed, 2020). The use of nanoparticles with their unique properties may also help in overcoming the low solubility of hydrophobic agents like curcumin (Wang et al, 2013;Jafarzadeha et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

Hassani¹,

Hussain²,

Al‐Qubaisi³

et al. 2022

Biocell

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“…Cancer is the second leading cause of death and, as such, it is a global health concern [ 1 ]. It is caused by uncontrolled cell proliferation, reduced cell death rate, or both [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

Mushtaq¹,

Shahzad²,

Saeed³

et al. 2021

Beilstein J. Nanotechnol.

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In this study, poly(isobutylene-alt-maleic anhydride) (PMA)-coated spinel ferrite (MFe2O4, where M = Fe, Co, Ni, or Zn) nanoparticles (NPs) were developed as carriers of the anticancer drugs doxorubicin (DOX) and methotrexate (MTX). Physical characterizations confirmed the formation of pure cubic structures (14–22 nm) with magnetic properties. Drug-loaded NPs exhibited tumor specificity with significantly higher (p < 0.005) drug release in an acidic environment (pH 5.5). The nanoparticles were highly colloidal (zeta potential = −35 to −26 mV) in deionized water, phosphate buffer saline (PBS), and sodium borate buffer (SBB). They showed elevated and dose-dependent cytotoxicity in vitro compared to free drug controls. The IC50 values ranged from 0.81 to 3.97 μg/mL for HepG2 and HT144 cells, whereas IC50 values for normal lymphocytes were 10 to 35 times higher (18.35–43.04 µg/mL). Cobalt ferrite (CFO) and zinc ferrite (ZFO) NPs were highly genotoxic (p < 0.05) in cancer cell lines. The nanoparticles caused cytotoxicity via oxidative stress, causing DNA damage and activation of p53-mediated cell cycle arrest (significantly elevated expression, p < 0.005, majorly G1 and G2/M arrest) and apoptosis. Cytotoxicity testing in 3D spheroids showed significant (p < 0.05) reduction in spheroid diameter and up to 74 ± 8.9% of cell death after two weeks. In addition, they also inhibited multidrug resistance (MDR) pump activity in both cell lines suggesting effectivity in MDR cancers. Among the tested MFe2O4 NPs, CFO nanocarriers were the most favorable for targeted cancer therapy due to excellent magnetic, colloidal, cytotoxic, and biocompatible aspects. However, detailed mechanistic, in vivo cytotoxicity, and magnetic-field-assisted studies are required to fully exploit these nanocarriers in therapeutic applications.

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Copper Spinel Ferrite Superparamagnetic Nanoparticles as a Novel Radiotherapy Enhancer Effect in Cancer Treatment

Cited by 29 publications

References 41 publications

Suitability of Ferrites for Biomedical Applications

Suitability of Ferrites for Biomedical Applications

Curcumin gum Arabic nanoparticles demonstrate potent antioxidant and cytotoxic properties in human cancer cells

Biocompatibility and cytotoxicity in vitro of surface-functionalized drug-loaded spinel ferrite nanoparticles

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