Copper Regulation of Ceruloplasmin in Copper-Deficient Rats

Abstract

In copper-deficient rats, oral intubation of copper increases the rate of ceruloplasmin synthesis without affecting general synthesis of plasma or liver proteins. It also restores the enzyme from half to full activity. Copper given by injection at doses commonly employed has additional nonspecific effects on protein synthesis and in some strains of rats produces severe hemolysis. In contrast to deficient rats, in normal rats copper does not elevate plasma ceruloplasmin unless hemolysis also occurs. Thus, at least in deficiency, copper availability controls the rate of synthesis, activation, and plasma concentration of cemloolasmin.

Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation

“…Serum copper can't be used because it builds up in an albumin, copper, TM complex in the blood. Cp is made by the liver at a rate dependent upon the availability of copper to incorporate into the protein [50]. At that point, I teamed up with an oncologist, Dr. Sofia Merajver, for further work.…”

Ceruloplasmin as an Indicator of Copper Reserves in Wild Ruminants at High Latitudes

“…The suppression of affinity may be associated with depletion of Cu at the active sites of the enzyme. This hypothesis is supported by the restoration of serum ceruloplasmin activity following administration of Cu to Cu-deficient rats (Linder et al, 1979) presumably through restored synthesis of the enzyme with fully functional active sites containing Cu. Restoration of ceruloplasmin activity and kinetics in Cu deficient ungulates awaits direct confirmation.…”

Carcinofetal Isoferritins

“…Some workers feel that the tumor isoferritins contain subunits unique to cancer or fetal cells [3,27,401. Others think that these variants are not unique to cancer or fetal tissues, but are also found in trace amounts in normal tissues such as heart and kidney [6,25,341.…”

“…This effect is reversible so that after removalofexcess iron by diet or phlebotomy, the patterns shift to the more acidic forms normally found in heart, kidney and pancreas [34,371. These observations may relate to femtin phenotypes in cancer tissues which often have low iron levels compared to the normal tissue [27]. Such differences in phenotypic expression in cancer cells cannot simply be a reflection of differences in iron status.…”