Copper-polymer nanocomposites: An excellent and cost-effective biocide for use on antibacterial surfaces

Tamayo, Laura; Azócar, Manuel; Kogan, Marcelo J.; Riveros, Ana; Páez, Maritza

doi:10.1016/j.msec.2016.08.041

Cited by 284 publications

(171 citation statements)

References 141 publications

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“…The incorporation of copper ions into MMT, a natural material, could also reduce the problems of their release in the environment, even if copper ions resulted to be significantly less toxic (and cheaper) than silver ions 11 ; nevertheless the ecotoxicity of nanomaterials released from nanocomposites deserve further investigations to consider the risks and implication for Environmental Health Safety. They represent the first example of epoxy nanocomposite in which the copper modified clay was able to impart biocidal properties even in very low amount, where the good dispersion was obtained only after a strong milling and subsequent drying of the Cu 21 -MMT filler, achieving an acceptable compatibilization between the organic polymeric matrix and the inorganic clay, even in the absence of an organic modifier.…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Cu²⁺‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Bartolozzi

Bertani

Burigo

et al. 2017

J of Applied Polymer Sci

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Multifunctional nanocomposites can be achieved by addition of modified layered nanoclays to impart to the final materials a designed set of properties. The easy reproducible preparation of copper modified montmorillonite has been reported here together with its spectroscopic characterization, including 29Si NMR in the solid state. Epoxy-nanocomposites and glass fiber reinforced laminates containing 1% wt and 3% wt of Cu2+-MMT have been prepared and characterized. Thermal and mechanical properties have been evaluated. The experiments carried out to evaluate the antibacterial activity showed that the epoxy-resin nanocomposites with 3% wt of Cu2+-MMT exhibited an inhibition action higher than 96% against Escherichia coli and Staphylococcus aureus

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Section: Discussionmentioning

confidence: 99%

Multifunctional Cu²⁺‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Bartolozzi

Bertani

Burigo

et al. 2017

J of Applied Polymer Sci

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“…Of a variety of nanofillers used to form nanocomposite materials, metal oxides have been popular, because they can improve the mechanical characteristics, and the electrical and transport properties, of the composites …”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Of a variety of nanofillers used to form nanocomposite materials, metal oxides have been popular, because they can improve the mechanical characteristics, and the electrical and transport properties, of the composites. [8][9][10][11][12] Cerium dioxide is a promising, but as yet poorly studied, metal oxide nanofiller. Polymer-based composite materials containing nanoceria are capable of screening electromagnetic irradiation, and they possess good catalytic activity and biological activity.…”

Section: Introductionmentioning

confidence: 99%

Unexpected selective enhancement of the thermal stability of aromatic polyimide materials by cerium dioxide nanoparticles

Gofman

Nikolaeva

Yakimansky

et al. 2019

Polymers for Advanced Techs

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The unusual effect of selective enhancement of the thermal stability of aromatic polyimide materials was established through the introduction of cerium dioxide nanoparticles into these polymers as nanofiller. Depending on the chemical structure of the polymers, a marked increase or a substantial decrease in the thermal stability of the nanocomposite material was registered by thermal analysis, as compared with that of unfilled polymer material. The positive effect was registered only for the composite materials based on the matrix polyimides containing the sulfur atoms located in the sulfonic groups arranged in the elementary units. The results of the thermogravimetric examination are compared with the data obtained during the mechanical tests of the same samples. The possible reasons for the alteration of the thermal stability of polymers by ceria nanoparticles are discussed. The effect above can be of substantial practical interest providing new options for the design of polyimide nanocomposite materials with enhanced thermal stability.

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“…If copper ions get into the bacteria, they can bind to the DNA and become involved in cross-linking within nucleic acid strands with the result that the bacteria cannot replicate. Furthermore copper ions generate reactive oxygen species and can cause lipid peroxidation and protein oxidation[47]. …”

Section: Resultsmentioning

confidence: 99%

Copper as an alternative antimicrobial coating for implants - an in vitro study

Bergemann

Zaatreh

Wegner

et al. 2017

WJT

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AIMTo investigate osteoconductive and antimicrobial properties of a titanium-copper-nitride (TiCuN) film and an additional BONIT® coating on titanium substrates.METHODSFor micro-structuring, the surface of titanium test samples was modified by titanium plasma spray (TPS). On the TPS-coated samples, the TiCuN layer was deposited by physical vapor deposition. The BONIT® layer was coated electrochemically. The concentration of copper ions released from TiCuN films was measured by atomic absorption spectrometry. MG-63 osteoblasts on TiCuN and BONIT® were analyzed for cell adhesion, viability and spreading. In parallel, Staphylococcus epidermidis (S. epidermidis) were cultivated on the samples and planktonic and biofilm-bound bacteria were quantified by counting of the colony-forming units.RESULTSField emission scanning electron microscopy (FESEM) revealed rough surfaces for TPS and TiCuN and a special crystalline surface structure on TiCuN + BONIT®. TiCuN released high amounts of copper quickly within 24 h. These release dynamics were accompanied by complete growth inhibition of bacteria and after 2 d, no planktonic or adherent S. epidermidis were found on these samples. On the other hand viability of MG-63 cells was impaired during direct cultivation on the samples within 24 h. However, high cell colonization could be found after a 24 h pre-incubation step in cell culture medium simulating the in vivo dynamics closer. On pre-incubated TiCuN, the osteoblasts span the ridges and demonstrate a flattened, well-spread phenotype. The additional BONIT®coating reduced the copper release of the TiCuN layer significantly and showed a positive effect on the initial cell adhesion.CONCLUSIONThe TiCuNcoating inhibits the formation of bacterial biofilms on orthopedic implants by influencing the “race for the surface” to the advantage of osteoblasts.

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Copper-polymer nanocomposites: An excellent and cost-effective biocide for use on antibacterial surfaces

Cited by 284 publications

References 141 publications

Multifunctional Cu²⁺‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Multifunctional Cu²⁺‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Unexpected selective enhancement of the thermal stability of aromatic polyimide materials by cerium dioxide nanoparticles

Copper as an alternative antimicrobial coating for implants - an in vitro study

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Copper-polymer nanocomposites: An excellent and cost-effective biocide for use on antibacterial surfaces

Cited by 284 publications

References 141 publications

Multifunctional Cu2+‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Multifunctional Cu2+‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Unexpected selective enhancement of the thermal stability of aromatic polyimide materials by cerium dioxide nanoparticles

Copper as an alternative antimicrobial coating for implants - an in vitro study

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Product

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Multifunctional Cu²⁺‐montmorillonite/epoxy resin nanocomposites with antibacterial activity

Multifunctional Cu²⁺‐montmorillonite/epoxy resin nanocomposites with antibacterial activity