Copper

Aspin, Ν.; Sass-Kortsāk, Andrew

doi:10.1016/b978-0-12-135301-8.50008-x

Cited by 8 publications

(4 citation statements)

References 101 publications

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“…Intestin al absorption of copper is influenced by the diet ary contents of other trace met als , ascorbic acid , intestinal pH , and other factors , and by the clinical sta te and even a transiently impaired absorp tion (13,14). When these factors are taken into…”

Section: Discussionmentioning

confidence: 99%

Nutritional Copper Deficiency in Severely Handicapped Patients on a Low Copper Enteral Diet for a Prolonged Period

Higuchi,

Higashi,

Nakamura

et al. 1988

J. pediatr. gastroenterol. nutr.

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Summary:Six cases of nutritional copper deficiency were identified in a nursery institute for severely handicapped patients. All had been on prolonged enteral feeding of a copper‐deficient diet and all had abnormalities related to the copper deficiency. Two of them had leuko‐penia, with or without macrocytic and normochromic anemia. After the oral administration of copper, the clinical and laboratory observations including neutrophil counts and serum copper and ceruloplasmin levels showed a complete recovery. The dietary copper requirement was estimated to be ∼20 μg/kg/day for these patients, based on the correlation between the dietary copper intake and the levels of copper in the serum.

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Section: Discussionmentioning

confidence: 99%

Nutritional Copper Deficiency in Severely Handicapped Patients on a Low Copper Enteral Diet for a Prolonged Period

Higuchi,

Higashi,

Nakamura

et al. 1988

J. pediatr. gastroenterol. nutr.

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“…As an integral part of at least 16 metalloproteins, copper has essential tasks, in particular in connective tissue metabolism, in the CNS and in haematopoiesis (75,76). Copper is also jointly responsible for enteral iron absorption (77).…”

Section: Alimentary Disordermentioning

confidence: 99%

Classification and differential diagnosis of Wilson’s disease

Hermann

2019

Ann. Transl. Med

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Wilson's disease is characterized by hepatic and extrapyramidal movement disorders (EPS) with variable manifestation primarily between age 5 and 45. This variability often makes an early diagnosis difficult. A classification defines different clinical variants of Wilson's disease, which enables classifying the current clinical findings and making an early tentative diagnosis. Until the unequivocal proof or an autosomal recessive disorder of the hepatic copper transporter ATP7B has been ruled out, differential diagnoses have to be examined. Laboratory-chemical parameters of copper metabolism can both be deviations from the norm not related to the disease as well as other copper metabolism disorders besides Wilson's disease. In addition to known diseases such as Menkes disease, occipital horn syndrome (OHS), Indian childhood cirrhosis (ICC) and ceruloplasmin deficiency, recently discovered disorders are taken into account. These include MEDNIK syndrome, Huppke-Brendel syndrome and CCS chaperone deficiency. Another main focus is on differential diagnoses of childhood icterus correlated with age and anaemia as well as disorders of the extrapyramidal motor system. The Kayser-Fleischer ring (KFR) is qualified as classical ophthalmologic manifestation. The recently described manganese storage disease presents another rare metabolic disorder with symptoms similar to Wilson's disease. As this overview shows, Wilson's disease fits into a broad spectrum of internal and neurological disease patterns with icterus, anaemia and EPS.

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“…Some trace metals are used as metalloenzymes (e.g., Zn, Fe, Cu and Mn) for the synthesis of hormones (e.g., iodine) and as modulators in enzyme activities (e.g., Cr in insulin actions). [1] Cu, Zn and Mn are important co-factors in the antioxidative activities of superoxide dismutase. [2] Deficiencies of any of these micronutrients have been associated with certain disease conditions.…”

Section: Introductionmentioning

confidence: 99%