Copper Oxide Nanoparticles Supported on Graphene Oxide‐ Catalyzed S‐Arylation: An Efficient and Ligand‐Free Synthesis of Aryl Sulfides

Abstract

Copper oxide nanoparticles that are supported on graphene oxide as a catalytic system have been utilized for ligand‐free and solvent‐free CS cross‐coupling reactions with weak bases such as triethylamine. Symmetrical/unsymmetrical aryl sulfides have been synthesized by the coupling of different aryl halides with aromatic as well as aliphatic sulfides. Surprisingly, aryl chlorides also well reacted with different types of sulfides in the presence of dimethyl sulfoxide and cesium carbonate. Besides, this catalytic system is suitable for the synthesis of phenothiazines via cascade CS and CN cross‐coupling of ortho‐dihalides and ortho‐aminobenzothiazoles. In addition, this alternative approach is extremely useful for the synthesis of a variety of symmetrical diaryl sulfides by using thiourea as a sulfur source that is devoid of the foul smell of thiols. Indeed, the calculated E‐factor value of our present protocol is 2.52. Furthermore, this protocol is particularly attractive as an environmentally benign and practical method for the synthesis of different aryl sulfides. Moreover, the heterogeneous catalytic system described in this process represents not only a greener approach but retains its significant activity for up to six catalytic cycles.magnified image

Carbon Nanocomposites: Preparation and Its Application in Catalytic Organic Transformations

“…The results showed that the N-doped Cu catalyst has good stability in the formic acid decomposition even at 478 K for at least 7 h on-stream and a significantly higher catalytic activity. Kamal et al [64] prepared GO-based nanocomposite (CuO@GO), and it was utilized for ligandfree and solvent-free C▬N and C▬S cross-coupling reactions with weak bases such as triethylamine (Scheme 10). They found that the CuO@GO is a simple and efficient catalyst for solvent-and ligand-free C▬S cross-coupling reactions in the presence of weak bases and relatively mild reaction conditions by using the CuO@GO catalytic system.…”

Synthesis, Properties of Graphene Oxide-Metal Oxide Mixed Nanocomposites and their Applications - Review

“…So many works has been done on Graphene based materials, Graphene oxide based materials and metal oxide nanoparticles, but few works has been done on Graphene oxide-metal oxide mixed nanocomposites. For example, Ahmed Kamal et al reported that Copper Oxide-Graphene Oxide mixed nanoparticles acts as a catalyst in synthesis of ligand free Aryl sulphides [34].In another work; GO based CuO NPs composite electrode is used for highly enhanced non enzymatic glucose detection [35].…”

Engineering nanocomposite membranes: Addressing current challenges and future opportunities

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