Copper oxide nanoparticles infused electrospun polycaprolactone/gelatin scaffold as an antibacterial wound dressing

Karuppannan, Sathish Kumar; Ramalingam, Raghavendra; Khalith, S.B. Mohamed; Musthafa, Shazia Anjum; Dowlath, Mohammed Junaid Hussain; Munuswamy-Ramanujam, Ganesh; Arunachalam, Kantha Deivi

doi:10.1016/j.matlet.2021.129787

Cited by 38 publications

(13 citation statements)

References 21 publications

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“…In publication [ 62 ], the antibacterial properties of the nanofibers based on polycaprolactone and gelatin containing 1 wt.% CuO NPs were studied. It was determined that the nanofibers have a strong antibacterial activity against the Gram-positive S. aureus (51 ± 1.2 mm), the multidrug resistant S. aureus (40 ± 1.7 mm) and the Gram-negative P. aeruginosa (31 ± 0.5 mm) and the E. coli (30.5 ± 0.3 mm) bacteria, which was explained by the authors through generation of the reactive oxygen intermediates that destroy bacterial cells by cell membrane oxidation.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

Yudaev

Mezhuev

Chistyakov

2022

Gels

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The dressings containing nanoparticles of metals and metal oxides are promising types of materials for wound repair. In such dressings, biocompatible and nontoxic hydrophilic polymers are used as a matrix. In the present review, we take a look at the anti-microbial effect of the nanoparticle-modified wound dressings against various microorganisms and evaluate their healing action. A detailed analysis of 31 sources published in 2021 and 2022 was performed. Furthermore, a trend for development of modern antibacterial wound-healing nanomaterials was shown as exemplified in publications starting from 2018. The review may be helpful for researchers working in the areas of biotechnology, medicine, epidemiology, material science and other fields aimed at the improvement of the quality of life.

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Section: Resultsmentioning

confidence: 99%

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

Yudaev

Mezhuev

Chistyakov

2022

Gels

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“…Moreover, the antibacterial performance was also notably enhanced due to the encapsulation of Fe 3 O 4 nanoparticles. The existing studies also reported the design and development of electrospun ternary nanofiber mats with different multifunctional performances for wound dressing applications, such as ferric oxide/gelatin/glycerol nanofiber mats [ 116 ], copper oxide nanoparticle/gelatin/PCL nanofiber mats [ 117 ], cerium oxide nanoparticle/gelatin/PCL nanofiber mats [ 118 ], sliver nanoparticle/gelatin/PVA nanofiber mats [ 119 ], tellurium nanoparticle/gelatin/PCL nanofiber mats [ 120 ], and halloysite nanotube/gelatin/PCL nanofiber mats [ 121 ].…”

Section: Electrospun Gelatin-based Nanofibersmentioning

confidence: 99%

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

Sun

2022

Nanomaterials

130

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Electrospun nanofiber materials have been considered as advanced dressing candidates in the perspective of wound healing and skin regeneration, originated from their high porosity and permeability to air and moisture, effective barrier performance of external pathogens, and fantastic extracellular matrix (ECM) fibril mimicking property. Gelatin is one of the most important natural biomaterials for the design and construction of electrospun nanofiber-based dressings, due to its excellent biocompatibility and biodegradability, and great exudate-absorbing capacity. Various crosslinking approaches including physical, chemical, and biological methods have been introduced to improve the mechanical stability of electrospun gelatin-based nanofiber mats. Some innovative electrospinning strategies, including blend electrospinning, emulsion electrospinning, and coaxial electrospinning, have been explored to improve the mechanical, physicochemical, and biological properties of gelatin-based nanofiber mats. Moreover, numerous bioactive components and therapeutic agents have been utilized to impart the electrospun gelatin-based nanofiber dressing materials with multiple functions, such as antimicrobial, anti-inflammation, antioxidation, hemostatic, and vascularization, as well as other healing-promoting capacities. Noticeably, electrospun gelatin-based nanofiber mats integrated with specific functions have been fabricated to treat some hard-healing wound types containing burn and diabetic wounds. This work provides a detailed review of electrospun gelatin-based nanofiber dressing materials without or with therapeutic agents for wound healing and skin regeneration applications.

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“…Karuppannan et al added CuO nanoparticles to PCL/gel fibers using a green synthesis method. The prepared CuONF had good mechanical properties and hydrophilicity and sustained in vitro drug release for 48 h. At the same time, it had an antibacterial effect on wound pathogenic bacteria and supported the growth of fiber cells, which are effective in wound care (Karuppannan et al, 2021). Copper-Based Antibacterial Hydrogels…”

Section: Application Of Copper-based Biomaterials Copper-based Antibacterial Scaffoldsmentioning

confidence: 99%

Advances in Copper-Based Biomaterials With Antibacterial and Osteogenic Properties for Bone Tissue Engineering

Shen

Kong

et al. 2022

Front. Bioeng. Biotechnol.

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Treating bone defects coupled with pathogen infections poses a formidable challenge to clinical medicine. Thus, there is an urgent need to develop orthopedic implants that provide excellent antibacterial and osteogenic properties. Of the various types, copper-based biomaterials capable of both regenerating bone and fighting infections are an effective therapeutic strategy for bone tissue engineering and therefore have attracted significant research interest. This review examines the advantages of copper-based biomaterials for biological functions and introduces these materials’ antibacterial mechanisms. We summarize current knowledge about the application of copper-based biomaterials with antimicrobial and osteogenic properties in the prevention and treatment of bone infection and discuss their potential uses in the field of orthopedics. By examining both broad and in-depth research, this review functions as a practical guide to developing copper-based biomaterials and offers directions for possible future work.

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Copper oxide nanoparticles infused electrospun polycaprolactone/gelatin scaffold as an antibacterial wound dressing

Cited by 38 publications

References 21 publications

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

Nanoparticle-Containing Wound Dressing: Antimicrobial and Healing Effects

State-of-the-Art Review of Electrospun Gelatin-Based Nanofiber Dressings for Wound Healing Applications

Advances in Copper-Based Biomaterials With Antibacterial and Osteogenic Properties for Bone Tissue Engineering

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