Copper nanoparticles for SERS-based determination of some cephalosporin antibiotics in spiked human urine

Markina, Natalia E.; Ustinov, Stanislav N.; Zakharevich, Andrey M.; Маркин, А. В.

doi:10.1016/j.aca.2020.09.016

Cited by 36 publications

(19 citation statements)

References 38 publications

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“…Therapeutic drug monitoring (TDM) involves assessing the drug concentration in a biological matrix (most commonly plasma or serum) at a known time related to administration and interpreting these concentrations in terms of relevant clinical parameters (target range and pharmacokinetics of the drug) (Jaworska et al, 2016). In TDM experiments, the easiest approach is simply to investigate the recorded SERS spectra of the body fluid (urine, blood, and blood plasma) that contains the drug of interest and monitor the intensity of the bands assigned to that drug (Markina et al, 2020). Unfortunately, due to the complexity of the sample, this procedure requires a bit of luck as spectral signatures of the drug are not necessarily seen in the recorded spectra because of the interference from the signals from the body fluid.…”

Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

Applications of Surface-Enhanced Raman Scattering in Biochemical and Medical Analysis

Szaniawska

Kudelski

2021

Front. Chem.

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In this mini-review, we briefly describe certain recently developed applications of the surface-enhanced Raman spectroscopy (SERS) for determining various biochemically (especially medically) important species from ones as simple as hydrogen cations to those as complex as specific DNA fragments. We present a SERS analysis of species whose characterization is important to our understanding of various mechanisms in the human body and to show its potential as an alternative for methods routinely used in diagnostics and clinics. Furthermore, we explain how such SERS-based sensors operate and point out future prospects in this field.

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Section: Therapeutic Drug Monitoringmentioning

confidence: 99%

Applications of Surface-Enhanced Raman Scattering in Biochemical and Medical Analysis

Szaniawska

Kudelski

2021

Front. Chem.

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“…For example, the authors demonstrated that the modification with β-CD-SH does not enable elimination of the negative effect of some metabolites (creatinine and corticosterone) which remarkably compete with the target analyte reducing its SERS signal. However, because the analysis of body fluids by SERS is really a challenging task due to strong competitive interactions with intrinsic body fluid components [ 5 , 7 ], more studies in this direction (particularly with real samples) are required before concluding the suitability of CD-SERS assays for such analysis and capability of CDs to improve selectivity.…”

Section: Analytical Performancementioning

confidence: 99%

“…Low selectivity significantly restricts application of SERS for analysis of complex mixtures such as body fluids, and several approaches have been proposed to overcome this limitation. The simplest one is the adjustment of pH, ionic strength, and/or dielectric constant of the analyzed solution to maximize interaction of analyte molecules with SERS substrate and minimize such interaction for admixtures [3][4][5]. The next approach implies preliminary separation of the analyte by chromatographic separation or by solid-phase/ liquid-liquid extraction [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin-assisted surface-enhanced Raman spectroscopy: a critical review

2021

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Numerous approaches have been proposed to overcome the intrinsically low selectivity of surface-enhanced Raman spectroscopy (SERS), and the modification of SERS substrates with diverse recognition molecules is one of such approaches. In contrast to the use of antibodies, aptamers, and molecularly imprinted polymers, application of cyclodextrins (CDs) is still developing with less than 100 papers since 1993. Therefore, the main goal of this review is the critical analysis of all available papers on the use of CDs in SERS analysis, including physicochemical studies of CD complexation and the effect of CD presence on the Raman enhancement. The results of the review reveal that there is controversial information about CD efficiency and further experimental investigations have to be done in order to estimate the real potential of CDs in SERS-based analysis. Graphical abstract

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“…The SERS enhancement mostly relies on the amplification of the electromagnetic field-i.e., electromagnetic (EM) hot spots generated by the excitation of the localized surface plasmon resonance (LSPR) of the metal nanostructures [17]. Therefore, plasmonic metallic nanostructures including Au, Ag, and Cu have been fabricated to prepare an excellent SERS substrate for sensing molecules [18][19][20]. Designing and optimizing the geometry of a plasmonic nanostructure, such as its size [21], sharp corners [22], tips [23], surface roughness [24], and interparticle gaps [25], is essential in order to provide a strong EM hotspot and hence enhance SERS signal intensities.…”

Section: Introductionmentioning

confidence: 99%

Hierarchically Assembled Plasmonic Metal-Dielectric-Metal Hybrid Nano-Architectures for High-Sensitivity SERS Detection

et al. 2022

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In this work, we designed and prepared a hierarchically assembled 3D plasmonic metal-dielectric-metal (PMDM) hybrid nano-architecture for high-performance surface-enhanced Raman scattering (SERS) sensing. The fabrication of the PMDM hybrid nanostructure was achieved by the thermal evaporation of Au film followed by thermal dewetting and the atomic layer deposition (ALD) of the Al2O3 dielectric layer, which is crucial for creating numerous nanogaps between the core Au and the out-layered Au nanoparticles (NPs). The PMDM hybrid nanostructures exhibited strong SERS signals originating from highly enhanced electromagnetic (EM) hot spots at the 3 nm Al2O3 layer serving as the nanogap spacer, as confirmed by the finite-difference time-domain (FDTD) simulation. The PMDM SERS substrate achieved an outstanding SERS performance, including a high sensitivity (enhancement factor, EF of 1.3 × 108 and low detection limit 10−11 M) and excellent reproducibility (relative standard deviation (RSD) < 7.5%) for rhodamine 6G (R6G). This study opens a promising route for constructing multilayered plasmonic structures with abundant EM hotspots for the highly sensitive, rapid, and reproducible detection of biomolecules.

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Copper nanoparticles for SERS-based determination of some cephalosporin antibiotics in spiked human urine

Cited by 36 publications

References 38 publications

Applications of Surface-Enhanced Raman Scattering in Biochemical and Medical Analysis

Applications of Surface-Enhanced Raman Scattering in Biochemical and Medical Analysis

Cyclodextrin-assisted surface-enhanced Raman spectroscopy: a critical review

Hierarchically Assembled Plasmonic Metal-Dielectric-Metal Hybrid Nano-Architectures for High-Sensitivity SERS Detection

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