Copper Nanoparticles Differentially Target Testis of the Catfish, Clarias batrachus: In vivo and In vitro Study

Murugananthkumar, Raju; Rajesh, Desapogu; Senthilkumaran, B.

doi:10.3389/fenvs.2016.00067

Cited by 18 publications

(4 citation statements)

References 56 publications

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“…Cu nanoparticles were introduced to Clarias bathrachus, a catfish species, resulting in damage to the basal lamina of the testicular tissue. This damage led to the presence of different types of spermatogonia and enlargement of spermatocytes (Murugananthkumar, Rajesh et al 2016). Zebrafish (Danio rerio) is widely recognized as the primary experimental fish in aquatic studies.…”

Section: Effects Of Nano Pollutants On Fish Reproductive Systemmentioning

confidence: 99%

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Koca

2023

Nanotechnology in Reproduction

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Nanoparticles (NPs) are small size molecules. It is divided into organic and inorganic. Organic NPs have many clinical uses, from inoculation to homeostasis, long-term storage and delivery to the system, and absorption of topically used drugs into the skin. Inorganic NPs can be used in intraoperative lymphatic scanning, tumors, and anemia treatments. NPs have a favorable effect on sperm motility, kinematic parameters or membrane integrity rates, they can also be used as antibacterial, antiviral and antifungal in genital organ diseases. There are many studies in which the addition of NPs can be beneficial or harmful to sperm. Researchers have stated that it may be beneficial or cytotoxic depending on in vivo (such as airway, skin or injection) or in vitro use. It has been reported that NPs have positive effects on motility, kinematic parameters, plasma membrane integrity, DNA damage and acrosomal integrity and can be used as an antioxidant. In addition, it has been reported that it can be used in sexsorting, bioimaging and nanopurification, and that more studies on NPs will increase in the coming years.

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Section: Effects Of Nano Pollutants On Fish Reproductive Systemmentioning

confidence: 99%

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Koca

2023

Nanotechnology in Reproduction

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“…CuO-NPs had negative impacts on the freshwater organisms and Hyphessobrycon eques , specifically on feeding, reproduction, and survival, with an increase in ROS, representing the potential CuO-NP effect on fresh water species [ 174 ]. In another study, CuNPs and CuSO 4 were examined with adult male catfish (Clarias batrachus) , where testis-related genes showed regulation, an increase in the level of androgens, and disruption in the structural analysis [ 175 ].…”

Section: Overview Of Organ Toxicity In Fish Induced By Copper and mentioning

confidence: 99%

Review of Copper and Copper Nanoparticle Toxicity in Fish

et al. 2020

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This review summarizes the present knowledge on the toxicity of copper and copper nanoparticles (CuNPs) to various fish species. In previous decades, the excessive usage of metal and metallic nanoparticles has increased significantly, increasing the probability of the accumulation and discharge of metals in various trophic levels of the environment. Due to these concerns, it is important to understand the toxicity mechanisms of metals and metallic nanoparticles before they lead to unhealthy effects on human health. In this review paper, we specifically focus on the effect of metal copper and CuNPs on different fish organs under different physiochemical parameters of various water bodies. Nowadays, different forms of copper have distinctive and specific usages, e.g., copper sulfate is a well-established pesticide which is used to control the growth of algae in lakes and ponds. Deactivating the fungi enzymes prevents fungal spores from germinating. This process of deactivation is achieved via the free cupric ions, which are established as the most toxic forms of copper. Complexes of copper with other ligands may or may not be bioavailable for use in aquatic organisms. On the other hand, CuNPs have shown cost-effectiveness and numerous promising uses, but the toxicity and availability of copper in a nanoparticle form is largely unknown, Additionally, physiochemical factors such as the hardness of the water, alkalinity, presence of inorganic and organic ligands, levels of pH, and temperature in various different water bodies affect the toxicity caused by copper and CuNPs. However, comprehensive knowledge and data regarding the pattern of toxicity for copper metal ions and CuNPs in marine organisms is still limited. In this review, we carry out a critical analysis of the availability of the toxicological profiles of copper metal ions and CuNPs for different fishes in order to understand the toxicity mechanisms of copper and CuNPs. We believe that this review will provide valuable information on the toxicological profile of copper, which will further help in devising safe guidelines for the usage of copper and CuNPs in a sustainable manner.

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“…Toxic effects of nano copper were also prominent in crustaceans [38]. It can also change movement parameters of fish spermatozoa as a study on O. mykiss shows [39] and cause critical changes in the reproductive organs and lower the survival rate of larvae and cause developmental damage [40][41][42]. Changes in gene expression induced by nano copper were tested among the other parameters as well.…”

Section: Effects Of Copper Nanoparticles On Gene Expressionmentioning

confidence: 99%

Changes of Gene Expression Patterns from Aquatic Organisms Exposed to Metal Nanoparticles

Kulasza

Skuza

2021

IJERPH

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Metal nanoparticles are used in various branches of industry due to their physicochemical properties. However, with intensive use, most of the waste and by-products from industries and household items, and from weathering of products containing nanoparticles, end up in the waters. These pollutants pose a risk to aquatic organisms, one of which is a change in the expression of various genes. Most of the data that focus on metal nanoparticles and their effects on aquatic organisms are about copper and silver nanoparticles, which is due to their popularity in general industry, but information about other nanoparticulate metals can also be found. This review aims to evaluate gene expression patterns in aquatic organisms by metal nanoparticles, specifying details about the transcription changes of singular genes and, if possible, comparing the changes in the expression of the same genes in different organisms. To achieve this goal, available publications tackling this problem are studied and summarized. Nanometals were found to have a modulatory effect on gene expression in different aquatic organisms. Data show both up-regulation and down-regulation of genes. Nano silver, nano copper, and nano zinc show a regulatory effect on genes involved in inflammation and apoptosis, cell cycle regulation and ROS defense as well as in general stress response and have a negative effect on the expression of genes involved in development. Nano gold, nano titanium, nano zinc, and nano iron tend to elevate the transcripts of genes involved in response to ROS, but also pro-apoptotic genes and down-regulate DNA repair-involved genes and anti-apoptotic-involved genes. Nano selenium showed a rare effect that is protective against harmful effects of other nanoparticles, but also induced up-regulation of stress response genes. This review focuses only on the effects of metal nanoparticles on the expression of various genes of aquatic organisms from different taxonomic groups.

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Copper Nanoparticles Differentially Target Testis of the Catfish, Clarias batrachus: In vivo and In vitro Study

Cited by 18 publications

References 56 publications

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

The Positive Effects of In Vivo/In Vitro Suplementation of Nanoparticles on Semen

Review of Copper and Copper Nanoparticle Toxicity in Fish

Changes of Gene Expression Patterns from Aquatic Organisms Exposed to Metal Nanoparticles

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