Copper Nanoparticles Decorated Halloysite Nanotube/Polyaniline Composites for High Performance Non-Enzymatic Glucose Sensor

Abstract

Developing high-performance sensors for glucose detection is of great significance in clinical diagnostics and life science. This paper presents a non-enzymatic electrochemical glucose sensor with high performance. The halloysite nanotube/polyaniline (HNT/PANI) nanocomposite was obtained by chemical oxidation polymerization of aniline on the surface of halloysite nanotubes, then a highly sensitive non-enzymatic glucose sensor based on Cu nanoparticles decorated halloysite nanotube/polyaniline (Cu-HNT/PANI) nanocomposite was fabricated by in situ reduction of Cu precursor on HNT/PANI nanotubes under mild condition. Benefits from the high specific surface area and abundant active sites of the conductive substrate, the Cu-HNT/PANI nanocomposites modified glass carbon electrodes (GCE) exhibited significantly enhanced glucose sensing performance. The glucose sensor based on Cu-HNT/PANI composite demonstrated an excellent linear relationship in glucose concentrations range of 0.01–5 mM. The sensitivity in low concentration range (0.01–0.1 mM) reached 434.0 μA mM−1 cm−2 with the detection limit of 0.27 μM (S/N = 3). Besides, the Cu-HNT/PANI composites modified GCE exhibited extraordinary selectivity, stability and reproducibility in glucose sensing. Taking advantage of the low cost and mild synthesis conditions, Cu-HNT/PANI is a promising glucose-sensing material with broad application prospect.

3D Nanocomposite with High Aspect Ratio Based on Polyaniline Decorated with Silver NPs: Synthesis and Application as Electrochemical Glucose Sensor

“…It is necessary to note that the structure under investigation acts as a potentiometric sensor while a wide range of PANI-based sensors are amperometric ones [ 3 ]. Obtained systems demonstrate a linear response in a range of glucose concentrations actual for real medical diagnostic applications while most of studies are devoted to achieving a low limit of detection [ 57 , 58 , 59 , 60 , 61 ].…”

Bimetallic Cobalt Copper Organic Framework Integrating Multi-Wall Carbon Nanotubes and Gold Nanoparticles for Glucose Sensor

“…For instance, Shakir et al prepared Ag nanopatterns from DNA template for glucose detection, the sensor obtained excellent recoveries in human blood serum. 8 Later, low-cost transition metal materials such as Cu, 10 Co, 11 Ni 12 and their oxides, 13 hydroxides, 14 sulfides, 15 metal organic frameworks 16 were developed.…”

Controlling Response of Polyaniline Towards Humidity by Self-Assembly Fatty Acids

“…Thus, various PANI-based chemi-resistors have been used for the sensing of acetone, toluene, methanol, ethanol, isopropanol, ammonia, formaldehyde, water vapor and so on. [13][14][15][16][17] The sensitive to water vapor of PANI based sensors is important in the case of humidity sensors. [18][19][20] However, it is distressing in the case of detecting other analytes mixture with water vapor.…”