Copper molybdenum sulfide (Cu₂MoS₄) nanoplates as a proficient electrocatalytic interface for enhancing the electrochemical redox signals of ofloxacin for detection in pharmaceutical samples

Abstract

The introduction of nanocatalysts into electrochemical sensing systems has opened up new opportunities in developing advanced electrochemical sensing devices with high sensitivity, selectivity, and stability. In this study, a novel...

Cu2MoS4 Nanocatalyst‐Based Electrochemical Sensor for Ofloxacin Electro‐Oxidation: Delineating the Combined Roles of Crystallinity and Morphology on the Analytical Performance

“…For the CMS-1 sample, the presence of Cu(NH 4 )MoS 4 phase as an intermediate phase in the fabrication of CMS materials results in a decrease in electrocatalytic activity, which was consistent with our previous reports. [9,14] Moreover, the obtained results from the CV measurements in [Fe(CN) 6 ] 3À /4À redox probe and OFX recorded at CMS-2/SPE and CMS-3/SPE revealed that the resulting nanocrystalline Cu 2 MoS 4 structures possessed higher OFX analytical performance in comparison with Cu(NH 4 )MoS 4 / Cu 2 MoS 4 NMs (CMS-1 sample). The outstanding analytical performance toward the OFX detection of the CMS-3/SPE as compared to the CMS-1/SPE and CMS-2/SPE is attributed to the synergetic effect of the single-crystalline nature and plate-like nanostructure of Cu 2 MoS 4 catalyst, which which was consistent with our findings in the CV, LSV, and CA measurements.…”

“…In addition, the oxidation peak current of OFX linearly increases when the scan rate increases, indicating the electrochemical oxidation of OFX toward three CMS-modified electrodes is a diffusion-controlled process. [9] The linear regression equations were in the following:…”

“…By considering the α value in the range 0.3 < α < 0.7, [19] the number of electron transfers was calculated to be 2, indicating the electrochemical oxidation of OFX was validated to be a two-electron transfer process and the result is in accordance with some previously proposed mechanism for the electrochemical irreversible oxidation of OFX. [9,20] From the intercept values from the regressions, the k s values of CMS-1/ SPE, CMS-2/SPE, and CMS-3/SPE were calculated to be 0.27, 0.33, and 0.37, respectively. The larger value of k s at the CMS-3/ SPE indicates that the high-quality crystalline and plate-like Cu 2 MoS 4 NMs accelerated the electron transfer at the electrode/ electrolyte solution interface, facilitating the charge transferability to the analyte.…”

“…[8] In recent work, our study has demonstrated that the Cu 2 MoS 4 nanostructures could become an excellent electrocatalytic platform for the electrochemical sensing enhancement towards OFX antibiotic. [9] Nonetheless, the morphology structure, phase composition, and size of nano-modifiers have great influences on the redox processes occurring on the electrode surface. The fabrication of CMS nanostructures-based electrochemical platform with suitable characteristics will enhance sensing properties and clarify the correlation between structural features and analytical performance.…”

An Electrochemical Sensor Based on Simple Nano-Modification for Sensitive Detection of Ofloxacin Residue in Animal Derived Food

“…1) is a synthetic fluoroquinolone antimicrobial agent with broadspectrum antimicrobial activity against most Gram-negative, some Gram-positive, and some anaerobic bacteria. 1,2 They are commonly used not only for the treatment of genitourinary, respiratory, and gastrointestinal infections in humans 3 but also for the cure of animal diseases. It is also widely used as a growth promoter in aquaculture and poultry farming.…”