In this paper, the loss analysis and reduction strategy of gallium nitride (GaN) devices in high frequency buck converter are studied. To solve this problem, this paper adopts the methods of establishing the loss model of GaN device, putting forward the guiding principle of reducing the loss theoretically and verifying the experiment.The main achievements of this paper include: Firstly, through analyzing the loss mechanism of GaN devices, it is found that the factors affecting the loss of GaN devices include switching frequency, current waveform, temperature, etc. Secondly, the loss model of GaN device is established, which can quantitatively analyze the loss of GaN device. Then, the guiding principles of reducing the loss are put forward theoretically, including optimizing the current path, choosing the appropriate switching frequency, adopting the correct driving technology, and carrying out the effective temperature management and thermal design. Finally, the effectiveness and feasibility of these strategies are verified by experiments.