Copper‐kryptofix‐21‐Fe₃O₄/MCM‐41: A powerfully recoverable nanocatalyst for clean regioselective 1,2,3‐triazole synthesis‐click reactio n

Abstract

A novel porous and magnetic nanoparticle, composed of Fe3O4/MCM‐41 functionalized with a kryptofix‐21 crown ether, has been successfully synthesized. This was achieved through the treatment of 3‐chloropropyl functionalized Fe3O4/MCM‐41 with the crown ether, followed by the grafting of Cu (II) onto the material, resulting in the formation of Fe3O4/MCM‐41/kryptofix‐21/Cu. The material's 2D‐hexagonally ordered mesophases were analyzed using small‐angle‐PXRD and TEM‐imaging. The Cu (II)‐anchored porous material, Fe3O4/MCM‐41/kryptofix‐21/Cu, exhibited remarkable catalytic activity in the Click reaction between azides and phenylacetylene, conducted in ethylene glycol/water at a temperature of 70 °C. This reaction led to the synthesis of a diverse range of 1,4‐disubstituted 1,2,3‐triazoles. The catalyst demonstrated excellent recyclability, maintaining its catalytic activity for up to eight cycles without any significant loss. Furthermore, no significant leaching of Cu was observed, highlighting the potential of this magnetically innovative nanoporous catalyst in the regioselective formation of 1,4‐disubstituted 1,2,3‐triazolic compounds.