Copper, iron, and selenium dietary deficiencies negatively impact skeletal integrity: A review

Medeiros, Denis M.

doi:10.1177/1535370216648805

Cited by 57 publications

(54 citation statements)

References 50 publications

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“…In modern populations, Cu intake is generally sufficient; in fact, it usually exceeds what is required [46,52]. Dietary Cu absorption mainly occurs in the small intestine, and the liver plays a large role in its regulation through excretion via bile into the gastrointestinal tract in a form that prevents reabsorption [46,49,53,54].…”

Section: A Necessary Elementmentioning

confidence: 99%

“…Unusually low concentrations of Cu have been associated with several pathological conditions, although it is often unclear precisely how deficiencies are related to pathological processes [46,49,51,55]. From the perspective of the skeleton, Cu deficiency has been linked to osteoporosis, decreased bone strength, and femoral head necrosis [46,48,52,55]. Other pathological conditions are associated with high Cu levels [46,47,49,56].…”

Section: A Necessary Elementmentioning

confidence: 99%

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Copper exposure in medieval and post-medieval Denmark and northern Germany: its relationship to residence location and social position

et al. 2020

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For medieval and post-medieval Denmark and northern Germany, trace elements can potentially contribute to our understanding of diet, migration, social status, exposure to urban settings, and disease treatment. Copper, of particular interest as a marker of access to everyday metal items, can be used to clarify socioeconomic distinctions between and within communities. Postmortem alteration of bone (diagenesis), however, must be ruled out before the elements can be used to characterize life in the past. Femoral cortical bone samples of ca. 40 mg were thoroughly decontaminated, and the concentrations of Al, Ca, Mn, Fe, Cu, As, Sr, Ba, and Pb were measured using inductively coupled plasma mass spectrometry. The concentrations of these elements were quantified in bone samples from 553 skeletons from 9 rural and urban cemeteries, and 34 soil samples obtained near three burials. Copper, the primary element of interest in this work, is generally absent from the femoral cortical bone of rural people, although it occurs in high concentrations in the skeletons of the inhabitants of towns. The Cu in medieval to post-medieval bones likely originated from everyday objects, notably kitchen utensils. A rural to urban distinction in Cu concentrations, found repeatedly at two sites, likely resulted from differential access to much-desired, although still utilitarian, household items. An uneven distribution of metal objects used in domestic contexts, demonstrated through bone chemistry, was greater between rural and urban communities than it was within urban centres, at least among the socioeconomic positions sampled in this study.

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Section: A Necessary Elementmentioning

confidence: 99%

Section: A Necessary Elementmentioning

confidence: 99%

Copper exposure in medieval and post-medieval Denmark and northern Germany: its relationship to residence location and social position

et al. 2020

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“…Iron deficiency in humans has been associated with heart failure (Avni et al, 2012;Cohen-Solal et al, 2014); gastric ulceration and anemia induced by Helicobacter pylori (Beckett et al, 2016); negative impacts on skeletal integrity (Medeiros, 2016); and cognitive disorders (Ünüsan, 2013). Iron deficiency in infancy leads to long-term deficits in executive function and recognition memory (Lukowski et al, 2013).…”

Section: Importance Of Iron For Human Food and Healthmentioning

confidence: 99%

Climate engineering by mimicking natural dust climate control: the iron salt aerosol method

et al. 2017

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Abstract. Power stations, ships and air traffic are among the most potent greenhouse gas emitters and are primarily responsible for global warming. Iron salt aerosols (ISAs), composed partly of iron and chloride, exert a cooling effect on climate in several ways. This article aims firstly to examine all direct and indirect natural climate cooling mechanisms driven by ISA tropospheric aerosol particles, showing their cooperation and interaction within the different environmental compartments. Secondly, it looks at a proposal to enhance the cooling effects of ISA in order to reach the optimistic target of the Paris climate agreement to limit the global temperature increase between 1.5 and 2 • C.Mineral dust played an important role during the glacial periods; by using mineral dust as a natural analogue tool and by mimicking the same method used in nature, the proposed ISA method might be able to reduce and stop climate warming. The first estimations made in this article show that by doubling the current natural iron emissions by ISA into the troposphere, i.e., by about 0.3 Tg Fe yr −1 , artificial ISA would enable the prevention or even reversal of global warming. The ISA method proposed integrates technical and economically feasible tools.

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“…All of them are elastin‐ and collagen‐containing tissues. Brittle bones, forms of osteogenesis imperfecta, and osteoporosis are reported in children …”

Section: Manifestations Of Copper Deficiencymentioning

confidence: 99%

Copper Deficiency: Causes, Manifestations, and Treatment

et al. 2019

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Background: The metabolism of the essential trace element copper remains incompletely understood and, until recently, nearly ignored in acute medicine. Menkes disease was for long the only known copper deficiency condition, but several case reports and investigations conducted over the last 2 decades have shown that deficiency is more frequent than previously suspected, with devastating individual consequences and potential public health consequences. The copper needs in healthy individuals are 0.9 mg/d, which translates to 0.3 mg/d intravenously in parenteral nutrition; the present review aims at gathering actual knowledge. Method and results: A review of literature was conducted in PubMed and Cochrane systematic reviews to identify the most recent information about copper deficiency and generate a narrative review. Copper deficiency has hereditary and acquired origins, the latter being the most frequent. Clinical manifestations are nonspecific but affect all organs and systems, particularly the hematologic (anemia) and the neurologic (myeloneuropathy) systems. Deficiency also affects the cardiovascular, cutaneous, and immune systems. Severe copper deficiency due to reduced absorption after bariatric bypass surgery has become frequent. Conclusion: Deficiency is more frequent than previously recognized, probably because of changing nutrition patterns but also because of some treatments that have become very common such as bypass bariatric surgery and, in acute medicine, prolonged continuous renal replacement therapy. The patients may present with severe hematologic and neurologic complications that go untreated because copper deficiency was not considered in the differential diagnosis: These complications often need active intravenous repletion with doses 4-8 times the usual nutrition recommendations. (Nutr Clin Pract. 2019;34:504-513)

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Copper, iron, and selenium dietary deficiencies negatively impact skeletal integrity: A review

Cited by 57 publications

References 50 publications

Copper exposure in medieval and post-medieval Denmark and northern Germany: its relationship to residence location and social position

Copper exposure in medieval and post-medieval Denmark and northern Germany: its relationship to residence location and social position

Climate engineering by mimicking natural dust climate control: the iron salt aerosol method

Copper Deficiency: Causes, Manifestations, and Treatment

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